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SLC1A5 solute carrier family 1 member 5 [ Homo sapiens (human) ]

Gene ID: 6510, updated on 7-Apr-2024

Summary

Official Symbol
SLC1A5provided by HGNC
Official Full Name
solute carrier family 1 member 5provided by HGNC
Primary source
HGNC:HGNC:10943
See related
Ensembl:ENSG00000105281 MIM:109190; AllianceGenome:HGNC:10943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R16; AAAT; ATBO; M7V1; RDRC; ASCT2; M7VS1
Summary
The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]
Expression
Ubiquitous expression in fat (RPKM 39.0), prostate (RPKM 26.2) and 22 other tissues See more
Orthologs
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Genomic context

See SLC1A5 in Genome Data Viewer
Location:
19q13.32
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46774883..46788594, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49600712..49614415, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47278140..47291851, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein kinase D2 Neighboring gene uncharacterized LOC107987269 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47228602-47229146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47230777-47231320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47231865-47232408 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:47233845-47235044 Neighboring gene striatin 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10826 Neighboring gene Sharpr-MPRA regulatory region 2893 Neighboring gene fukutin related protein Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:47287225-47288424 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47288509-47289110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47289111-47289712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10831 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47291519-47292120 Neighboring gene heterogeneous nuclear ribonucleoprotein M pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14850 Neighboring gene small NF90 (ILF3) associated RNA E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC1A5 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated solute carrier family 1 (neutral amino acid transporter), member 5 (SLC1A5) protein is incorporated into HIV-1 Gag virus-like particles PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ31068

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-aspartate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-aspartate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables L-glutamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-glutamine transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
enables L-serine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ligand-gated channel activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-aspartate import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-aspartate import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in L-glutamine import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in L-serine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transport TAS
Traceable Author Statement
more info
 
involved_in erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glutamine secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in glutamine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutamine transport TAS
Traceable Author Statement
more info
PubMed 
involved_in neutral amino acid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein homotrimerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
 
involved_in transport across blood-brain barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome HDA PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neutral amino acid transporter B(0)
Names
ASC amino acid transporter-2
ATB(0)
Alanine/serine/cysteine transporter 2
RD114 virus receptor
RD114/simian type D retrovirus receptor
baboon M7 virus receptor
neutral amino acid transporter B
sodium-dependent neutral amino acid transporter type 2
solute carrier family 1 (neutral amino acid transporter), member 5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145144.2NP_001138616.1  neutral amino acid transporter B(0) isoform 2

    See identical proteins and their annotated locations for NP_001138616.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC008622, AK301661
    Consensus CDS
    CCDS46126.1
    UniProtKB/TrEMBL
    B4DE27
    Related
    ENSP00000397924.1, ENST00000412532.6
    Conserved Domains (1) summary
    pfam00375
    Location:2254
    SDF; Sodium:dicarboxylate symporter family
  2. NM_001145145.2NP_001138617.1  neutral amino acid transporter B(0) isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC008622, AK299137
    Consensus CDS
    CCDS46125.1
    UniProtKB/TrEMBL
    M0QXM4
    Related
    ENSP00000406532.1, ENST00000434726.6
    Conserved Domains (1) summary
    pfam00375
    Location:28280
    SDF; Sodium:dicarboxylate symporter family
  3. NM_005628.3NP_005619.1  neutral amino acid transporter B(0) isoform 1

    See identical proteins and their annotated locations for NP_005619.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB209738, AC008622, AK301661, U53347
    Consensus CDS
    CCDS12692.1
    UniProtKB/Swiss-Prot
    A8K9H5, B4DR77, B4DWS4, B7ZB81, D0EYG6, E9PC01, O95720, Q15758, Q96RL9, Q9BWQ3, Q9UNP2
    UniProtKB/TrEMBL
    Q71UA6
    Related
    ENSP00000444408.1, ENST00000542575.6
    Conserved Domains (1) summary
    pfam00375
    Location:106482
    SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    46774883..46788594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    49600712..49614415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)