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SLC30A5 solute carrier family 30 member 5 [ Homo sapiens (human) ]

Gene ID: 64924, updated on 13-Mar-2020

Summary

Official Symbol
SLC30A5provided by HGNC
Official Full Name
solute carrier family 30 member 5provided by HGNC
Primary source
HGNC:HGNC:19089
See related
Ensembl:ENSG00000145740 MIM:607819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNT5; ZTL1; ZNTL1; ZnT-5
Summary
This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in thyroid (RPKM 17.6), gall bladder (RPKM 11.0) and 25 other tissues See more
Orthologs

Genomic context

See SLC30A5 in Genome Data Viewer
Location:
5q13.1-q13.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (69093993..69131069)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (68389776..68426899)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 3C pseudogene Neighboring gene SUMO2 pseudogene 4 Neighboring gene small nucleolar RNA, H/ACA box 50D Neighboring gene cyclin B1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5499, FLJ12496, FLJ12756

Gene Ontology Provided by GOA

Function Evidence Code Pubs
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cellular zinc ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cobalt ion transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of proton transport NAS
Non-traceable Author Statement
more info
PubMed 
response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
zinc ion transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
zinc transporter 5
Names
solute carrier family 30 (zinc transporter), member 5
zinc transporter ZTL1
znT-like transporter 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030415.2 RefSeqGene

    Range
    5066..42121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001251969.2NP_001238898.1  zinc transporter 5 isoform 3

    See identical proteins and their annotated locations for NP_001238898.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region, differs in the 3' UTR and lacks a large portion of the coding region, compared to variant 1. The encoded isoform (3) is significantly shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC017441, BC144349, DB090660
    Consensus CDS
    CCDS58955.1
    UniProtKB/Swiss-Prot
    Q8TAD4
    Related
    ENSP00000421251.1, ENST00000502979.1
  2. NM_022902.5NP_075053.2  zinc transporter 5 isoform 1

    See identical proteins and their annotated locations for NP_075053.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL833716, BX537394, DB090660
    Consensus CDS
    CCDS3996.1
    UniProtKB/Swiss-Prot
    Q8TAD4
    Related
    ENSP00000379836.3, ENST00000396591.8
    Conserved Domains (2) summary
    TIGR01297
    Location:428729
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:428649
    Cation_efflux; Cation efflux family
  3. NM_024055.5NP_076960.1  zinc transporter 5 isoform 2

    See identical proteins and their annotated locations for NP_076960.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and lacks a large portion of the coding region, compared to variant 1. The encoded isoform (2) is significantly shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC017441, DB090660
    Consensus CDS
    CCDS34173.1
    UniProtKB/Swiss-Prot
    Q8TAD4
    Related
    ENSP00000370241.4, ENST00000380860.8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    69093993..69131069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714672.4XP_006714735.1  zinc transporter 5 isoform X2

    Conserved Domains (2) summary
    COG1230
    Location:412670
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:428649
    Cation_efflux; Cation efflux family
  2. XM_005248569.3XP_005248626.1  zinc transporter 5 isoform X1

    Conserved Domains (2) summary
    TIGR01297
    Location:387688
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:387608
    Cation_efflux; Cation efflux family
  3. XM_017009749.1XP_016865238.1  zinc transporter 5 isoform X3

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