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ZNF649 zinc finger protein 649 [ Homo sapiens (human) ]

Gene ID: 65251, updated on 6-Sep-2022

Summary

Official Symbol
ZNF649provided by HGNC
Official Full Name
zinc finger protein 649provided by HGNC
Primary source
HGNC:HGNC:25741
See related
Ensembl:ENSG00000198093 MIM:611903; AllianceGenome:HGNC:25741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription, DNA-templated. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 9.0), thyroid (RPKM 4.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF649 in Genome Data Viewer
Location:
19q13.41
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51889235..51905017, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54976430..54992212, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52392488..52408270, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 577 Neighboring gene zinc finger protein 84 pseudogene Neighboring gene vomeronasal 1 receptor 98 pseudogene Neighboring gene ZNF649 antisense RNA 1 Neighboring gene zinc finger protein 41 pseudogene Neighboring gene zinc finger protein 613

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12644

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023074.4NP_075562.2  zinc finger protein 649

    See identical proteins and their annotated locations for NP_075562.2

    Status: VALIDATED

    Source sequence(s)
    AC011460, AK315487, AL713677, DA782250
    Consensus CDS
    CCDS12843.1
    UniProtKB/Swiss-Prot
    Q9BS31, Q9H9N2
    Related
    ENSP00000347043.2, ENST00000354957.8
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:260321
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:264284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:389413
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51889235..51905017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439238.1XP_047295194.1  zinc finger protein 649 isoform X1

  2. XM_047439239.1XP_047295195.1  zinc finger protein 649 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54976430..54992212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)