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ITSN1 intersectin 1 [ Homo sapiens (human) ]

Gene ID: 6453, updated on 3-Jan-2019

Summary

Official Symbol
ITSN1provided by HGNC
Official Full Name
intersectin 1provided by HGNC
Primary source
HGNC:HGNC:6183
See related
Ensembl:ENSG00000205726 MIM:602442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ITSN; SH3D1A; SH3P17
Summary
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 8.8), brain (RPKM 4.1) and 24 other tissues See more
Orthologs

Genomic context

See ITSN1 in Genome Data Viewer
Location:
21q22.11
Exon count:
43
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 21 NC_000021.9 (33642400..33899861)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (35014706..35261609)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene downstream neighbor of SON Neighboring gene crystallin zeta like 1 Neighboring gene RNA, 7SL, cytoplasmic 740, pseudogene Neighboring gene ATP synthase peripheral stalk subunit OSCP

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2018-06-27)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated (2018-06-27)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies ITSN1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemRecruitment of plasma membrane-localized cargo into clathrin-coated endocytic vesicles is mediated by interaction with a variety of clathrin-interacting proteins collectively called CLASPs (clathrin-...
  • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
    Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
  • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
  • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHB forward signaling, organism-specific biosystem
    EPHB forward signaling
  • EPHB-mediated forward signaling, organism-specific biosystem (from REACTOME)
    EPHB-mediated forward signaling, organism-specific biosystemMultiple EPHB receptors contribute directly to dendritic spine development and morphogenesis. These are more broadly involved in post-synaptic development through activation of focal adhesion kinase ...
  • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
    Internalization of ErbB1, organism-specific biosystem
    Internalization of ErbB1
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
    NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
  • Regulation of CDC42 activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of CDC42 activity, organism-specific biosystem
    Regulation of CDC42 activity
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
    p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC134948, MGC134949

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
guanyl-nucleotide exchange factor activity NAS
Non-traceable Author Statement
more info
PubMed 
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
proline-rich region binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex scaffold activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
calyx of Held IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic endocytic zone IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
intersectin-1
Names
SH3 domain-containing protein 1A
Src homology 3 domain-containing protein
human intersectin-SH3 domain-containing protein SH3P17
intersectin 1 (SH3 domain protein)
intersectin 1 short form variant 3
intersectin 1 short form variant, 11
intersectin short variant 12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029504.1 RefSeqGene

    Range
    5001..251826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001132.1NP_001001132.1  intersectin-1 isoform ITSN-s

    See identical proteins and their annotated locations for NP_001001132.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (ITSN-s) is shorter at the C-terminus compared to isoform ITSN-l.
    Source sequence(s)
    AF114488, AI857585, BC058925
    Consensus CDS
    CCDS33546.1
    UniProtKB/Swiss-Prot
    Q15811
    UniProtKB/TrEMBL
    Q6PD56
    Related
    ENSP00000370691.4, ENST00000381291.8
    Conserved Domains (10) summary
    smart00027
    Location:214309
    EH; Eps15 homology domain
    cd11991
    Location:10061057
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11995
    Location:11581211
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1340
    Location:372686
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:225291
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam13476
    Location:509636
    AAA_23; AAA domain
    pfam16617
    Location:803917
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:383394
    GBP_C; coiled coil [structural motif]
    cl17036
    Location:10741138
    SH3; Src Homology 3 domain superfamily
    cl20817
    Location:331414
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_001331008.1NP_001317937.1  intersectin-1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AK027846, AP000308, AP000311, AP000312, CX163355, KF511399
    Consensus CDS
    CCDS82661.1
    UniProtKB/TrEMBL
    F8W7U0
    Related
    ENSP00000382292.2, ENST00000399355.6
  3. NM_001331009.1NP_001317938.1  intersectin-1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AK027846, AK300274, AP000312, CX163355
    Consensus CDS
    CCDS82663.1
    UniProtKB/Swiss-Prot
    Q15811
    Related
    ENSP00000382289.1, ENST00000399352.5
    Conserved Domains (11) summary
    smart00027
    Location:214309
    EH; Eps15 homology domain
    cd11987
    Location:744798
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11991
    Location:10011052
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11995
    Location:11531206
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1340
    Location:372686
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:225291
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam13476
    Location:509636
    AAA_23; AAA domain
    pfam16617
    Location:798912
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:383394
    GBP_C; coiled coil [structural motif]
    cl17036
    Location:10691133
    SH3; Src Homology 3 domain superfamily
    cl20817
    Location:331414
    GBP_C; Guanylate-binding protein, C-terminal domain
  4. NM_001331010.1NP_001317939.1  intersectin-1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK027846, AP000308, AP000311, AP000312, AP000313, KF511399
    Consensus CDS
    CCDS82664.1
    UniProtKB/Swiss-Prot
    Q15811
    Related
    ENSP00000382301.3, ENST00000399367.7
    Conserved Domains (16) summary
    cd08375
    Location:15771711
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:214309
    EH; Eps15 homology domain
    cd11987
    Location:744798
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:912963
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:10011052
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:10691133
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:11531206
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1340
    Location:372686
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:225291
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd13264
    Location:14431574
    PH_ITSN; Intersectin Pleckstrin homology (PH) domain
    pfam00169
    Location:14601566
    PH; PH domain
    pfam00621
    Location:12371417
    RhoGEF; RhoGEF domain
    pfam13476
    Location:509636
    AAA_23; AAA domain
    pfam16617
    Location:798912
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:383394
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:331414
    GBP_C; Guanylate-binding protein, C-terminal domain
  5. NM_001331011.1NP_001317940.1  intersectin-1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AK027846, AP000312, BC117560, CX163355
    Consensus CDS
    CCDS82665.1
    UniProtKB/Swiss-Prot
    Q15811
    Related
    ENSP00000382286.1, ENST00000399349.5
    Conserved Domains (10) summary
    smart00027
    Location:214309
    EH; Eps15 homology domain
    cd11987
    Location:744798
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11995
    Location:10821135
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1340
    Location:372686
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:225291
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam13476
    Location:509636
    AAA_23; AAA domain
    pfam16617
    Location:798912
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:383394
    GBP_C; coiled coil [structural motif]
    cl17036
    Location:10011062
    SH3; Src Homology 3 domain superfamily
    cl20817
    Location:331414
    GBP_C; Guanylate-binding protein, C-terminal domain
  6. NM_001331012.1NP_001317941.1  intersectin-1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AK027846, AP000308, AP000311, AP000312, CX163355, KF511399
    Consensus CDS
    CCDS82666.1
    UniProtKB/Swiss-Prot
    Q15811
    Related
    ENSP00000382290.1, ENST00000399353.5
    Conserved Domains (11) summary
    smart00027
    Location:177272
    EH; Eps15 homology domain
    cd11987
    Location:707761
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11991
    Location:9641015
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11995
    Location:11161169
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1340
    Location:335649
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:188254
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam13476
    Location:472599
    AAA_23; AAA domain
    pfam16617
    Location:761875
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:346357
    GBP_C; coiled coil [structural motif]
    cl17036
    Location:10321096
    SH3; Src Homology 3 domain superfamily
    cl20817
    Location:294377
    GBP_C; Guanylate-binding protein, C-terminal domain
  7. NM_003024.3NP_003015.2  intersectin-1 isoform ITSN-l

    See identical proteins and their annotated locations for NP_003015.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (ITSN-l).
    Source sequence(s)
    AF064244, AF114487, AP000313, BC058925
    Consensus CDS
    CCDS33545.1
    UniProtKB/Swiss-Prot
    Q15811
    UniProtKB/TrEMBL
    Q6PD56
    Related
    ENSP00000370719.3, ENST00000381318.7
    Conserved Domains (16) summary
    cd08375
    Location:15821716
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:214309
    EH; Eps15 homology domain
    cd11987
    Location:744803
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:917968
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:10061057
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:10741138
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:11581211
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1340
    Location:372686
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:225291
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd13264
    Location:14481579
    PH_ITSN; Intersectin Pleckstrin homology (PH) domain
    pfam00169
    Location:14651571
    PH; PH domain
    pfam00621
    Location:12421422
    RhoGEF; RhoGEF domain
    pfam13476
    Location:509636
    AAA_23; AAA domain
    pfam16617
    Location:803917
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:383394
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:331414
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p12 Primary Assembly

    Range
    33642400..33899861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028429.2XP_016883918.1  intersectin-1 isoform X2

  2. XM_017028435.2XP_016883924.1  intersectin-1 isoform X8

  3. XM_017028430.2XP_016883919.1  intersectin-1 isoform X3

  4. XM_017028436.2XP_016883925.1  intersectin-1 isoform X9

  5. XM_017028438.2XP_016883927.1  intersectin-1 isoform X11

    UniProtKB/TrEMBL
    A7XZY7
    Conserved Domains (10) summary
    smart00027
    Location:177272
    EH; Eps15 homology domain
    cd11991
    Location:9691020
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11995
    Location:11211174
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1340
    Location:335649
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:188254
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam13476
    Location:472599
    AAA_23; AAA domain
    pfam16617
    Location:766880
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:346357
    GBP_C; coiled coil [structural motif]
    cl17036
    Location:10371101
    SH3; Src Homology 3 domain superfamily
    cl20817
    Location:294377
    GBP_C; Guanylate-binding protein, C-terminal domain
  6. XM_017028440.2XP_016883929.1  intersectin-1 isoform X12

    UniProtKB/Swiss-Prot
    Q15811
    Conserved Domains (9) summary
    smart00027
    Location:177272
    EH; Eps15 homology domain
    cd11995
    Location:10501103
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1340
    Location:335649
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:188254
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam13476
    Location:472599
    AAA_23; AAA domain
    pfam16617
    Location:766880
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:346357
    GBP_C; coiled coil [structural motif]
    cl17036
    Location:9691030
    SH3; Src Homology 3 domain superfamily
    cl20817
    Location:294377
    GBP_C; Guanylate-binding protein, C-terminal domain
  7. XM_011529692.2XP_011527994.1  intersectin-1 isoform X13

    See identical proteins and their annotated locations for XP_011527994.1

    UniProtKB/Swiss-Prot
    Q15811
    Conserved Domains (10) summary
    smart00027
    Location:177272
    EH; Eps15 homology domain
    cd11987
    Location:707761
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11995
    Location:10451098
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1340
    Location:335649
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:188254
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam13476
    Location:472599
    AAA_23; AAA domain
    pfam16617
    Location:761875
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:346357
    GBP_C; coiled coil [structural motif]
    cl17036
    Location:9641025
    SH3; Src Homology 3 domain superfamily
    cl20817
    Location:294377
    GBP_C; Guanylate-binding protein, C-terminal domain
  8. XM_017028431.2XP_016883920.1  intersectin-1 isoform X4

  9. XM_017028433.2XP_016883922.1  intersectin-1 isoform X6

    UniProtKB/Swiss-Prot
    Q15811
  10. XM_017028432.2XP_016883921.1  intersectin-1 isoform X5

    UniProtKB/Swiss-Prot
    Q15811
    Conserved Domains (16) summary
    cd08375
    Location:15211655
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:214309
    EH; Eps15 homology domain
    cd11987
    Location:744798
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:912963
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:10011052
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:10691133
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:11531206
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1340
    Location:372686
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:225291
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd13264
    Location:13871518
    PH_ITSN; Intersectin Pleckstrin homology (PH) domain
    pfam00169
    Location:14041510
    PH; PH domain
    pfam00621
    Location:12371386
    RhoGEF; RhoGEF domain
    pfam13476
    Location:509636
    AAA_23; AAA domain
    pfam16617
    Location:798912
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:383394
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:331414
    GBP_C; Guanylate-binding protein, C-terminal domain
  11. XM_017028434.2XP_016883923.1  intersectin-1 isoform X7

  12. XM_017028441.2XP_016883930.1  intersectin-1 isoform X14

  13. XM_011529693.3XP_011527995.1  intersectin-1 isoform X15

    UniProtKB/Swiss-Prot
    Q15811
    Related
    ENSP00000382275.4, ENST00000399338.8
    Conserved Domains (8) summary
    smart00027
    Location:214309
    EH; Eps15 homology domain
    cd11987
    Location:744798
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    COG1340
    Location:372686
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:225291
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam13476
    Location:509636
    AAA_23; AAA domain
    pfam16617
    Location:798904
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:383394
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:331414
    GBP_C; Guanylate-binding protein, C-terminal domain
  14. XM_017028428.1XP_016883917.1  intersectin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q15811
    Conserved Domains (16) summary
    cd08375
    Location:15821716
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:214309
    EH; Eps15 homology domain
    cd11987
    Location:744803
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:917968
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:10061057
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:10741138
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:11581211
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1340
    Location:372686
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:225291
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd13264
    Location:14481579
    PH_ITSN; Intersectin Pleckstrin homology (PH) domain
    pfam00169
    Location:14651571
    PH; PH domain
    pfam00621
    Location:12421422
    RhoGEF; RhoGEF domain
    pfam13476
    Location:509636
    AAA_23; AAA domain
    pfam16617
    Location:803917
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:383394
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:331414
    GBP_C; Guanylate-binding protein, C-terminal domain
  15. XM_017028437.1XP_016883926.1  intersectin-1 isoform X10

RNA

  1. XR_001754890.2 RNA Sequence

  2. XR_001754889.2 RNA Sequence

  3. XR_244289.2 RNA Sequence

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