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SLC7A4 solute carrier family 7 member 4 [ Homo sapiens (human) ]

Gene ID: 6545, updated on 21-Dec-2019

Summary

Official Symbol
SLC7A4provided by HGNC
Official Full Name
solute carrier family 7 member 4provided by HGNC
Primary source
HGNC:HGNC:11062
See related
Ensembl:ENSG00000099960 MIM:603752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VH; CAT4; CAT-4; HCAT3
Expression
Biased expression in testis (RPKM 11.6), esophagus (RPKM 3.0) and 12 other tissues See more
Orthologs

Genomic context

See SLC7A4 in Genome Data Viewer
Location:
22q11.21
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (21028718..21032561, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21382995..21387163, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene THAP domain containing 7 Neighboring gene THAP7 antisense RNA 1 Neighboring gene tubulin alpha 3f pseudogene Neighboring gene purinergic receptor P2X 6 Neighboring gene microRNA 649 Neighboring gene purinergic receptor P2X 6 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The CDR1, FR2, and CDR3 regions of the VH3 family gene significantly contribute to its binding to HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Clone Names

  • MGC129976, MGC129977

Gene Ontology Provided by GOA

Function Evidence Code Pubs
basic amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
basic amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cationic amino acid transporter 4
Names
Ig heavy chain variable region
VH 3 family
solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
solute carrier family 7 (orphan transporter), member 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004173.3NP_004164.2  cationic amino acid transporter 4

    See identical proteins and their annotated locations for NP_004164.2

    Status: VALIDATED

    Source sequence(s)
    AC002472, BC008814, BC062565
    Consensus CDS
    CCDS33608.1
    UniProtKB/Swiss-Prot
    O43246
    Related
    ENSP00000372390.2, ENST00000382932.3
    Conserved Domains (2) summary
    TIGR00906
    Location:26592
    2A0303; cationic amino acid transport permease
    pfam13906
    Location:540590
    AA_permease_C; C-terminus of AA_permease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    21028718..21032561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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