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CERK ceramide kinase [ Homo sapiens (human) ]

Gene ID: 64781, updated on 22-Sep-2022

Summary

Official Symbol
CERKprovided by HGNC
Official Full Name
ceramide kinaseprovided by HGNC
Primary source
HGNC:HGNC:19256
See related
Ensembl:ENSG00000100422 MIM:610307; AllianceGenome:HGNC:19256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LK4; hCERK; dA59H18.2; dA59H18.3
Summary
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in small intestine (RPKM 16.4), duodenum (RPKM 15.6) and 25 other tissues See more
Orthologs
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Genomic context

See CERK in Genome Data Viewer
Location:
22q13.31
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (46684410..46738252, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (47172367..47226215, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (47080307..47134149, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8687 Neighboring gene GRAM domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 10248 Neighboring gene uncharacterized LOC105373077 Neighboring gene TBC1 domain family member 22A Neighboring gene TBC1D22A antisense RNA 1 Neighboring gene uncharacterized LOC105369161

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21430, FLJ23239, KIAA1646, MGC131878, DKFZp434E0211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ceramide kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ceramide kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ceramide kinase activity TAS
Traceable Author Statement
more info
 
enables dihydroceramide kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ceramide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ceramide metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in glycosphingolipid metabolic process TAS
Traceable Author Statement
more info
 
involved_in lipid phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sphingolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ceramide kinase
Names
acylsphingosine kinase
lipid kinase 4
lipid kinase LK4
NP_073603.2
XP_016884398.1
XP_047297416.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022766.6NP_073603.2  ceramide kinase

    See identical proteins and their annotated locations for NP_073603.2

    Status: VALIDATED

    Source sequence(s)
    AL096766, AL118516
    Consensus CDS
    CCDS14077.1
    UniProtKB/Swiss-Prot
    Q8TCT0, Q9UGE5
    UniProtKB/TrEMBL
    A0A024R4U8
    Related
    ENSP00000216264.8, ENST00000216264.13
    Conserved Domains (1) summary
    PLN02204
    Location:55528
    PLN02204; diacylglycerol kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    46684410..46738252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028909.1XP_016884398.1  ceramide kinase isoform X2

  2. XM_047441460.1XP_047297416.1  ceramide kinase isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    47172367..47226215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182661.1: Suppressed sequence

    Description
    NM_182661.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.