Format

Send to:

Choose Destination

XPO4 exportin 4 [ Homo sapiens (human) ]

Gene ID: 64328, updated on 9-Feb-2020

Summary

Official Symbol
XPO4provided by HGNC
Official Full Name
exportin 4provided by HGNC
Primary source
HGNC:HGNC:17796
See related
Ensembl:ENSG00000132953 MIM:611449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
exp4
Summary
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]
Expression
Ubiquitous expression in thyroid (RPKM 3.0), heart (RPKM 2.8) and 25 other tissues See more
Orthologs

Genomic context

See XPO4 in Genome Data Viewer
Location:
13q12.11
Exon count:
29
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (20777329..20902774, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21351468..21476913, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene interleukin 17D Neighboring gene EEF1A lysine methyltransferase 1 Neighboring gene RAN pseudogene 8 Neighboring gene CCR4-NOT transcription complex subunit 4 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 367 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with exportin 4 (XPO4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13046, KIAA1721

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372061.1NP_001358990.1  exportin-4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356285, AL512652
  2. NM_022459.4NP_071904.4  exportin-4 isoform 1

    See identical proteins and their annotated locations for NP_071904.4

    Status: VALIDATED

    Source sequence(s)
    AB051508, AL512652, BQ184183, DA119417
    Consensus CDS
    CCDS41872.1
    UniProtKB/Swiss-Prot
    Q9C0E2
    Related
    ENSP00000255305.6, ENST00000255305.10

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    20777329..20902774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266502.1XP_005266559.1  exportin-4 isoform X1

    See identical proteins and their annotated locations for XP_005266559.1

  2. XM_024449395.1XP_024305163.1  exportin-4 isoform X4

  3. XM_011535197.1XP_011533499.1  exportin-4 isoform X1

    See identical proteins and their annotated locations for XP_011533499.1

  4. XM_011535198.1XP_011533500.1  exportin-4 isoform X4

    See identical proteins and their annotated locations for XP_011533500.1

  5. XM_024449394.1XP_024305162.1  exportin-4 isoform X1

  6. XM_011535200.2XP_011533502.1  exportin-4 isoform X4

    See identical proteins and their annotated locations for XP_011533502.1

  7. XM_017020705.1XP_016876194.1  exportin-4 isoform X4

  8. XM_017020704.2XP_016876193.1  exportin-4 isoform X3

  9. XM_005266504.4XP_005266561.1  exportin-4 isoform X6

  10. XM_017020706.2XP_016876195.1  exportin-4 isoform X5

RNA

  1. XR_001749637.1 RNA Sequence

Support Center