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CERK ceramide kinase [ Homo sapiens (human) ]

Gene ID: 64781, updated on 5-Mar-2024

Summary

Official Symbol
CERKprovided by HGNC
Official Full Name
ceramide kinaseprovided by HGNC
Primary source
HGNC:HGNC:19256
See related
Ensembl:ENSG00000100422 MIM:610307; AllianceGenome:HGNC:19256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LK4; hCERK; dA59H18.2; dA59H18.3
Summary
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in small intestine (RPKM 16.4), duodenum (RPKM 15.6) and 25 other tissues See more
Orthologs
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Genomic context

See CERK in Genome Data Viewer
Location:
22q13.31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (46684410..46738252, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (47172367..47226215, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (47080307..47134149, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1924 Neighboring gene uncharacterized LOC105373075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46947007-46947508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46947509-46948008 Neighboring gene Sharpr-MPRA regulatory region 3871 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46957479-46958230 Neighboring gene Sharpr-MPRA regulatory region 8687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19242 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:46979179-46980168 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:46980169-46981156 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:46982145-46983132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13913 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13914 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13915 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46994829-46995328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:47014315-47015082 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:47017511-47018022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:47023179-47023964 Neighboring gene GRAM domain containing 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:47026702-47027202 Neighboring gene Sharpr-MPRA regulatory region 10248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:47057755-47058338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:47065520-47066020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:47079427-47079928 Neighboring gene Sharpr-MPRA regulatory region 6253 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:47106581-47107780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:47118736-47119253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:47121804-47122304 Neighboring gene uncharacterized LOC105373077 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:47131961-47132534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:47134630-47135288 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:47150047-47150223 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:47157594-47158428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:47164922-47165802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:47165803-47166681 Neighboring gene TBC1D22A divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:47169021-47169535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:47169536-47170051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19259 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:47179260-47179426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19261 Neighboring gene TBC1 domain family member 22A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:47194214-47194714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:47210780-47211732 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:47223143-47223301 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:47298559-47299204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:47304205-47305098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:47305099-47305992 Neighboring gene TBC1D22A antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:47310467-47310968 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:47310969-47311468

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ21430, FLJ23239, KIAA1646, MGC131878, DKFZp434E0211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ceramide kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ceramide kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ceramide kinase activity TAS
Traceable Author Statement
more info
 
enables dihydroceramide kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ceramide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ceramide metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in glycosphingolipid biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ceramide kinase
Names
acylsphingosine kinase
lipid kinase 4
lipid kinase LK4
NP_073603.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022766.6NP_073603.2  ceramide kinase

    See identical proteins and their annotated locations for NP_073603.2

    Status: VALIDATED

    Source sequence(s)
    AL096766, AL118516
    Consensus CDS
    CCDS14077.1
    UniProtKB/Swiss-Prot
    A0JNT4, A8K611, Q6NX59, Q8TCT0, Q9BYB3, Q9UGE5
    Related
    ENSP00000216264.8, ENST00000216264.13
    Conserved Domains (1) summary
    PLN02204
    Location:55528
    PLN02204; diacylglycerol kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    46684410..46738252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    47172367..47226215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182661.1: Suppressed sequence

    Description
    NM_182661.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.