Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc7a1provided by MGI
Official Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 1provided by MGI
Primary source: MGI:MGI:88117
See related: Ensembl:ENSMUSG00000041313 AllianceGenome:MGI:88117
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cat1; EcoR; Atrc1; Rec-1; Rev-1; Atrc-1; mCAT-1; 4831426K01Rik
Summary: Enables L-arginine transmembrane transporter activity. Acts upstream of or within L-arginine transmembrane transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; cranium; genitourinary system; and immune system. Orthologous to human SLC7A1 (solute carrier family 7 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 11.4), genital fat pad adult (RPKM 10.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G3; 5 88.48 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (148264220..148336714, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (148327410..148399904, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis.
Title: Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis.
Endothelial-specific overexpression of cationic amino acid transporter-1 prevents loss of kidney function in heart failure.
Title: Endothelial-specific overexpression of cationic amino acid transporter-1 prevents loss of kidney function in heart failure.
A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet.
Title: MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
Endothelial CAT-1 overexpression can counter the ability of oxidative stress.
Title: Endothelial cationic amino acid transporter-1 overexpression blunts the effects of oxidative stress on pressor responses to behavioural stress in mice.
L-argine transporters CAT-1 and CAT-2A expression and function are significantly increased in Duchenne muscular dystrophy mice.
Title: Nitric oxide signalling pathway in Duchenne muscular dystrophy mice: up-regulation of L-arginine transporters.
findings suggest a novel role for GRB2 in ecotropic MLV entry and infection by facilitating mCAT-1 trafficking
Title: GRB2 interaction with the ecotropic murine leukemia virus receptor, mCAT-1, controls virus entry and is stimulated by virus binding.
analysis of how a bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha)
Title: A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha).
Ecotropic mouse gammaretroviruses entry and virus-induced syncytium formation using the CAT-1 receptor are mediated by a small number of critical amino acid residues in receptor and virus Env.
Title: Role of receptor polymorphism and glycosylation in syncytium induction and host range variation of ecotropic mouse gammaretroviruses.
Ecotropic MuLV and its env protein downregulate the MuLV receptor (CAT1) via interaction of CAT1 with clathrin adaptor protein complexes.
Title: Ecotropic murine leukemia virus envelope protein affects interaction of cationic amino acid transporter 1 with clathrin adaptor protein complexes, leading to receptor downregulation.
In a neuronal cell model, y+,L and y+ transport systems are the predominant form of arginine uptake mechanisms and the transport of arginine is altered by membrane potential and redox factors.
Title: Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M26687 (e-PCR)
- UniSTS:185650

Slc7a1 (e-PCR), detects polymorphism
- UniSTS:547134

Slc7a1 (e-PCR), detects polymorphism
- UniSTS:527021

Cyba (e-PCR), detects polymorphism
- UniSTS:548034

AI447493 (e-PCR)
- UniSTS:164307

Homology

Homologs of the Slc7a1 gene: The Slc7a1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 360 organisms have orthologs with human gene Slc7a1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-arginine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-histidine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-lysine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables L-lysine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-lysine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-ornithine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables L-ornithine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables basic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables virus receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in L-arginine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in L-arginine import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within L-arginine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-arginine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-arginine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-histidine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-ornithine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in L-ornithine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in lysine transport	ISO Inferred from Sequence Orthology more info
involved_in ornithine transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IC Inferred by Curator more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: high affinity cationic amino acid transporter 1

Names: CAT-1; ERR; cationic amino acid transporter 1; ecotropic retroviral leukemia receptor; ecotropic retrovirus receptor; solute carrier family 7 member 1; system Y+ basic amino acid transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301424.1 → NP_001288353.1 high affinity cationic amino acid transporter 1

See identical proteins and their annotated locations for NP_001288353.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK163202, BC051230, BC068234, CD559786

Consensus CDS

CCDS19882.1

UniProtKB/Swiss-Prot

P30824, Q09143

UniProtKB/TrEMBL

A0A8C6N189, Q3TQZ8, Q3UGD6

Related

ENSMUSP00000117781.2, ENSMUST00000138257.8

Conserved Domains (1) summary

TIGR00906
Location:4 → 603

2A0303; cationic amino acid transport permease
NM_007513.4 → NP_031539.3 high affinity cationic amino acid transporter 1

See identical proteins and their annotated locations for NP_031539.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) and variant 2 encode the same protein.

Source sequence(s)

AC109498, BC051230, CJ098794, M26687

Consensus CDS

CCDS19882.1

UniProtKB/Swiss-Prot

P30824, Q09143

UniProtKB/TrEMBL

A0A8C6N189, Q3UGD6

Related

ENSMUSP00000046714.9, ENSMUST00000048116.15

Conserved Domains (1) summary

TIGR00906
Location:4 → 603

2A0303; cationic amino acid transport permease