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Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 [ Mus musculus (house mouse) ]

Gene ID: 20588, updated on 5-Jan-2023

Summary

Official Symbol
Smarcc1provided by MGI
Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1provided by MGI
Primary source
MGI:MGI:1203524
See related
Ensembl:ENSMUSG00000032481 AllianceGenome:MGI:1203524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsc8; SRG3; msp3; BAF155
Summary
Enables chromatin binding activity. Acts upstream of or within several processes, including insulin receptor signaling pathway; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of transcription by RNA polymerase II. Located in XY body and nucleus. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human SMARCC1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 32.9), limb E14.5 (RPKM 21.9) and 28 other tissues See more
Orthologs
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Genomic context

See Smarcc1 in Genome Data Viewer
Location:
9; 9 F2
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109961092..110069246)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110132024..110240178)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 30 Neighboring gene predicted gene 10615 Neighboring gene predicted gene, 23377 Neighboring gene 4.5s RNA, pseudogene 2 Neighboring gene chondroitin sulfate proteoglycan 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within chromosome organization TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleosome disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of myoblast differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of G0 to G1 transition NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of mitotic metaphase/anaphase transition NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of nucleotide-excision repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of GBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of RSC-type complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
 
part_of SWI/SNF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of SWI/SNF complex TAS
Traceable Author Statement
more info
PubMed 
part_of SWI/SNF superfamily-type complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in XY body IDA
Inferred from Direct Assay
more info
PubMed 
part_of brahma complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in chromatin NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of nBAF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nBAF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of nBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of npBAF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of npBAF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of npBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear matrix NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
SWI/SNF complex subunit SMARCC1
Names
BRG1-associated factor 155
SWI/SNF complex 155 kDa subunit
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1
SWI3-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413569.1NP_001400498.1  SWI/SNF complex subunit SMARCC1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159372
  2. NM_001413570.1NP_001400499.1  SWI/SNF complex subunit SMARCC1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159372
  3. NM_001413571.1NP_001400500.1  SWI/SNF complex subunit SMARCC1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159372
  4. NM_001413572.1NP_001400501.1  SWI/SNF complex subunit SMARCC1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC159372
  5. NM_009211.3NP_033237.2  SWI/SNF complex subunit SMARCC1

    See identical proteins and their annotated locations for NP_033237.2

    Status: VALIDATED

    Source sequence(s)
    AC159372
    Consensus CDS
    CCDS23561.1
    UniProtKB/Swiss-Prot
    P97496, Q7TT29
    UniProtKB/TrEMBL
    Q3UPK0
    Related
    ENSMUSP00000086094.6, ENSMUST00000088716.12
    Conserved Domains (5) summary
    COG5259
    Location:443709
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam04433
    Location:451536
    SWIRM; SWIRM domain
    pfam16495
    Location:882953
    SWIRM-assoc_1; SWIRM-associated region 1
    pfam16496
    Location:31444
    SWIRM-assoc_2; SWIRM-associated domain at the N-terminal
    pfam16498
    Location:705769
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    109961092..110069246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)