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SHB SH2 domain containing adaptor protein B [ Homo sapiens (human) ]

Gene ID: 6461, updated on 1-Jun-2020

Summary

Official Symbol
SHBprovided by HGNC
Official Full Name
SH2 domain containing adaptor protein Bprovided by HGNC
Primary source
HGNC:HGNC:10838
See related
Ensembl:ENSG00000107338 MIM:600314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bA3J10.2
Expression
Ubiquitous expression in liver (RPKM 4.9), kidney (RPKM 3.8) and 25 other tissues See more
Orthologs

Genomic context

See SHB in Genome Data Viewer
Location:
9p13.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (37915898..38069227, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37915895..38069210, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 10 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 5 Neighboring gene solute carrier family 25 member 51 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase pseudogene 1 Neighboring gene thioredoxin related transmembrane protein 2 pseudogene 1 Neighboring gene RNA, U7 small nuclear 124 pseudogene Neighboring gene Sharpr-MPRA regulatory region 2787 Neighboring gene VISTA enhancer hs2062 Neighboring gene Sharpr-MPRA regulatory region 8558 Neighboring gene uncharacterized LOC105376039 Neighboring gene uncharacterized LOC107987064

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
NHGRI GWA Catalog
Voxelwise genome-wide association study (vGWAS).
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38908

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SH2 domain-containing adapter protein B
Names
SHB (Src homology 2 domain containing) adaptor protein B
SHB adaptor protein (a Src homology 2 protein)
Src homology 2 domain containing adaptor protein B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003028.3NP_003019.2  SH2 domain-containing adapter protein B

    See identical proteins and their annotated locations for NP_003019.2

    Status: VALIDATED

    Source sequence(s)
    AL138752, AL161448, AL583849
    Consensus CDS
    CCDS43806.1
    UniProtKB/Swiss-Prot
    Q15464
    Related
    ENSP00000366936.3, ENST00000377707.4
    Conserved Domains (1) summary
    cd10389
    Location:408504
    SH2_SHB; Src homology 2 domain found in SH2 domain-containing adapter protein B (SHB)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    37915898..38069227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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