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SLC30A5 solute carrier family 30 member 5 [ Homo sapiens (human) ]

Gene ID: 64924, updated on 23-Sep-2022

Summary

Official Symbol
SLC30A5provided by HGNC
Official Full Name
solute carrier family 30 member 5provided by HGNC
Primary source
HGNC:HGNC:19089
See related
Ensembl:ENSG00000145740 MIM:607819; AllianceGenome:HGNC:19089
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNT5; ZTL1; ZNTL1; ZnT-5
Summary
This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in thyroid (RPKM 17.6), gall bladder (RPKM 11.0) and 25 other tissues See more
Orthologs
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Genomic context

See SLC30A5 in Genome Data Viewer
Location:
5q13.1-q13.2
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (69094014..69131069)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (69916495..69953585)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (68389841..68426896)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 3C pseudogene Neighboring gene SUMO2 pseudogene 4 Neighboring gene Sharpr-MPRA regulatory region 11799 Neighboring gene small nucleolar RNA, H/ACA box 50D Neighboring gene small nucleolar RNA U13 Neighboring gene cyclin B1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5499, FLJ12496, FLJ12756

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 
enables zinc ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
acts_upstream_of_positive_effect GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cobalt ion transport IDA
Inferred from Direct Assay
more info
 
involved_in insulin processing TAS
Traceable Author Statement
more info
 
involved_in metal ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in zinc ion import into Golgi lumen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in zinc ion import into organelle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in zinc ion transmembrane transport TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within zinc ion transport IDA
Inferred from Direct Assay
more info
 
Component Evidence Code Pubs
located_in ER to Golgi transport vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi cis cisterna membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
 
located_in secretory granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
zinc transporter 5
Names
solute carrier family 30 (zinc transporter), member 5
zinc transporter ZTL1
znT-like transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030415.2 RefSeqGene

    Range
    5066..42121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001251969.2NP_001238898.1  zinc transporter 5 isoform 3

    See identical proteins and their annotated locations for NP_001238898.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region, differs in the 3' UTR and lacks a large portion of the coding region, compared to variant 1. The encoded isoform (3) is significantly shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC017441, BC144349, DB090660
    Consensus CDS
    CCDS58955.1
    UniProtKB/Swiss-Prot
    Q8TAD4
    Related
    ENSP00000421251.1, ENST00000502979.1
  2. NM_022902.5NP_075053.2  zinc transporter 5 isoform 1

    See identical proteins and their annotated locations for NP_075053.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL833716, BX537394, DB090660
    Consensus CDS
    CCDS3996.1
    UniProtKB/Swiss-Prot
    Q8TAD4, Q9H9H1
    Related
    ENSP00000379836.3, ENST00000396591.8
    Conserved Domains (2) summary
    TIGR01297
    Location:428729
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:428649
    Cation_efflux; Cation efflux family
  3. NM_024055.5NP_076960.1  zinc transporter 5 isoform 2

    See identical proteins and their annotated locations for NP_076960.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and lacks a large portion of the coding region, compared to variant 1. The encoded isoform (2) is significantly shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC017441, DB090660
    Consensus CDS
    CCDS34173.1
    UniProtKB/Swiss-Prot
    Q8TAD4
    Related
    ENSP00000370241.4, ENST00000380860.8

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    69094014..69131069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714672.5XP_006714735.1  zinc transporter 5 isoform X2

    Conserved Domains (2) summary
    COG1230
    Location:412670
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:428649
    Cation_efflux; Cation efflux family
  2. XM_005248569.4XP_005248626.1  zinc transporter 5 isoform X1

    Conserved Domains (2) summary
    TIGR01297
    Location:387688
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:387608
    Cation_efflux; Cation efflux family
  3. XM_017009749.2XP_016865238.1  zinc transporter 5 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    69916495..69953585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)