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SGTA small glutamine rich tetratricopeptide repeat co-chaperone alpha [ Homo sapiens (human) ]

Gene ID: 6449, updated on 19-Sep-2021

Summary

Official Symbol
SGTAprovided by HGNC
Official Full Name
small glutamine rich tetratricopeptide repeat co-chaperone alphaprovided by HGNC
Primary source
HGNC:HGNC:10819
See related
Ensembl:ENSG00000104969 MIM:603419
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGT; Vpu; SGT1; hSGT; alphaSGT
Summary
This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 22.5), brain (RPKM 21.2) and 25 other tissues See more
Orthologs
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Genomic context

See SGTA in Genome Data Viewer
Location:
19p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (2754714..2783317, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2754713..2783271, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DIRAS family GTPase 1 Neighboring gene solute carrier family 39 member 3 Neighboring gene thimet oligopeptidase 1 Neighboring gene zinc finger protein 554

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 release from cells is inhibited by the overexpression of SGTA PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The enhancement of HIV-1 particle release and Capsid export resulting from the interaction of HIV-1 Vpu with HIV-1 Gag also involves the interaction of both Vpu and Gag with Vpu-binding protein (Ubp; Vpu interactive protein; VIP; SGT; NP_003012) PubMed
Vpu vpu HIV-1 Vpu interacts with SGTA PubMed
vpu Residues 84-210 in SGT and residues 31-35 in HIV-1 Vpu are required for the binding of Vpu to SGT PubMed
vpu Small glutamine-rich tetratricopeptide repeat containing protein, also known as Vpu-binding protein (Ubp) or Vpu interactive protein (VIP), interacts with both HIV-1 Vpu and Gag to play a role in Vpu-mediated enhancement of HIV-1 virion release from cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables BAT3 complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of TRC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extrinsic component of synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
small glutamine-rich tetratricopeptide repeat-containing protein alpha
Names
UBP
alpha-SGT
protein containing three tetratricopeptide repeats
small glutamine rich tetratricopeptide repeat containing alpha
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
viral protein U-binding protein
vpu-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003021.4NP_003012.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha

    See identical proteins and their annotated locations for NP_003012.1

    Status: REVIEWED

    Source sequence(s)
    AL050156
    Consensus CDS
    CCDS12094.1
    UniProtKB/Swiss-Prot
    O43765
    Related
    ENSP00000221566.1, ENST00000221566.7
    Conserved Domains (3) summary
    PLN03088
    Location:105211
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:91119
    TPR; TPR repeat [structural motif]
    pfam16546
    Location:564
    SGTA_dimer; Homodimerization domain of SGTA

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    2754714..2783317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528178.3XP_011526480.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X1

    See identical proteins and their annotated locations for XP_011526480.1

    UniProtKB/Swiss-Prot
    O43765
    Related
    ENSP00000504495.1, ENST00000676943.1
    Conserved Domains (3) summary
    PLN03088
    Location:105211
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:91119
    TPR; TPR repeat [structural motif]
    pfam16546
    Location:564
    SGTA_dimer; Homodimerization domain of SGTA
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