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Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 [ Mus musculus (house mouse) ]

Gene ID: 11987, updated on 13-Apr-2024

Summary

Official Symbol
Slc7a1provided by MGI
Official Full Name
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1provided by MGI
Primary source
MGI:MGI:88117
See related
Ensembl:ENSMUSG00000041313 AllianceGenome:MGI:88117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERR; Cat1; EcoR; Atrc1; CAT-1; Rec-1; Rev-1; Atrc-1; mCAT-1; 4831426K01Rik
Summary
Enables L-arginine transmembrane transporter activity. Acts upstream of or within L-arginine transmembrane transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; cranium; genitourinary system; and immune system. Orthologous to human SLC7A1 (solute carrier family 7 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 11.4), genital fat pad adult (RPKM 10.4) and 27 other tissues See more
Orthologs
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Genomic context

See Slc7a1 in Genome Data Viewer
Location:
5 G3; 5 88.48 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (148264220..148336714, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (148327410..148399904, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene microtubule associated tumor suppressor candidate 2 Neighboring gene STARR-seq mESC enhancer starr_14894 Neighboring gene predicted gene, 46928 Neighboring gene STARR-seq mESC enhancer starr_14896 Neighboring gene fused in sarcoma pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E675 Neighboring gene STARR-seq mESC enhancer starr_14901 Neighboring gene STARR-positive B cell enhancer mm9_chr5:149263482-149263782 Neighboring gene STARR-seq mESC enhancer starr_14907 Neighboring gene STARR-seq mESC enhancer starr_14908 Neighboring gene ubiquitin-like 3 Neighboring gene predicted gene, 35735

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in L-amino acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in L-arginine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-arginine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within L-arginine transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-arginine transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-arginine transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in L-histidine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-ornithine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-ornithine transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amino acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lysine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in ornithine transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IC
Inferred by Curator
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
high affinity cationic amino acid transporter 1
Names
cationic amino acid transporter 1
ecotropic retroviral leukemia receptor
ecotropic retrovirus receptor
solute carrier family 7 member 1
system Y+ basic amino acid transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301424.2NP_001288353.1  high affinity cationic amino acid transporter 1

    See identical proteins and their annotated locations for NP_001288353.1

    Status: VALIDATED

    Source sequence(s)
    AC109498
    Consensus CDS
    CCDS19882.1
    UniProtKB/Swiss-Prot
    P30824, Q09143
    UniProtKB/TrEMBL
    Q3UGD6, Q3UTL4
    Related
    ENSMUSP00000117781.2, ENSMUST00000138257.8
    Conserved Domains (1) summary
    TIGR00906
    Location:4603
    2A0303; cationic amino acid transport permease
  2. NM_001429137.1NP_001416066.1  high affinity cationic amino acid transporter 1

    Status: VALIDATED

    Source sequence(s)
    AC109498
  3. NM_001429138.1NP_001416067.1  high affinity cationic amino acid transporter 1

    Status: VALIDATED

    Source sequence(s)
    AC109498
  4. NM_007513.5NP_031539.3  high affinity cationic amino acid transporter 1

    See identical proteins and their annotated locations for NP_031539.3

    Status: VALIDATED

    Source sequence(s)
    AC109498
    Consensus CDS
    CCDS19882.1
    UniProtKB/Swiss-Prot
    P30824, Q09143
    UniProtKB/TrEMBL
    Q3UGD6, Q3UTL4
    Related
    ENSMUSP00000046714.9, ENSMUST00000048116.15
    Conserved Domains (1) summary
    TIGR00906
    Location:4603
    2A0303; cationic amino acid transport permease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    148264220..148336714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504796.3XP_006504859.1  high affinity cationic amino acid transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P30824, Q09143
    UniProtKB/TrEMBL
    Q3UGD6, Q3UTL4
    Conserved Domains (1) summary
    TIGR00906
    Location:4603
    2A0303; cationic amino acid transport permease