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SLC7A1 solute carrier family 7 member 1 [ Homo sapiens (human) ]

Gene ID: 6541, updated on 8-Aug-2021

Summary

Official Symbol
SLC7A1provided by HGNC
Official Full Name
solute carrier family 7 member 1provided by HGNC
Primary source
HGNC:HGNC:11057
See related
Ensembl:ENSG00000139514 MIM:104615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERR; ATRC1; CAT-1; HCAT1; REC1L
Expression
Ubiquitous expression in esophagus (RPKM 22.4), brain (RPKM 11.3) and 24 other tissues See more
Orthologs
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Genomic context

See SLC7A1 in Genome Data Viewer
Location:
13q12.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (29509410..29595688, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (30083551..30169825, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene microtubule associated scaffold protein 2 Neighboring gene Sharpr-MPRA regulatory region 1517 Neighboring gene MTUS2 antisense RNA 1 Neighboring gene uncharacterized LOC102723345 Neighboring gene uncharacterized LOC105370139

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC7A1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in L-amino acid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-arginine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in L-arginine import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in L-histidine import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-lysine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-ornithine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in amino acid import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in amino acid transport TAS
Traceable Author Statement
more info
 
involved_in arginine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in basic amino acid transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lysine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ornithine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
high affinity cationic amino acid transporter 1
Names
CAT1
amino acid transporter, cationic 1
ecotropic retroviral leukemia receptor homolog
ecotropic retroviral receptor
ecotropic retrovirus receptor homolog
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
system Y+ basic amino acid transporter

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003045.5NP_003036.1  high affinity cationic amino acid transporter 1

    See identical proteins and their annotated locations for NP_003036.1

    Status: VALIDATED

    Source sequence(s)
    AL596114
    Consensus CDS
    CCDS9333.1
    UniProtKB/Swiss-Prot
    P30825
    UniProtKB/TrEMBL
    A0A024RDQ9
    Related
    ENSP00000370128.5, ENST00000380752.10
    Conserved Domains (1) summary
    TIGR00906
    Location:4610
    2A0303; cationic amino acid transport permease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    29509410..29595688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020713.2XP_016876202.1  high affinity cationic amino acid transporter 1 isoform X1

  2. XM_005266507.3XP_005266564.1  high affinity cationic amino acid transporter 1 isoform X2

    See identical proteins and their annotated locations for XP_005266564.1

    UniProtKB/Swiss-Prot
    P30825
    UniProtKB/TrEMBL
    A0A024RDQ9
    Conserved Domains (1) summary
    TIGR00906
    Location:4610
    2A0303; cationic amino acid transport permease
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