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Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 5 [ Mus musculus (house mouse) ]

Gene ID: 20514, updated on 8-Feb-2024

Summary

Official Symbol
Slc1a5provided by MGI
Official Full Name
solute carrier family 1 (neutral amino acid transporter), member 5provided by MGI
Primary source
MGI:MGI:105305
See related
Ensembl:ENSMUSG00000001918 AllianceGenome:MGI:105305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
R16; AAAT; ATBO; M7V1; RDRC; ASCT2; M7VS1; Slc1a7
Summary
Enables L-aspartate transmembrane transporter activity and neutral amino acid transmembrane transporter activity. Involved in L-aspartate import across plasma membrane and transport across blood-brain barrier. Located in basal plasma membrane. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver; and respiratory system. Orthologous to human SLC1A5 (solute carrier family 1 member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 377.3), mammary gland adult (RPKM 328.6) and 17 other tissues See more
Orthologs
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Genomic context

See Slc1a5 in Genome Data Viewer
Location:
7 A2; 7 9.15 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16515259..16532199)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16781334..16798274)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3700 Neighboring gene CEA cell adhesion molecule 9 Neighboring gene STARR-positive B cell enhancer ABC_E4899 Neighboring gene STARR-positive B cell enhancer ABC_E6517 Neighboring gene adaptor-related protein complex 2, sigma 1 subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:17351790-17352086 Neighboring gene STARR-positive B cell enhancer ABC_E694 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:17368547-17368700 Neighboring gene fukutin related protein Neighboring gene striatin, calmodulin binding protein 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:17426612-17426765 Neighboring gene STARR-positive B cell enhancer ABC_E9686 Neighboring gene STARR-positive B cell enhancer ABC_E4900 Neighboring gene protein kinase D2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC46952

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-aspartate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-aspartate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-aspartate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables L-glutamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables L-serine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated channel activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neutral L-amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neutral amino acid transporter B(0)
Names
ASC-like Na(+)-dependent neutral amino acid transporter ASCT2
ATB(0)
insulin-activated amino acid transporter
sodium-dependent neutral amino acid transporter type 2
solute carrier family 1 member 5
solute carrier family 1, member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009201.2NP_033227.2  neutral amino acid transporter B(0)

    See identical proteins and their annotated locations for NP_033227.2

    Status: VALIDATED

    Source sequence(s)
    AK148346, AK157838
    Consensus CDS
    CCDS39785.1
    UniProtKB/TrEMBL
    Q3UFR4, Q9ESU7
    Related
    ENSMUSP00000104136.3, ENSMUST00000108496.9
    Conserved Domains (1) summary
    pfam00375
    Location:55496
    SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    16515259..16532199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539695.3XP_006539758.1  neutral amino acid transporter B(0) isoform X1

    Conserved Domains (1) summary
    pfam00375
    Location:25232
    SDF; Sodium:dicarboxylate symporter family

RNA

  1. XR_391052.3 RNA Sequence