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Dhx38 DEAH-box helicase 38 [ Mus musculus (house mouse) ]

Gene ID: 64340, updated on 12-May-2024

Summary

Official Symbol
Dhx38provided by MGI
Official Full Name
DEAH-box helicase 38provided by MGI
Primary source
MGI:MGI:1927617
See related
Ensembl:ENSMUSG00000037993 AllianceGenome:MGI:1927617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ddx38; Prp16; KIAA0224; 5730550P09Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa 84. Orthologous to human DHX38 (DEAH-box helicase 38). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 12.7), CNS E11.5 (RPKM 11.5) and 28 other tissues See more
Orthologs
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Genomic context

See Dhx38 in Genome Data Viewer
Location:
8 D3; 8 57.09 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110274631..110292493, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109547999..109565861, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene polyamine modulated factor 1 binding protein 1 Neighboring gene predicted gene, 35145 Neighboring gene STARR-seq mESC enhancer starr_22655 Neighboring gene predicted gene, 39246 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112089480-112089589 Neighboring gene STARR-positive B cell enhancer ABC_E565 Neighboring gene thioredoxin-like 4B Neighboring gene haptoglobin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 38
DEAH (Asp-Glu-Ala-His) box polypeptide 38
pre-mRNA splicing factor 16
NP_848467.1
XP_006531324.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178380.2NP_848467.1  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

    See identical proteins and their annotated locations for NP_848467.1

    Status: VALIDATED

    Source sequence(s)
    AC125162, AI503007, BC046557
    Consensus CDS
    CCDS22652.1
    UniProtKB/TrEMBL
    Q6A0A1, Q80X98
    Related
    ENSMUSP00000047865.8, ENSMUST00000042601.9
    Conserved Domains (5) summary
    smart00490
    Location:759862
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:527714
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:9311013
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:552688
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:10641147
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RNA

  1. NR_151644.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125162

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110274631..110292493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531261.3XP_006531324.1  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1

    UniProtKB/TrEMBL
    Q6A0A1
    Conserved Domains (1) summary
    COG1643
    Location:5151146
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]