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Slc30a5 solute carrier family 30 (zinc transporter), member 5 [ Mus musculus (house mouse) ]

Gene ID: 69048, updated on 27-Nov-2024

Summary

Official Symbol
Slc30a5provided by MGI
Official Full Name
solute carrier family 30 (zinc transporter), member 5provided by MGI
Primary source
MGI:MGI:1916298
See related
Ensembl:ENSMUSG00000021629 AllianceGenome:MGI:1916298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZNT5; ZTL1; ZnT-5; Zntl1; 1810010K08Rik
Summary
Predicted to enable zinc efflux transmembrane transporter activity and zinc:proton antiporter activity. Predicted to be involved in several processes, including insulin processing; intracellular zinc ion homeostasis; and zinc ion transmembrane transport. Predicted to act upstream of with a positive effect on GPI anchor biosynthetic process. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle membrane; and nuclear lumen. Predicted to be active in Golgi apparatus and cytoplasmic vesicle. Is expressed in craniocervical region bone; submandibular gland primordium; and thoracic segment skeleton. Orthologous to human SLC30A5 (solute carrier family 30 member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 20.1), large intestine adult (RPKM 17.7) and 28 other tissues See more
Orthologs
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Genomic context

See Slc30a5 in Genome Data Viewer
Location:
13 D1; 13 53.23 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100939153..100969988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100802645..100833480, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene centromere protein H Neighboring gene STARR-positive B cell enhancer ABC_E1886 Neighboring gene STARR-seq mESC enhancer starr_35481 Neighboring gene cyclin B1 Neighboring gene STARR-positive B cell enhancer ABC_E4088 Neighboring gene STARR-positive B cell enhancer mm9_chr13:101636328-101636628 Neighboring gene STARR-positive B cell enhancer mm9_chr13:101643385-101643686 Neighboring gene predicted gene, 41040 Neighboring gene STARR-seq mESC enhancer starr_35482 Neighboring gene STARR-positive B cell enhancer ABC_E10810 Neighboring gene predicted gene, 41041

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables zinc:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
acts_upstream_of_positive_effect GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_positive_effect GPI anchor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cobalt ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin processing ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular zinc ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular zinc ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion import into Golgi lumen IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in zinc ion import into Golgi lumen ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion import into Golgi lumen ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in zinc ion import into organelle ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion import into organelle ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within zinc ion transport ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in zinc ion transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in ER to Golgi transport vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ER to Golgi transport vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in Golgi cis cisterna membrane ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi cis cisterna membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proton-coupled zinc antiporter SLC30A5
Names
solute carrier family 30 member 5
zinc transporter 5
zinc transporter like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022885.2NP_075023.2  proton-coupled zinc antiporter SLC30A5

    See identical proteins and their annotated locations for NP_075023.2

    Status: VALIDATED

    Source sequence(s)
    AF461761, AK051183
    Consensus CDS
    CCDS26739.1
    UniProtKB/Swiss-Prot
    Q8BQA0, Q8K315, Q8R4H9
    UniProtKB/TrEMBL
    A0A286YDV6
    Related
    ENSMUSP00000065764.5, ENSMUST00000067246.6
    Conserved Domains (2) summary
    TIGR01297
    Location:426725
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:426645
    Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100939153..100969988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158154.1XP_036014047.1  proton-coupled zinc antiporter SLC30A5 isoform X1

    UniProtKB/TrEMBL
    A0A286YDV6
    Conserved Domains (1) summary
    TIGR01297
    Location:375674
    CDF; cation diffusion facilitator family transporter
  2. XM_011244695.3XP_011242997.1  proton-coupled zinc antiporter SLC30A5 isoform X2

    UniProtKB/TrEMBL
    Q8C2T4
    Conserved Domains (1) summary
    TIGR01297
    Location:331630
    CDF; cation diffusion facilitator family transporter
  3. XM_036158156.1XP_036014049.1  proton-coupled zinc antiporter SLC30A5 isoform X3

    UniProtKB/TrEMBL
    Q9JKN2
    Conserved Domains (1) summary
    TIGR01297
    Location:257556
    CDF; cation diffusion facilitator family transporter
  4. XM_036158155.1XP_036014048.1  proton-coupled zinc antiporter SLC30A5 isoform X2

    UniProtKB/TrEMBL
    Q8C2T4
    Conserved Domains (1) summary
    TIGR01297
    Location:331630
    CDF; cation diffusion facilitator family transporter

RNA

  1. XR_004938064.1 RNA Sequence

  2. XR_382742.4 RNA Sequence