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ZSCAN18 zinc finger and SCAN domain containing 18 [ Homo sapiens (human) ]

Gene ID: 65982, updated on 4-Jul-2021

Summary

Official Symbol
ZSCAN18provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 18provided by HGNC
Primary source
HGNC:HGNC:21037
See related
Ensembl:ENSG00000121413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF447
Expression
Ubiquitous expression in brain (RPKM 14.7), endometrium (RPKM 11.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZSCAN18 in Genome Data Viewer
Location:
19q13.43
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (58083834..58118433, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58595209..58629793, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 135 Neighboring gene RNA, 7SL, cytoplasmic 526, pseudogene Neighboring gene zinc finger protein 329 Neighboring gene zinc finger protein 274

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2427, MGC4074, MGC8682, FLJ12895, FLJ38919, FLJ44152, DKFZp586B1122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger and SCAN domain-containing protein 18
Names
zinc finger protein 447

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145542.1NP_001139014.1  zinc finger and SCAN domain-containing protein 18 isoform 1

    See identical proteins and their annotated locations for NP_001139014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AK294376, BC006205, DC354023
    Consensus CDS
    CCDS46214.1
    UniProtKB/Swiss-Prot
    Q8TBC5
    Related
    ENSP00000470123.1, ENST00000600404.1
    Conserved Domains (3) summary
    smart00349
    Location:284321
    KRAB; krueppel associated box
    sd00017
    Location:471491
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:102189
    SCAN; SCAN domain
  2. NM_001145543.2NP_001139015.1  zinc finger and SCAN domain-containing protein 18 isoform 3

    See identical proteins and their annotated locations for NP_001139015.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different segment for its 5' UTR and lacks a coding region segment, which results in the use of a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same protein (isoform 3), which is shorter when it is compared to isoform 1.
    Source sequence(s)
    AY280799, BC006205
    Consensus CDS
    CCDS12971.1
    UniProtKB/Swiss-Prot
    Q8TBC5
    UniProtKB/TrEMBL
    A0A024R4T0
    Related
    ENSP00000468934.1, ENST00000601144.6
    Conserved Domains (3) summary
    smart00349
    Location:228265
    KRAB; krueppel associated box
    sd00017
    Location:415435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:46133
    SCAN; SCAN domain
  3. NM_001145544.2NP_001139016.1  zinc finger and SCAN domain-containing protein 18 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR and lacks a coding region segment, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    BC006205, BG036776, DA611622
    Consensus CDS
    CCDS46215.1
    UniProtKB/Swiss-Prot
    Q8TBC5
    Related
    ENSP00000392653.1, ENST00000421612.6
    Conserved Domains (2) summary
    smart00349
    Location:93130
    KRAB; krueppel associated box
    sd00017
    Location:279299
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_023926.5NP_076415.3  zinc finger and SCAN domain-containing protein 18 isoform 3

    See identical proteins and their annotated locations for NP_076415.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different segment for its 5' UTR and lacks a coding region segment, which results in the use of a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same protein (isoform 3), which is shorter when it is compared to isoform 1.
    Source sequence(s)
    BC006205, BC022846, BG036776
    Consensus CDS
    CCDS12971.1
    UniProtKB/Swiss-Prot
    Q8TBC5
    UniProtKB/TrEMBL
    A0A024R4T0
    Related
    ENSP00000240727.5, ENST00000240727.10
    Conserved Domains (3) summary
    smart00349
    Location:228265
    KRAB; krueppel associated box
    sd00017
    Location:415435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:46133
    SCAN; SCAN domain

RNA

  1. NR_027135.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents transcription from an upstream promoter and shares the first exon with variant 1. This two-exon transcript includes a different terminal exon but the predicted protein is not represented because there is uncertainty about the protein-coding capacity of the transcript.
    Source sequence(s)
    AC008751
    Related
    ENST00000595944.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    58083834..58118433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723335.2XP_006723398.1  zinc finger and SCAN domain-containing protein 18 isoform X2

    See identical proteins and their annotated locations for XP_006723398.1

    UniProtKB/Swiss-Prot
    Q8TBC5
    UniProtKB/TrEMBL
    A0A024R4T0
    Conserved Domains (3) summary
    smart00349
    Location:228265
    KRAB; krueppel associated box
    sd00017
    Location:415435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:46133
    SCAN; SCAN domain
  2. XM_011527239.3XP_011525541.1  zinc finger and SCAN domain-containing protein 18 isoform X2

    See identical proteins and their annotated locations for XP_011525541.1

    UniProtKB/Swiss-Prot
    Q8TBC5
    UniProtKB/TrEMBL
    A0A024R4T0
    Conserved Domains (3) summary
    smart00349
    Location:228265
    KRAB; krueppel associated box
    sd00017
    Location:415435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:46133
    SCAN; SCAN domain
  3. XM_011527238.1XP_011525540.1  zinc finger and SCAN domain-containing protein 18 isoform X2

    See identical proteins and their annotated locations for XP_011525540.1

    UniProtKB/Swiss-Prot
    Q8TBC5
    UniProtKB/TrEMBL
    A0A024R4T0
    Conserved Domains (3) summary
    smart00349
    Location:228265
    KRAB; krueppel associated box
    sd00017
    Location:415435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:46133
    SCAN; SCAN domain
  4. XM_005259174.5XP_005259231.1  zinc finger and SCAN domain-containing protein 18 isoform X2

    See identical proteins and their annotated locations for XP_005259231.1

    UniProtKB/Swiss-Prot
    Q8TBC5
    UniProtKB/TrEMBL
    A0A024R4T0
    Conserved Domains (3) summary
    smart00349
    Location:228265
    KRAB; krueppel associated box
    sd00017
    Location:415435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:46133
    SCAN; SCAN domain
  5. XM_017027170.2XP_016882659.1  zinc finger and SCAN domain-containing protein 18 isoform X3

    UniProtKB/Swiss-Prot
    Q8TBC5
  6. XM_017027169.2XP_016882658.1  zinc finger and SCAN domain-containing protein 18 isoform X3

    UniProtKB/Swiss-Prot
    Q8TBC5
    Related
    ENSP00000412253.2, ENST00000433686.6
  7. XM_017027171.2XP_016882660.1  zinc finger and SCAN domain-containing protein 18 isoform X3

    UniProtKB/Swiss-Prot
    Q8TBC5
  8. XM_011527237.2XP_011525539.1  zinc finger and SCAN domain-containing protein 18 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:284321
    KRAB; krueppel associated box
    sd00017
    Location:470490
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:102189
    SCAN; SCAN domain
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