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SLC25A51 solute carrier family 25 member 51 [ Homo sapiens (human) ]

Gene ID: 92014, updated on 22-Sep-2022

Summary

Official Symbol
SLC25A51provided by HGNC
Official Full Name
solute carrier family 25 member 51provided by HGNC
Primary source
HGNC:HGNC:23323
See related
Ensembl:ENSG00000122696 MIM:619153; AllianceGenome:HGNC:23323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CG7943; MCART1
Summary
Enables NAD transmembrane transporter activity. Involved in mitochondrial NAD transmembrane transport. Located in mitochondrion. Is active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 3.6), testis (RPKM 1.8) and 25 other tissues See more
Orthologs
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Genomic context

See SLC25A51 in Genome Data Viewer
Location:
9p13.2-p13.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (37877575..37904127, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (37901485..37928037, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37877572..37904124, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376037 Neighboring gene DDB1 and CUL4 associated factor 10 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 5 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase pseudogene 1 Neighboring gene thioredoxin related transmembrane protein 2 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 877 Neighboring gene RNA, U7 small nuclear 124 pseudogene Neighboring gene SH2 domain containing adaptor protein B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37273, MGC14836

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51
Names
mitochondrial NAD(+) transporter SLC25A51
mitochondrial NAD+ transporter
mitochondrial carrier triple repeat 1
mitochondrial carrier triple repeat protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033412.4NP_219480.1  mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

    See identical proteins and their annotated locations for NP_219480.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the functional protein.
    Source sequence(s)
    AL138752, BG953457
    Consensus CDS
    CCDS6614.1
    UniProtKB/Swiss-Prot
    Q9H1U9
    Related
    ENSP00000242275.6, ENST00000242275.7
    Conserved Domains (1) summary
    pfam00153
    Location:31112
    Mito_carr; Mitochondrial carrier protein

RNA

  1. NR_024872.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains 3 alternate exons in the 5' and 3' regions and lacks the coding exon, compared to variant 1. This variant is represented as non-coding because it completely lacks the coding region found in variant 1.
    Source sequence(s)
    AK091407, AK098185, AL138752, KF459922
  2. NR_024873.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains 2 alternate exons at the 3' end and lacks the coding exon, compared to variant 1. This variant is represented as non-coding because it completely lacks the coding region found in variant 1.
    Source sequence(s)
    AK098185, AL138752, BC063563, KF459922

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    37877575..37904127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    37901485..37928037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)