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Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha [ Mus musculus (house mouse) ]

Gene ID: 52551, updated on 13-Oct-2022

Summary

Official Symbol
Sgtaprovided by MGI
Official Full Name
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alphaprovided by MGI
Primary source
MGI:MGI:1098703
See related
Ensembl:ENSMUSG00000004937 AllianceGenome:MGI:1098703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sgt; Stg; D10Ertd190e; 5330427H01Rik
Summary
Predicted to enable several functions, including BAT3 complex binding activity; protein dimerization activity; and protein self-association. Predicted to be involved in several processes, including establishment of protein localization to membrane; regulation of ER-associated ubiquitin-dependent protein catabolic process; and ubiquitin-dependent ERAD pathway. Predicted to be located in cytosol and nucleus. Predicted to be part of TRC complex. Predicted to be active in membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and skin. Orthologous to human SGTA (small glutamine rich tetratricopeptide repeat co-chaperone alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 191.2), mammary gland adult (RPKM 106.5) and 28 other tissues See more
Orthologs
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Genomic context

See Sgta in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80879905..80896105, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81044071..81060271, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DIRAS family, GTP-binding RAS-like 1 Neighboring gene predicted gene 16099 Neighboring gene solute carrier family 39 (zinc transporter), member 3 Neighboring gene thimet oligopeptidase 1 Neighboring gene cAMP responsive element binding protein 3-like 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC6336

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BAT3 complex binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein self-association ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of TRC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
small glutamine-rich tetratricopeptide repeat-containing protein alpha
Names
alpha-SGT
small glutamine-rich tetratricopeptide repeat (TPR) containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358549.1NP_001345478.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK051005, AK079168, BY143324, BY287841, CD775676
    Consensus CDS
    CCDS35990.1
    UniProtKB/Swiss-Prot
    Q99L52
    Conserved Domains (3) summary
    sd00006
    Location:92120
    TPR; TPR repeat [structural motif]
    pfam16546
    Location:564
    SGTA_dimer; Homodimerisation domain of SGTA
    cl26005
    Location:106212
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  2. NM_001358550.1NP_001345479.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC152500, AK051005, BY084509, CD775676
    Consensus CDS
    CCDS88056.1
    UniProtKB/TrEMBL
    A0A8C6I117, Q3TN35
    Related
    ENSMUSP00000151949.2, ENSMUST00000218208.2
    Conserved Domains (3) summary
    PLN03088
    Location:105211
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:91119
    TPR; TPR repeat [structural motif]
    pfam16546
    Location:564
    SGTA_dimer; Homodimerization domain of SGTA
  3. NM_024499.2NP_078775.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 1

    See identical proteins and their annotated locations for NP_078775.1

    Status: VALIDATED

    Source sequence(s)
    AC152500, AK051005, AK079168, BY084509, CD775676
    Consensus CDS
    CCDS35990.1
    UniProtKB/Swiss-Prot
    Q8BJU0, Q99L52
    Related
    ENSMUSP00000005067.6, ENSMUST00000005067.6
    Conserved Domains (3) summary
    sd00006
    Location:92120
    TPR; TPR repeat [structural motif]
    pfam16546
    Location:564
    SGTA_dimer; Homodimerisation domain of SGTA
    cl26005
    Location:106212
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80879905..80896105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513877.2XP_006513940.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X1

    See identical proteins and their annotated locations for XP_006513940.1

    UniProtKB/Swiss-Prot
    Q8BJU0
    UniProtKB/TrEMBL
    A0A8C6I117, Q3TN35
    Conserved Domains (3) summary
    PLN03088
    Location:105211
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:91119
    TPR; TPR repeat [structural motif]
    pfam16546
    Location:564
    SGTA_dimer; Homodimerization domain of SGTA
  2. XM_030245176.2XP_030101036.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X2

    Conserved Domains (2) summary
    PLN03088
    Location:4110
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:2353
    TPR; TPR repeat [structural motif]