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VTN vitronectin [ Homo sapiens (human) ]

Gene ID: 7448, updated on 6-May-2021

Summary

Official Symbol
VTNprovided by HGNC
Official Full Name
vitronectinprovided by HGNC
Primary source
HGNC:HGNC:12724
See related
Ensembl:ENSG00000109072 MIM:193190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VN; V75; VNT
Summary
The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein. [provided by RefSeq, Aug 2020]
Expression
Restricted expression toward liver (RPKM 1572.2) See more
Orthologs
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Genomic context

See VTN in Genome Data Viewer
Location:
17q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28367284..28370307, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26694305..26697328, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 199 Neighboring gene microRNA 4723 Neighboring gene SEBOX homeobox Neighboring gene sterile alpha and TIR motif containing 1 Neighboring gene solute carrier family 46 member 1 Neighboring gene H3 histone pseudogene 41

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of vitronectin (VTN) expression as compared to untreated control PubMed
env Interaction of S-protein (vitronectin) with HIV-1 gp120 and CD4 is mediated by heparin PubMed
Tat tat HIV-1 Tat competes with vitronectin for binding to integrins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: SEBOX

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables extracellular matrix structural constituent ISS
Inferred from Sequence or Structural Similarity
more info
 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables polysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell adhesion TAS
Traceable Author Statement
more info
PubMed 
involved_in cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-matrix adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extracellular matrix organization TAS
Traceable Author Statement
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood coagulation IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of wound healing IC
Inferred by Curator
more info
PubMed 
involved_in regulation of complement activation TAS
Traceable Author Statement
more info
 
involved_in smooth muscle cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vitronectin
Names
complement S-protein
epibolin
serum spreading factor
somatomedin B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000638.4NP_000629.3  vitronectin precursor

    See identical proteins and their annotated locations for NP_000629.3

    Status: REVIEWED

    Source sequence(s)
    AI352496, BC005046, BG470977
    Consensus CDS
    CCDS11229.1
    UniProtKB/Swiss-Prot
    P04004
    UniProtKB/TrEMBL
    D9ZGG2
    Related
    ENSP00000226218.4, ENST00000226218.9
    Conserved Domains (2) summary
    smart00201
    Location:2062
    SO; Somatomedin B -like domains
    cd00094
    Location:154472
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    28367284..28370307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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