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SEBOX SEBOX homeobox [ Homo sapiens (human) ]

Gene ID: 645832, updated on 25-Nov-2021


Official Symbol
SEBOXprovided by HGNC
Official Full Name
SEBOX homeoboxprovided by HGNC
Primary source
See related
Ensembl:ENSG00000274529 MIM:610975
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OG9; OG-9; OG9X
Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development (Cinquanta et al., 2000 [PubMed 10922053]).[supplied by OMIM, Mar 2008]
Low expression observed in reference dataset See more
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Genomic context

See SEBOX in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28363506..28365199, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26691290..26692173, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TNF alpha induced protein 1 Neighboring gene DNA polymerase delta interacting protein 2 Neighboring gene transmembrane protein 199 Neighboring gene microRNA 4723 Neighboring gene vitronectin Neighboring gene sterile alpha and TIR motif containing 1 Neighboring gene solute carrier family 46 member 1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SEBOX homeobox by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

General gene information


Potential readthrough

Included gene: VTN


Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IEA
Inferred from Electronic Annotation
more info
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
located_in nucleus IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
homeobox protein SEBOX
homeobox OG-9
skin-, embryo-, brain- and oocyte-specific homeobox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080837.4NP_001074306.3  homeobox protein SEBOX

    Status: VALIDATED

    Source sequence(s)
    AC002094, KF573650
    Consensus CDS
    ENSP00000444503.3, ENST00000536498.5
    Conserved Domains (1) summary
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    28363506..28365199 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001083896.1: Suppressed sequence

    NM_001083896.1: This RefSeq was permanently suppressed because it represents a read-through transcript between VTN (GeneID 7448) and SEBOX (GeneID 645832) and currently there is insufficient support for the transcript and the protein.
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