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PARP12 poly(ADP-ribose) polymerase family member 12 [ Homo sapiens (human) ]

Gene ID: 64761, updated on 20-Jan-2019

Summary

Official Symbol
PARP12provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 12provided by HGNC
Primary source
HGNC:HGNC:21919
See related
Ensembl:ENSG00000059378 MIM:612481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZC3H1; ARTD12; MST109; MSTP109; ZC3HDC1
Expression
Ubiquitous expression in duodenum (RPKM 11.7), small intestine (RPKM 11.3) and 25 other tissues See more
Orthologs

Genomic context

See PARP12 in Genome Data Viewer
Location:
7q34
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (140023744..140063721, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (139723544..139764086, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene thromboxane A synthase 1 Neighboring gene uncharacterized LOC107986853 Neighboring gene uncharacterized LOC105375532 Neighboring gene lysine demethylase 7A Neighboring gene KDM7A divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22693

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP12; poly [ADP-ribose] polymerase 12
Names
ADP-ribosyltransferase diphtheria toxin-like 12
zinc finger CCCH type domain containing 1
NP_073587.1
XP_005250095.1
XP_005250096.1
XP_005250097.1
XP_011514793.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022750.3NP_073587.1  protein mono-ADP-ribosyltransferase PARP12

    See identical proteins and their annotated locations for NP_073587.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AA587898, AL137255, BC081541
    Consensus CDS
    CCDS5857.1
    UniProtKB/Swiss-Prot
    Q9H0J9
    UniProtKB/TrEMBL
    A4D1T0
    Related
    ENSP00000263549.3, ENST00000263549.7
    Conserved Domains (3) summary
    smart00678
    Location:299372
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    smart00356
    Location:177200
    ZnF_C3H1; zinc finger
    cd01439
    Location:561677
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

RNA

  1. NR_130117.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA587898, AL137255, BC044660, BC081541

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    140023744..140063721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516491.2XP_011514793.1  poly [ADP-ribose] polymerase 12 isoform X1

    Conserved Domains (3) summary
    smart00678
    Location:299372
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    smart00356
    Location:177200
    ZnF_C3H1; zinc finger
    pfam02825
    Location:377458
    WWE; WWE domain
  2. XM_005250038.3XP_005250095.1  poly [ADP-ribose] polymerase 12 isoform X2

    Conserved Domains (3) summary
    smart00678
    Location:299372
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    smart00356
    Location:177200
    ZnF_C3H1; zinc finger
    pfam02825
    Location:377458
    WWE; WWE domain
  3. XM_005250039.4XP_005250096.1  poly [ADP-ribose] polymerase 12 isoform X3

    See identical proteins and their annotated locations for XP_005250096.1

    UniProtKB/TrEMBL
    G5E9U9
    Related
    ENSP00000417730.1, ENST00000473341.5
    Conserved Domains (2) summary
    smart00678
    Location:299372
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    smart00356
    Location:177200
    ZnF_C3H1; zinc finger
  4. XM_005250040.4XP_005250097.1  poly [ADP-ribose] polymerase 12 isoform X4

    Conserved Domains (2) summary
    smart00678
    Location:299372
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    smart00356
    Location:177200
    ZnF_C3H1; zinc finger

RNA

  1. XR_001744855.1 RNA Sequence

  2. XR_927514.2 RNA Sequence

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