Format

Send to:

Choose Destination

SLCO2A1 solute carrier organic anion transporter family member 2A1 [ Homo sapiens (human) ]

Gene ID: 6578, updated on 6-Sep-2017
Official Symbol
SLCO2A1provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 2A1provided by HGNC
Primary source
HGNC:HGNC:10955
See related
Ensembl:ENSG00000174640 MIM:601460; Vega:OTTHUMG00000159745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGT; MATR1; PHOAR2; OATP2A1; SLC21A2
Summary
This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]
Orthologs
Location:
3q22.1-q22.2
Exon count:
16
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (133932696..134030076, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (133651540..133748920, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RAB6B, member RAS oncogene family Neighboring gene chromosome 3 open reading frame 36 Neighboring gene uncharacterized LOC105374117 Neighboring gene long intergenic non-protein coding RNA 2000

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of solute carrier organic anion transporter family, member 2A1 (SLCO2A1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid transporter activity TAS
Traceable Author Statement
more info
PubMed 
prostaglandin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
prostaglandin transmembrane transporter activity TAS
Traceable Author Statement
more info
 
sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
lipid transport TAS
Traceable Author Statement
more info
PubMed 
prostaglandin transport IEA
Inferred from Electronic Annotation
more info
 
sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
sodium-independent organic anion transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
solute carrier organic anion transporter family member 2A1
Names
matrin F/G 1
solute carrier family 21 (prostaglandin transporter), member 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031964.2 RefSeqGene

    Range
    27109..124489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005630.2NP_005621.2  solute carrier organic anion transporter family member 2A1

    See identical proteins and their annotated locations for NP_005621.2

    Status: REVIEWED

    Source sequence(s)
    BC041140, BC051347, BU783445, DA592947, U70867
    Consensus CDS
    CCDS3084.1
    UniProtKB/Swiss-Prot
    Q92959
    Related
    ENSP00000311291.4, OTTHUMP00000216361, ENST00000310926.8, OTTHUMT00000357131
    Conserved Domains (1) summary
    TIGR00805
    Location:1630
    oat; sodium-independent organic anion transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

    Range
    133932696..134030076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007075.1XP_016862564.1  solute carrier organic anion transporter family member 2A1 isoform X1

  2. XM_017007077.1XP_016862566.1  solute carrier organic anion transporter family member 2A1 isoform X3

  3. XM_017007076.1XP_016862565.1  solute carrier organic anion transporter family member 2A1 isoform X2

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    133615353..133712732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center