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Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta [ Mus musculus (house mouse) ]

Gene ID: 80859, updated on 23-Apr-2024

Summary

Official Symbol
Nfkbizprovided by MGI
Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zetaprovided by MGI
Primary source
MGI:MGI:1931595
See related
Ensembl:ENSMUSG00000035356 AllianceGenome:MGI:1931595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
INAP; Mail
Summary
Involved in T cell receptor signaling pathway and positive regulation of T-helper 17 cell differentiation. Acts upstream of or within inflammatory response. Located in nucleus. Is expressed in early conceptus; eye; and genitourinary system. Used to study Stevens-Johnson syndrome and atopic dermatitis. Orthologous to human NFKBIZ (NFKB inhibitor zeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 28.5), small intestine adult (RPKM 21.5) and 20 other tissues See more
Orthologs
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Genomic context

Location:
16 C1.1; 16 33.65 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (55631740..55659018, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (55811375..55838954, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIG-I dependent antiviral response regulator RNA Neighboring gene STARR-positive B cell enhancer mm9_chr16:55747326-55747626 Neighboring gene cyclin-dependent kinases regulatory subunit 2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr16:55754561-55754862 Neighboring gene STARR-seq mESC enhancer starr_41041 Neighboring gene predicted gene, 26369 Neighboring gene STARR-positive B cell enhancer mm9_chr16:55820985-55821286 Neighboring gene STARR-positive B cell enhancer mm9_chr16:55822089-55822389 Neighboring gene STARR-positive B cell enhancer ABC_E7463 Neighboring gene STARR-positive B cell enhancer ABC_E10911 Neighboring gene neurexophilin and PC-esterase domain family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1926 Neighboring gene adaptor-related protein complex 3, sigma 1 subunit pseudogene Neighboring gene conserved helix-loop-helix ubiquitous kinase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables POU domain binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in B cell receptor apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T-helper 1 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T-helper 17 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adaptive immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to interleukin-17 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to interleukin-17 IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to organic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chronic inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in isotype switching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in keratinocyte activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymphocyte activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T-helper 17 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cisplatin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cytokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to folic acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to organic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skin epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NF-kappa-B inhibitor zeta
Names
I-kappa-B-zeta
IL-1 inducible nuclear ankyrin-repeat protein
IkappaB-zeta
ikB-zeta
ikappaBzeta
molecule possessing ankyrin-repeats induced by lipopolysaccharide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159394.1NP_001152866.1  NF-kappa-B inhibitor zeta isoform a

    See identical proteins and their annotated locations for NP_001152866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AB026551, AK082908
    Consensus CDS
    CCDS28216.1
    UniProtKB/Swiss-Prot
    Q3TVL7, Q3TWK9, Q3U8Y9, Q3UCI2, Q3URP0, Q3UW99, Q5NT97, Q99NA4, Q9EST8
    Related
    ENSMUSP00000110102.2, ENSMUST00000114458.8
    Conserved Domains (3) summary
    PHA03095
    Location:505701
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:561619
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:458546
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_001159395.2NP_001152867.1  NF-kappa-B inhibitor zeta isoform b

    See identical proteins and their annotated locations for NP_001152867.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks the alternate exon that in variant 1 contains the translation start site. This results in a downstream in-frame translation start site being used. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC156020, AC165151
    Consensus CDS
    CCDS49869.1
    UniProtKB/Swiss-Prot
    Q9EST8
    Related
    ENSMUSP00000110101.2, ENSMUST00000114457.8
    Conserved Domains (4) summary
    cd00204
    Location:418584
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:359447
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:509567
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:462520
    ANK; ANK repeat [structural motif]
  3. NM_030612.4NP_085115.1  NF-kappa-B inhibitor zeta isoform a

    See identical proteins and their annotated locations for NP_085115.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC156020, AC165151
    Consensus CDS
    CCDS28216.1
    UniProtKB/Swiss-Prot
    Q3TVL7, Q3TWK9, Q3U8Y9, Q3UCI2, Q3URP0, Q3UW99, Q5NT97, Q99NA4, Q9EST8
    Related
    ENSMUSP00000041173.7, ENSMUST00000036273.13
    Conserved Domains (3) summary
    PHA03095
    Location:505701
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:561619
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:458546
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    55631740..55659018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)