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SEBOX SEBOX homeobox [ Homo sapiens (human) ]

Gene ID: 645832, updated on 1-Jun-2020

Summary

Official Symbol
SEBOXprovided by HGNC
Official Full Name
SEBOX homeoboxprovided by HGNC
Primary source
HGNC:HGNC:32942
See related
Ensembl:ENSG00000274529 MIM:610975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OG9; OG-9; OG9X
Summary
Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development (Cinquanta et al., 2000 [PubMed 10922053]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See SEBOX in Genome Data Viewer
Location:
17q11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28364268..28365151, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26691290..26692265, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TNF alpha induced protein 1 Neighboring gene DNA polymerase delta interacting protein 2 Neighboring gene transmembrane protein 199 Neighboring gene microRNA 4723 Neighboring gene vitronectin Neighboring gene sterile alpha and TIR motif containing 1 Neighboring gene solute carrier family 46 member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SEBOX homeobox by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Potential readthrough

Included gene: VTN

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
Process Evidence Code Pubs
embryo development ending in birth or egg hatching IEA
Inferred from Electronic Annotation
more info
 
oogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II ISA
Inferred from Sequence Alignment
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
homeobox protein SEBOX
Names
homeobox OG-9
skin-, embryo-, brain- and oocyte-specific homeobox

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080837.3NP_001074306.3  homeobox protein SEBOX

    Status: VALIDATED

    Source sequence(s)
    AC002094, KF573650
    Consensus CDS
    CCDS45634.2
    UniProtKB/TrEMBL
    F6T8T6
    Related
    ENSP00000444503.3, ENST00000536498.5
    Conserved Domains (1) summary
    pfam00046
    Location:2273
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    28364268..28365151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001083896.1: Suppressed sequence

    Description
    NM_001083896.1: This RefSeq was permanently suppressed because it represents a read-through transcript between VTN (GeneID 7448) and SEBOX (GeneID 645832) and currently there is insufficient support for the transcript and the protein.
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