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PARP12 poly(ADP-ribose) polymerase family member 12 [ Homo sapiens (human) ]

Gene ID: 64761, updated on 22-Sep-2022

Summary

Official Symbol
PARP12provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 12provided by HGNC
Primary source
HGNC:HGNC:21919
See related
Ensembl:ENSG00000059378 MIM:612481; AllianceGenome:HGNC:21919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZC3H1; ARTD12; MST109; MSTP109; ZC3HDC1
Summary
Enables protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum (RPKM 11.7), small intestine (RPKM 11.3) and 25 other tissues See more
Orthologs
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Genomic context

See PARP12 in Genome Data Viewer
Location:
7q34
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (140023749..140062951, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (141337341..141376536, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (139723549..139762751, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene thromboxane A synthase 1 Neighboring gene Sharpr-MPRA regulatory region 12519 Neighboring gene uncharacterized LOC105375532 Neighboring gene uncharacterized LOC124901757 Neighboring gene lysine demethylase 7A Neighboring gene Sharpr-MPRA regulatory region 991

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22693

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD+- protein-cysteine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD+-protein ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP12
Names
ADP-ribosyltransferase diphtheria toxin-like 12
poly [ADP-ribose] polymerase 12
zinc finger CCCH type domain containing 1
NP_073587.1
XP_005250095.1
XP_005250096.1
XP_005250097.1
XP_047276695.1
XP_047276697.1
XP_047276698.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022750.4NP_073587.1  protein mono-ADP-ribosyltransferase PARP12

    See identical proteins and their annotated locations for NP_073587.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AC004849, AC004961, AC025816
    Consensus CDS
    CCDS5857.1
    UniProtKB/Swiss-Prot
    Q9H0J9, Q9NTI3
    UniProtKB/TrEMBL
    A4D1T0
    Related
    ENSP00000263549.3, ENST00000263549.8
    Conserved Domains (3) summary
    smart00678
    Location:299372
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    smart00356
    Location:177200
    ZnF_C3H1; zinc finger
    cd01439
    Location:561677
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

RNA

  1. NR_130117.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC004849, AC004961, AC025816

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    140023749..140062951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420739.1XP_047276695.1  protein mono-ADP-ribosyltransferase PARP12 isoform X1

  2. XM_047420741.1XP_047276697.1  protein mono-ADP-ribosyltransferase PARP12 isoform X2

  3. XM_047420742.1XP_047276698.1  protein mono-ADP-ribosyltransferase PARP12 isoform X4

    UniProtKB/TrEMBL
    G5E9U9
    Related
    ENSP00000417730.1, ENST00000473341.5
  4. XM_005250038.4XP_005250095.1  protein mono-ADP-ribosyltransferase PARP12 isoform X3

    Conserved Domains (3) summary
    smart00678
    Location:299372
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    smart00356
    Location:177200
    ZnF_C3H1; zinc finger
    pfam18606
    Location:567
    HTH_53; Zap helix turn helix N-terminal domain
  5. XM_005250039.5XP_005250096.1  protein mono-ADP-ribosyltransferase PARP12 isoform X4

    See identical proteins and their annotated locations for XP_005250096.1

    UniProtKB/TrEMBL
    G5E9U9
    Conserved Domains (3) summary
    smart00678
    Location:299372
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    smart00356
    Location:177200
    ZnF_C3H1; zinc finger
    pfam18606
    Location:567
    HTH_53; Zap helix turn helix N-terminal domain
  6. XM_005250040.5XP_005250097.1  protein mono-ADP-ribosyltransferase PARP12 isoform X5

    Conserved Domains (3) summary
    smart00678
    Location:299372
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    smart00356
    Location:177200
    ZnF_C3H1; zinc finger
    pfam18606
    Location:567
    HTH_53; Zap helix turn helix N-terminal domain

RNA

  1. XR_927514.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    141337341..141376536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)