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SLC7A4 solute carrier family 7 member 4 [ Homo sapiens (human) ]

Gene ID: 6545, updated on 5-Aug-2022

Summary

Official Symbol
SLC7A4provided by HGNC
Official Full Name
solute carrier family 7 member 4provided by HGNC
Primary source
HGNC:HGNC:11062
See related
Ensembl:ENSG00000099960 MIM:603752; AllianceGenome:HGNC:11062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VH; CAT4; CAT-4; HCAT3
Summary
Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transport. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 11.6), esophagus (RPKM 3.0) and 12 other tissues See more
Orthologs
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Genomic context

See SLC7A4 in Genome Data Viewer
Location:
22q11.21
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (21028718..21032561, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (21437477..21441320, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21383007..21386850, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene THAP domain containing 7 Neighboring gene THAP7 antisense RNA 1 Neighboring gene tubulin alpha 3f pseudogene Neighboring gene purinergic receptor P2X 6 Neighboring gene microRNA 649 Neighboring gene purinergic receptor P2X 6 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The CDR1, FR2, and CDR3 regions of the VH3 family gene significantly contribute to its binding to HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129976, MGC129977

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables basic amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in basic amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cationic amino acid transporter 4
Names
Ig heavy chain variable region
VH 3 family
solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
solute carrier family 7 (orphan transporter), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004173.3NP_004164.2  cationic amino acid transporter 4

    See identical proteins and their annotated locations for NP_004164.2

    Status: VALIDATED

    Source sequence(s)
    AC002472, BC008814, BC062565
    Consensus CDS
    CCDS33608.1
    UniProtKB/Swiss-Prot
    O43246, Q96H88
    Related
    ENSP00000372390.2, ENST00000382932.3
    Conserved Domains (2) summary
    TIGR00906
    Location:26592
    2A0303; cationic amino acid transport permease
    pfam13906
    Location:540590
    AA_permease_C; C-terminus of AA_permease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    21028718..21032561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441472.1XP_047297428.1  cationic amino acid transporter 4 isoform X1

    UniProtKB/Swiss-Prot
    Q96H88

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    21437477..21441320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)