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TOMM5 translocase of outer mitochondrial membrane 5 [ Homo sapiens (human) ]

Gene ID: 401505, updated on 2-Mar-2021

Summary

Official Symbol
TOMM5provided by HGNC
Official Full Name
translocase of outer mitochondrial membrane 5provided by HGNC
Primary source
HGNC:HGNC:31369
See related
Ensembl:ENSG00000175768 MIM:616169
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Tom5; C9orf105; bA613M10.3
Expression
Ubiquitous expression in kidney (RPKM 28.8), colon (RPKM 28.3) and 25 other tissues See more
Orthologs
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Genomic context

See TOMM5 in Genome Data Viewer
Location:
9p13.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (37588413..37592597, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37588410..37592594, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 83 Neighboring gene RNA polymerase I subunit E Neighboring gene F-box protein 10 Neighboring gene FERM and PDZ domain containing 1 Neighboring gene RAB1C, member RAS oncogene family pseudogene Neighboring gene RN7SK pseudogene 171

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
macroautophagy TAS
Traceable Author Statement
more info
 
protein targeting to mitochondrion IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrial outer membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane translocase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mitochondrial import receptor subunit TOM5 homolog
Names
mitochondrial outer membrane protein TOM5
translocase of outer mitochondrial membrane 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001790.3NP_001001790.1  mitochondrial import receptor subunit TOM5 homolog isoform 1

    See identical proteins and their annotated locations for NP_001001790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1).
    Source sequence(s)
    BC029423, BC034247, DB451927
    Consensus CDS
    CCDS43803.1
    UniProtKB/Swiss-Prot
    Q8N4H5
    Related
    ENSP00000313584.6, ENST00000321301.7
    Conserved Domains (1) summary
    pfam10642
    Location:150
    Tom5; Mitochondrial import receptor subunit or translocase
  2. NM_001134484.2NP_001127956.1  mitochondrial import receptor subunit TOM5 homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site at the 3' end of the first coding exon, compared to variant 1, which results in a protein (isoform 3) with a longer and distinct C-terminus when compared to isoform 1.
    Source sequence(s)
    BC029423, BM693831, DB451927
    Consensus CDS
    CCDS47968.1
    UniProtKB/Swiss-Prot
    Q8N4H5
    Related
    ENSP00000438204.1, ENST00000544379.1
    Conserved Domains (1) summary
    pfam15178
    Location:141
    TOM_sub5; Mitochondrial import receptor subunit TOM5 homolog
  3. NM_001134485.2NP_001127957.1  mitochondrial import receptor subunit TOM5 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate in-frame splice site at the 3' end of the first coding exon, compared to variant 1, which results in a protein (isoform 2) with 34 additional amino acids when compared to isoform 1.
    Source sequence(s)
    BC029423, DB451927
    Consensus CDS
    CCDS47967.1
    UniProtKB/Swiss-Prot
    Q8N4H5
    Related
    ENSP00000367004.5, ENST00000377773.9
    Conserved Domains (1) summary
    pfam15178
    Location:185
    TOM_sub5; Mitochondrial import receptor subunit TOM5 homolog

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    37588413..37592597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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