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Itsn1 intersectin 1 (SH3 domain protein 1A) [ Mus musculus (house mouse) ]

Gene ID: 16443, updated on 8-Feb-2024

Summary

Official Symbol
Itsn1provided by MGI
Official Full Name
intersectin 1 (SH3 domain protein 1A)provided by MGI
Primary source
MGI:MGI:1338069
See related
Ensembl:ENSMUSG00000022957 AllianceGenome:MGI:1338069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ese1; Itsn; Ehsh1; Sh3p17
Summary
Enables kinase activator activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within negative regulation of neuron apoptotic process; positive regulation of protein kinase B signaling; and small GTPase mediated signal transduction. Located in several cellular components, including calyx of Held; clathrin-coated pit; and lamellipodium. Is active in presynaptic endocytic zone. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human ITSN1 (intersectin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 7.3), CNS E14 (RPKM 6.7) and 28 other tissues See more
Orthologs
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Genomic context

See Itsn1 in Genome Data Viewer
Location:
16 C4; 16 53.28 cM
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91526198..91717479)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91729310..91920591)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10785 Neighboring gene crystallin zeta like 1 Neighboring gene predicted gene, 46543 Neighboring gene predicted gene, 53921 Neighboring gene predicted gene, 52262 Neighboring gene STARR-positive B cell enhancer ABC_E7476 Neighboring gene predicted gene, 25245 Neighboring gene ATP synthase peripheral stalk subunit OSCP

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of caveolin-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within small GTPase-mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in calyx of Held IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic endocytic zone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
intersectin-1
Names
EH and SH3 domains protein 1
Eh domain, SH3 domain regulator of endocytosis 1
intersectin (SH3 domain protein 1A)
intersectin-L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110275.1NP_001103745.1  intersectin-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 3' end, compared to variant 1. These differences produce a unique 3' UTR and result in a protein (isoform 2) that is shorter at the C-terminus, compared to isoform 1.
    Source sequence(s)
    AF132478, BC062938
    Consensus CDS
    CCDS49913.1
    UniProtKB/TrEMBL
    E9Q3I5
    Related
    ENSMUSP00000056011.8, ENSMUST00000056482.14
    Conserved Domains (11) summary
    smart00027
    Location:214309
    EH; Eps15 homology domain
    cd11987
    Location:742796
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11991
    Location:9991050
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11995
    Location:11511204
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1340
    Location:350646
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:225291
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam16617
    Location:796910
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:677686
    GBP_C; coiled coil [structural motif]
    cl17036
    Location:10671131
    SH3; Src Homology 3 domain superfamily
    cl20817
    Location:615706
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:546646
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_001110276.1NP_001103746.1  intersectin-1 isoform 3

    See identical proteins and their annotated locations for NP_001103746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the presence and absence of exons at its 3' end, compared to variant 1. These differences produce a unique 3' UTR and result in a shorter protein (isoform 3) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC066105, CB519152
    Consensus CDS
    CCDS49914.1
    UniProtKB/TrEMBL
    Q3U2A1, Q6NZJ5
    Related
    ENSMUSP00000093598.4, ENSMUST00000095909.10
    Conserved Domains (4) summary
    smart00027
    Location:214309
    EH; Eps15 homology domain
    cd00052
    Location:225291
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam03957
    Location:93190
    Jun; Jun-like transcription factor
    cl23765
    Location:351465
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  3. NM_010587.2NP_034717.2  intersectin-1 isoform 1

    See identical proteins and their annotated locations for NP_034717.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC126053, AF132481, AK082606, BC062938
    Consensus CDS
    CCDS37402.1
    UniProtKB/Swiss-Prot
    F8VQE5, Q9R143, Q9Z0R4
    Related
    ENSMUSP00000109635.3, ENSMUST00000114002.9
    Conserved Domains (17) summary
    cd08375
    Location:15751709
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:214309
    EH; Eps15 homology domain
    cd11987
    Location:742796
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:910961
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:9991050
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:10671131
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:11511204
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1340
    Location:350646
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00052
    Location:225291
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd13264
    Location:14411572
    PH_ITSN; Intersectin Pleckstrin homology (PH) domain
    pfam00169
    Location:14581564
    PH; PH domain
    pfam00621
    Location:12351415
    RhoGEF; RhoGEF domain
    pfam03957
    Location:93190
    Jun; Jun-like transcription factor
    pfam16617
    Location:796910
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:677686
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:615706
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:546646
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    91526198..91717479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522934.4XP_006522997.1  intersectin-1 isoform X4

    UniProtKB/TrEMBL
    E9Q0N0
    Related
    ENSMUSP00000066361.6, ENSMUST00000064797.12
    Conserved Domains (12) summary
    PTZ00121
    Location:331715
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:15801714
    C2_Intersectin; C2 domain present in Intersectin
    PRK14959
    Location:42184
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    smart00027
    Location:214309
    EH; Eps15 homology domain
    cd11989
    Location:915966
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:10041055
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:10721136
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:11561209
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    cd00160
    Location:12361419
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:801915
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:14381591
    PH_13; Pleckstrin homology domain
    cl17036
    Location:742801
    SH3; Src Homology 3 domain superfamily
  2. XM_036159794.1XP_036015687.1  intersectin-1 isoform X11

    UniProtKB/TrEMBL
    E9Q3I8, E9Q3I9
    Related
    ENSMUSP00000109629.2, ENSMUST00000113996.8
    Conserved Domains (7) summary
    PTZ00121
    Location:331715
    PTZ00121; MAEBL; Provisional
    PRK14959
    Location:42184
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    smart00027
    Location:214309
    EH; Eps15 homology domain
    cd11987
    Location:742796
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11995
    Location:10801133
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    pfam16617
    Location:796910
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:9991060
    SH3; Src Homology 3 domain superfamily
  3. XM_006522931.3XP_006522994.1  intersectin-1 isoform X1

    Conserved Domains (12) summary
    PTZ00121
    Location:355739
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:16041738
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:238333
    EH; Eps15 homology domain
    cd11989
    Location:939990
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:10281079
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:10961160
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:11801233
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    PLN02983
    Location:155226
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    cd00160
    Location:12601443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:825939
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:14621615
    PH_13; Pleckstrin homology domain
    cl17036
    Location:766825
    SH3; Src Homology 3 domain superfamily
  4. XM_006522935.2XP_006522998.1  intersectin-1 isoform X5

    Conserved Domains (11) summary
    PTZ00121
    Location:355739
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:15331667
    C2_Intersectin; C2 domain present in Intersectin
    PRK14959
    Location:66208
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    smart00027
    Location:238333
    EH; Eps15 homology domain
    cd11987
    Location:766825
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:939990
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11995
    Location:11091162
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    cd00160
    Location:11891372
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:825939
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:13911544
    PH_13; Pleckstrin homology domain
    cl17036
    Location:10281089
    SH3; Src Homology 3 domain superfamily
  5. XM_006522933.2XP_006522996.1  intersectin-1 isoform X3

    Conserved Domains (12) summary
    PTZ00121
    Location:355739
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:15991733
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:238333
    EH; Eps15 homology domain
    cd11987
    Location:766820
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:934985
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:10231074
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:10911155
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:11751228
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    PLN02983
    Location:155226
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    cd00160
    Location:12551438
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:820934
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:14571610
    PH_13; Pleckstrin homology domain
  6. XM_006522936.2XP_006522999.1  intersectin-1 isoform X6

    Conserved Domains (11) summary
    PTZ00121
    Location:355739
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:15281662
    C2_Intersectin; C2 domain present in Intersectin
    PRK14959
    Location:66208
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    smart00027
    Location:238333
    EH; Eps15 homology domain
    cd11987
    Location:766820
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:934985
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11995
    Location:11041157
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    cd00160
    Location:11841367
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:820934
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:13861539
    PH_13; Pleckstrin homology domain
    cl17036
    Location:10231084
    SH3; Src Homology 3 domain superfamily
  7. XM_006522938.2XP_006523001.1  intersectin-1 isoform X8

    UniProtKB/TrEMBL
    E9Q3I5
    Conserved Domains (7) summary
    PTZ00121
    Location:355739
    PTZ00121; MAEBL; Provisional
    smart00027
    Location:238333
    EH; Eps15 homology domain
    cd11991
    Location:10281079
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11995
    Location:11801233
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    PLN02983
    Location:155226
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    pfam16617
    Location:825939
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:10961160
    SH3; Src Homology 3 domain superfamily
  8. XM_036159793.1XP_036015686.1  intersectin-1 isoform X10

    UniProtKB/TrEMBL
    E9Q3I9
    Conserved Domains (6) summary
    PTZ00121
    Location:355739
    PTZ00121; MAEBL; Provisional
    smart00027
    Location:238333
    EH; Eps15 homology domain
    cd11995
    Location:11091162
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    PLN02983
    Location:155226
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    pfam16617
    Location:825939
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:10281089
    SH3; Src Homology 3 domain superfamily
  9. XM_006522939.2XP_006523002.1  intersectin-1 isoform X9

    UniProtKB/TrEMBL
    E9Q3I5
    Conserved Domains (8) summary
    PTZ00121
    Location:355739
    PTZ00121; MAEBL; Provisional
    smart00027
    Location:238333
    EH; Eps15 homology domain
    cd11987
    Location:766820
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11991
    Location:10231074
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11995
    Location:11751228
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    PLN02983
    Location:155226
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    pfam16617
    Location:820934
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:10911155
    SH3; Src Homology 3 domain superfamily
  10. XM_006522940.2XP_006523003.1  intersectin-1 isoform X12

    Conserved Domains (5) summary
    PTZ00121
    Location:355739
    PTZ00121; MAEBL; Provisional
    smart00027
    Location:238333
    EH; Eps15 homology domain
    PLN02983
    Location:155226
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    pfam16617
    Location:825931
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:766825
    SH3; Src Homology 3 domain superfamily
  11. XM_036159795.1XP_036015688.1  intersectin-1 isoform X13

    Conserved Domains (5) summary
    PTZ00121
    Location:355739
    PTZ00121; MAEBL; Provisional
    smart00027
    Location:238333
    EH; Eps15 homology domain
    cd11987
    Location:766820
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    pfam16617
    Location:820926
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    NF033761
    Location:117245
    gliding_GltJ; adventurous gliding motility protein GltJ
  12. XM_006522932.5XP_006522995.1  intersectin-1 isoform X2

    Conserved Domains (12) summary
    PTZ00121
    Location:353737
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:16021736
    C2_Intersectin; C2 domain present in Intersectin
    PRK14959
    Location:64206
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    smart00027
    Location:236331
    EH; Eps15 homology domain
    cd11989
    Location:937988
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:10261077
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:10941158
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:11781231
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    cd00160
    Location:12581441
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:823937
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:14601613
    PH_13; Pleckstrin homology domain
    cl17036
    Location:764823
    SH3; Src Homology 3 domain superfamily
  13. XM_006522937.4XP_006523000.1  intersectin-1 isoform X7

    Conserved Domains (10) summary
    PTZ00121
    Location:138522
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:13871521
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:21116
    EH; Eps15 homology domain
    cd11991
    Location:811862
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:879943
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:9631016
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    cd00160
    Location:10431226
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:608722
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:12451398
    PH_13; Pleckstrin homology domain
    cl17036
    Location:549608
    SH3; Src Homology 3 domain superfamily

RNA

  1. XR_004939167.1 RNA Sequence

  2. XR_004939165.1 RNA Sequence

  3. XR_004939168.1 RNA Sequence