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Cerk ceramide kinase [ Mus musculus (house mouse) ]

Gene ID: 223753, updated on 9-Mar-2023

Summary

Official Symbol
Cerkprovided by MGI
Official Full Name
ceramide kinaseprovided by MGI
Primary source
MGI:MGI:2386052
See related
Ensembl:ENSMUSG00000035891 AllianceGenome:MGI:2386052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1646; D330016D08Rik
Summary
Enables ceramide kinase activity. Predicted to be involved in ceramide metabolic process and phosphorylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human CERK (ceramide kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 55.0), cerebellum adult (RPKM 36.2) and 25 other tissues See more
Orthologs
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Genomic context

See Cerk in Genome Data Viewer
Location:
15; 15 E2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (86023302..86070537, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (86139101..86186259, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41375 Neighboring gene GRAM domain containing 4 Neighboring gene predicted gene 15722 Neighboring gene predicted gene 15569 Neighboring gene TBC1 domain family, member 22a Neighboring gene predicted gene, 22818 Neighboring gene predicted gene, 34965

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ceramide kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ceramide kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ceramide kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ceramide kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables dihydroceramide kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ceramide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ceramide kinase
Names
acylsphingosine kinase
mCERK
NP_663450.3
XP_011243890.1
XP_030104368.1
XP_030104369.1
XP_036015253.1
XP_036015254.1
XP_036015255.1
XP_036015256.1
XP_036015257.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145475.4NP_663450.3  ceramide kinase

    See identical proteins and their annotated locations for NP_663450.3

    Status: VALIDATED

    Source sequence(s)
    AC116764, AK042077, AK052269, BU756835
    Consensus CDS
    CCDS27728.1
    UniProtKB/Swiss-Prot
    Q52KP2, Q8K4Q7
    Related
    ENSMUSP00000038203.10, ENSMUST00000044332.16
    Conserved Domains (1) summary
    PLN02204
    Location:84528
    PLN02204; diacylglycerol kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    86023302..86070537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159362.1XP_036015255.1  ceramide kinase isoform X4

    Related
    ENSMUST00000150767.8
    Conserved Domains (1) summary
    cl01255
    Location:7451
    DAGK_cat; Diacylglycerol kinase catalytic domain
  2. XM_011245588.4XP_011243890.1  ceramide kinase isoform X3

    Conserved Domains (1) summary
    PLN02204
    Location:84477
    PLN02204; diacylglycerol kinase
  3. XM_030248509.2XP_030104369.1  ceramide kinase isoform X8

    Conserved Domains (1) summary
    cl01255
    Location:20279
    DAGK_cat; Diacylglycerol kinase catalytic domain
  4. XM_030248508.2XP_030104368.1  ceramide kinase isoform X7

    Conserved Domains (1) summary
    PLN02204
    Location:20330
    PLN02204; diacylglycerol kinase
  5. XM_036159361.1XP_036015254.1  ceramide kinase isoform X2

    Conserved Domains (1) summary
    cl01255
    Location:84415
    DAGK_cat; Diacylglycerol kinase catalytic domain
  6. XM_036159363.1XP_036015256.1  ceramide kinase isoform X5

    Conserved Domains (1) summary
    cl01255
    Location:20268
    DAGK_cat; Diacylglycerol kinase catalytic domain
  7. XM_036159360.1XP_036015253.1  ceramide kinase isoform X1

    Conserved Domains (1) summary
    cl01255
    Location:84466
    DAGK_cat; Diacylglycerol kinase catalytic domain
  8. XM_036159364.1XP_036015257.1  ceramide kinase isoform X6

    Conserved Domains (1) summary
    cl01255
    Location:84331
    DAGK_cat; Diacylglycerol kinase catalytic domain