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SHB SH2 domain containing adaptor protein B [ Homo sapiens (human) ]

Gene ID: 6461, updated on 5-Aug-2022

Summary

Official Symbol
SHBprovided by HGNC
Official Full Name
SH2 domain containing adaptor protein Bprovided by HGNC
Primary source
HGNC:HGNC:10838
See related
Ensembl:ENSG00000107338 MIM:600314; AllianceGenome:HGNC:10838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bA3J10.2
Summary
Enables phosphotyrosine residue binding activity. Predicted to be involved in several processes, including angiogenesis; apoptotic process; and signal transduction. Predicted to act upstream of or within several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver (RPKM 4.9), kidney (RPKM 3.8) and 25 other tissues See more
Orthologs
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Genomic context

See SHB in Genome Data Viewer
Location:
9p13.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (37915898..38069227, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (37939809..38093156, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37915895..38069224, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 10 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 5 Neighboring gene solute carrier family 25 member 51 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase pseudogene 1 Neighboring gene thioredoxin related transmembrane protein 2 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 877 Neighboring gene RNA, U7 small nuclear 124 pseudogene Neighboring gene Sharpr-MPRA regulatory region 5136 Neighboring gene Sharpr-MPRA regulatory region 8282 Neighboring gene Sharpr-MPRA regulatory region 2787 Neighboring gene VISTA enhancer hs2062 Neighboring gene Sharpr-MPRA regulatory region 8558 Neighboring gene uncharacterized LOC105376039 Neighboring gene Sharpr-MPRA regulatory region 13386

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
EBI GWAS Catalog
Voxelwise genome-wide association study (vGWAS).
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38908

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in hematopoietic stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of oocyte maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T-helper cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SH2 domain-containing adapter protein B
Names
SHB (Src homology 2 domain containing) adaptor protein B
SHB adaptor protein (a Src homology 2 protein)
Src homology 2 domain containing adaptor protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003028.3NP_003019.2  SH2 domain-containing adapter protein B

    See identical proteins and their annotated locations for NP_003019.2

    Status: VALIDATED

    Source sequence(s)
    AL138752, AL161448, AL583849
    Consensus CDS
    CCDS43806.1
    UniProtKB/Swiss-Prot
    Q15464, Q5VUM8
    Related
    ENSP00000366936.3, ENST00000377707.4
    Conserved Domains (1) summary
    cd10389
    Location:408504
    SH2_SHB; Src homology 2 domain found in SH2 domain-containing adapter protein B (SHB)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    37915898..38069227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    37939809..38093156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)