Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfkbizprovided by MGI
Official Full Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zetaprovided by MGI
Primary source: MGI:MGI:1931595
See related: Ensembl:ENSMUSG00000035356 AllianceGenome:MGI:1931595
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: INAP; Mail
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coregulator activity. Involved in several processes, including lymphocyte activation involved in immune response; positive regulation of immune response; and response to bacterium. Acts upstream of or within inflammatory response. Is active in nucleus. Is expressed in central nervous system; early conceptus; eye; and genitourinary system. Used to study Stevens-Johnson syndrome and atopic dermatitis. Orthologous to human NFKBIZ (NFKB inhibitor zeta). [provided by Alliance of Genome Resources, Jun 2025]
Expression: Broad expression in duodenum adult (RPKM 28.5), small intestine adult (RPKM 21.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C1.1; 16 33.65 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (55631740..55659018, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (55811375..55838954, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-kappaB p50-IkappaBzeta pathway.
Title: Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50-IκBζ pathway.
IkappaBzeta regulates the development of nonalcoholic fatty liver disease through the attenuation of hepatic steatosis in mice.
Title: IκBζ regulates the development of nonalcoholic fatty liver disease through the attenuation of hepatic steatosis in mice.
Loss of IkappaBzeta Drives Dentin Formation via Altered H3K4me3 Status.
Title: Loss of IκBζ Drives Dentin Formation via Altered H3K4me3 Status.
Regulation of the Nfkbiz Gene and Its Protein Product IkBzeta in Animal Models of Sepsis and Endotoxic Shock.
Title: Regulation of the Nfkbiz Gene and Its Protein Product IkBζ in Animal Models of Sepsis and Endotoxic Shock.
IkappaBzeta controls NLRP3 inflammasome activation via upregulation of the Nlrp3 gene.
Title: IκBζ controls NLRP3 inflammasome activation via upregulation of the Nlrp3 gene.
Gut Commensal-Induced IkappaBzeta Expression in Dendritic Cells Influences the Th17 Response.
Title: Gut Commensal-Induced IκBζ Expression in Dendritic Cells Influences the Th17 Response.
The negative feedback loop of NF-kappaB/miR-376b/NFKBIZ in septic acute kidney injury.
Title: The negative feedback loop of NF-κB/miR-376b/NFKBIZ in septic acute kidney injury.
Association of a dysbiotic oral microbiota with the development of focal lymphocytic sialadenitis in IkappaB-zeta-deficient mice.
Title: Association of a dysbiotic oral microbiota with the development of focal lymphocytic sialadenitis in IκB-ζ-deficient mice.
Induction of IkappaBzeta Augments Cytokine and Chemokine Production by IL-33 in Mast Cells.
Title: Induction of IκBζ Augments Cytokine and Chemokine Production by IL-33 in Mast Cells.
Keratinocyte-derived IkappaBzeta drives psoriasis and associated systemic inflammation.
Title: Keratinocyte-derived IκBζ drives psoriasis and associated systemic inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables POU domain binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell receptor apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-helper 1 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-helper 17 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adaptive immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cytokine stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to interleukin-17	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-17	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chronic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of skin barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immunoglobulin mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in isotype switching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in keratinocyte activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphocyte activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T-helper 17 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cisplatin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cytokine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to folic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skin development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skin epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spleen development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NF-kappa-B inhibitor zeta

Names: I-kappa-B-zeta; IL-1 inducible nuclear ankyrin-repeat protein; IkappaB-zeta; ikB-zeta; ikappaBzeta; molecule possessing ankyrin-repeats induced by lipopolysaccharide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159394.1 → NP_001152866.1 NF-kappa-B inhibitor zeta isoform a

See identical proteins and their annotated locations for NP_001152866.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AB026551, AK082908

Consensus CDS

CCDS28216.1

UniProtKB/Swiss-Prot

Q3TVL7, Q3TWK9, Q3U8Y9, Q3UCI2, Q3URP0, Q3UW99, Q5NT97, Q99NA4, Q9EST8

Related

ENSMUSP00000110102.2, ENSMUST00000114458.8

Conserved Domains (3) summary

PHA03095
Location:505 → 701

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:561 → 619

ANK; ANK repeat [structural motif]

pfam12796
Location:458 → 546

Ank_2; Ankyrin repeats (3 copies)
NM_001159395.2 → NP_001152867.1 NF-kappa-B inhibitor zeta isoform b

See identical proteins and their annotated locations for NP_001152867.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks the alternate exon that in variant 1 contains the translation start site. This results in a downstream in-frame translation start site being used. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AC156020, AC165151

Consensus CDS

CCDS49869.1

UniProtKB/Swiss-Prot

Q9EST8

Related

ENSMUSP00000110101.2, ENSMUST00000114457.8

Conserved Domains (4) summary

cd00204
Location:418 → 584

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:359 → 447

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:509 → 567

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:462 → 520

ANK; ANK repeat [structural motif]
NM_030612.4 → NP_085115.1 NF-kappa-B inhibitor zeta isoform a

See identical proteins and their annotated locations for NP_085115.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC156020, AC165151

Consensus CDS

CCDS28216.1

UniProtKB/Swiss-Prot

Q3TVL7, Q3TWK9, Q3U8Y9, Q3UCI2, Q3URP0, Q3UW99, Q5NT97, Q99NA4, Q9EST8

Related

ENSMUSP00000041173.7, ENSMUST00000036273.13

Conserved Domains (3) summary

PHA03095
Location:505 → 701

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:561 → 619

ANK; ANK repeat [structural motif]

pfam12796
Location:458 → 546

Ank_2; Ankyrin repeats (3 copies)