Slco2a1 solute carrier organic anion transporter family, member 2a1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slco2a1provided by MGI
Official Full Name: solute carrier organic anion transporter family, member 2a1provided by MGI
Primary source: MGI:MGI:1346021
See related: Ensembl:ENSMUSG00000032548 AllianceGenome:MGI:1346021
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pgt; PHOAR2; OATP2A1; Slc21a2; 2310021C19Rik
Summary: Enables prostaglandin transmembrane transporter activity. Acts upstream of or within prostaglandin transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including ganglia; nose; renal cortex; respiratory system; and skin. Human ortholog(s) of this gene implicated in primary hypertrophic osteoarthropathy. Orthologous to human SLCO2A1 (solute carrier organic anion transporter family member 2A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 114.3), spleen adult (RPKM 22.6) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 54.72 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (102885686..102973201)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (103007061..103096002)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1.
Title: Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1.
depression disorder (DD) was the adverse factors for the overall occurrence risk of hepatocellular carcinoma (HCC). Mechanistically, be the downregulation of Oatp2a1 and Oatp2b1 in liver tissue induced by DD might be involved
Title: Risk of Developing Hepatocellular Carcinoma following Depressive Disorder Based on the Expression Level of Oatp2a1 and Oatp2b1.
Our results indicate that OATP2A1 influences the local disposition of PGE2 in the brain during the febrile response
Title: Prostaglandin Transporter OATP2A1/SLCO2A1 Is Essential for Body Temperature Regulation during Fever.
studies indicate that OATP2A1 is likely to promote tumorogenesis by PGE2 uptake into the endothelial cells, suggesting that blockade of OATP2A1 is an additional pharmacologic strategy to improve colon cancer outcomes.
Title: A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer.
SLCO2A1 is an essential core component of the ATP-conductive Maxi-Cl channel.
Title: The organic anion transporter SLCO2A1 constitutes the core component of the Maxi-Cl channel.
Data suggest that prostaglandin E3 (PGE3) metabolism is downregulated in prostaglandin transporter Slco2a1(-/-) knockout mice.
Title: Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3.
Slco2a1 contributes to PGE2 secretion by macrophages via exocytosis.
Title: OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion.
Pulmonary Prostaglandin E2 disposition is largely regulated by SLCO2A1, demonstrating that SLCO2A1 plays a critical role in protecting the lung from Bleomycin-induced fibrosis.
Title: Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis.
Prostaglandin transporter plays a critical role in closure of the ductus arteriosus after birth by ensuring a reduction in local and/or circulating PGE(2) concentrations.
Title: Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice.
Renal collecting duct prostaglandin transporter transcription varied with dietary salt intake.
Title: Dietary salt induces transcription of the prostaglandin transporter gene in renal collecting ducts.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

General gene information

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Markers

Slco2a1 (e-PCR), detects polymorphism
- UniSTS:547141

D9Mgc15 (e-PCR), detects polymorphism
- UniSTS:142754

04.MMHAP88FRB7.seq (e-PCR)
- UniSTS:122790

NoName (e-PCR)
- UniSTS:236237

Homology

Homologs of the Slco2a1 gene: The Slco2a1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 348 organisms have orthologs with human gene Slco2a1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables prostaglandin transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables prostaglandin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within prostaglandin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: solute carrier organic anion transporter family member 2A1

Names: solute carrier family 21 (prostaglandin transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033314.4 → NP_201571.2 solute carrier organic anion transporter family member 2A1

See identical proteins and their annotated locations for NP_201571.2

Status: VALIDATED

Source sequence(s)

AC156633, AK087350, AK166724

Consensus CDS

CCDS23448.1

UniProtKB/Swiss-Prot

Q9EPT5

UniProtKB/TrEMBL

Q3TED0

Related

ENSMUSP00000035148.7, ENSMUST00000035148.13

Conserved Domains (3) summary

cd06174
Location:166 → 425

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:441 → 494

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

TIGR00805
Location:1 → 629

oat; sodium-independent organic anion transporter