U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NFKBIZ NFKB inhibitor zeta [ Homo sapiens (human) ]

Gene ID: 64332, updated on 23-Nov-2023

Summary

Official Symbol
NFKBIZprovided by HGNC
Official Full Name
NFKB inhibitor zetaprovided by HGNC
Primary source
HGNC:HGNC:29805
See related
Ensembl:ENSG00000144802 MIM:608004; AllianceGenome:HGNC:29805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IKBZ; INAP; MAIL; ikB-zeta; ikappaBzeta; IkappaB-zeta; I-kappa-B-zeta
Summary
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 120.3), urinary bladder (RPKM 31.0) and 18 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NFKBIZ in Genome Data Viewer
Location:
3q12.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (101827990..101861022)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (104540783..104573840)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (101546834..101579866)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20178 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:101444325-101444936 Neighboring gene PDCL3 pseudogene 4 Neighboring gene centrosomal protein 97 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20179 Neighboring gene Sharpr-MPRA regulatory region 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20180 Neighboring gene neurexophilin and PC-esterase domain family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20184 Neighboring gene Sharpr-MPRA regulatory region 1067 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20185 Neighboring gene Sharpr-MPRA regulatory region 7874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20186 Neighboring gene MPRA-validated peak4754 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20187 Neighboring gene RIG-I dependent antiviral response regulator RNA Neighboring gene uncharacterized LOC101929411

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (NFKBIZ) in primary human brain microvascular endothelial cells PubMed
tat HIV-1 Tat upregulates the expression of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (NFKBIZ) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ30225, FLJ34463

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables POU domain binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in B cell receptor apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell mediated immunity IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in T-helper 1 cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in T-helper 17 cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to interleukin-17 IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in chronic inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of skin barrier IEA
Inferred from Electronic Annotation
more info
 
involved_in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 
involved_in homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response to wounding IEA
Inferred from Electronic Annotation
more info
 
involved_in isotype switching IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte activation IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in plasma cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T-helper 17 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cisplatin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to folic acid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in spleen development IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
NF-kappa-B inhibitor zeta
Names
IL-1 inducible nuclear ankyrin-repeat protein
molecule possessing ankyrin repeats induced by lipopolysaccharide
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005474.3NP_001005474.1  NF-kappa-B inhibitor zeta isoform b

    See identical proteins and their annotated locations for NP_001005474.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains alternative 5' non-coding exons compared to variant 1, and initiates translation from an in-frame downstream AUG, resulting in a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    AF548362, AW004900, BC014587, BX492097, DA541852
    Consensus CDS
    CCDS43123.1
    UniProtKB/TrEMBL
    C9JZ23
    Related
    ENSP00000377618.2, ENST00000394054.6
    Conserved Domains (4) summary
    cd00204
    Location:407573
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:348436
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:498556
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:451509
    ANK; ANK repeat [structural motif]
  2. NM_031419.4NP_113607.1  NF-kappa-B inhibitor zeta isoform a

    See identical proteins and their annotated locations for NP_113607.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BC014587, BC060800
    Consensus CDS
    CCDS2946.1
    UniProtKB/Swiss-Prot
    B3KNR2, D3DN54, Q8IUL4, Q8NAZ8, Q9BYH8
    UniProtKB/TrEMBL
    C9JZ23
    Related
    ENSP00000325663.5, ENST00000326172.9
    Conserved Domains (4) summary
    cd00204
    Location:507673
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:448536
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:598656
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:551609
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    101827990..101861022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    104540783..104573840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)