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XPO4 exportin 4 [ Homo sapiens (human) ]

Gene ID: 64328, updated on 23-Nov-2023

Summary

Official Symbol
XPO4provided by HGNC
Official Full Name
exportin 4provided by HGNC
Primary source
HGNC:HGNC:17796
See related
Ensembl:ENSG00000132953 MIM:611449; AllianceGenome:HGNC:17796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
exp4
Summary
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]
Expression
Ubiquitous expression in thyroid (RPKM 3.0), heart (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See XPO4 in Genome Data Viewer
Location:
13q12.11
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (20777329..20902774, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (19970477..20095920, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21351468..21476913, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5157 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:21290864-21291578 Neighboring gene Sharpr-MPRA regulatory region 1468 Neighboring gene interleukin 17D Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21303728-21304255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21304256-21304782 Neighboring gene EEF1A lysine methyltransferase 1 Neighboring gene RAN pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7426 Neighboring gene uncharacterized LOC124903129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5158 Neighboring gene CCR4-NOT transcription complex subunit 4 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:21513739-21514238 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:21517633-21518209 Neighboring gene long intergenic non-protein coding RNA 367 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with exportin 4 (XPO4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ13046, KIAA1721

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear export signal receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372061.1NP_001358990.1  exportin-4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356285, AL512652
    UniProtKB/TrEMBL
    Q8IVQ8
  2. NM_022459.5NP_071904.4  exportin-4 isoform 1

    See identical proteins and their annotated locations for NP_071904.4

    Status: VALIDATED

    Source sequence(s)
    AL356285, AL512652
    Consensus CDS
    CCDS41872.1
    UniProtKB/Swiss-Prot
    Q5VUZ5, Q8N3V6, Q9C0E2, Q9H934
    UniProtKB/TrEMBL
    Q8IVQ8
    Related
    ENSP00000255305.6, ENST00000255305.11

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    20777329..20902774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430537.1XP_047286493.1  exportin-4 isoform X1

    UniProtKB/TrEMBL
    Q0VG75, Q8IVQ8
  2. XM_024449394.2XP_024305162.1  exportin-4 isoform X4

    UniProtKB/TrEMBL
    Q8IVQ8
  3. XM_047430539.1XP_047286495.1  exportin-4 isoform X3

    UniProtKB/TrEMBL
    Q8IVQ8
  4. XM_047430538.1XP_047286494.1  exportin-4 isoform X3

    UniProtKB/TrEMBL
    Q8IVQ8
  5. XM_011535200.3XP_011533502.1  exportin-4 isoform X3

    See identical proteins and their annotated locations for XP_011533502.1

    UniProtKB/TrEMBL
    Q8IVQ8
  6. XM_047430540.1XP_047286496.1  exportin-4 isoform X3

    UniProtKB/TrEMBL
    Q8IVQ8
  7. XM_017020705.2XP_016876194.1  exportin-4 isoform X3

    UniProtKB/TrEMBL
    Q8IVQ8
  8. XM_017020704.3XP_016876193.1  exportin-4 isoform X2

    UniProtKB/TrEMBL
    Q8IVQ8
  9. XM_005266504.5XP_005266561.1  exportin-4 isoform X6

    UniProtKB/TrEMBL
    Q8IVQ8
  10. XM_017020706.3XP_016876195.1  exportin-4 isoform X5

    UniProtKB/TrEMBL
    Q8IVQ8
  11. XM_047430541.1XP_047286497.1  exportin-4 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    19970477..20095920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374849.1XP_054230824.1  exportin-4 isoform X1

    UniProtKB/TrEMBL
    Q0VG75, Q8IVQ8
  2. XM_054374856.1XP_054230831.1  exportin-4 isoform X4

    UniProtKB/TrEMBL
    Q8IVQ8
  3. XM_054374854.1XP_054230829.1  exportin-4 isoform X3

    UniProtKB/TrEMBL
    Q8IVQ8
  4. XM_054374852.1XP_054230827.1  exportin-4 isoform X3

    UniProtKB/TrEMBL
    Q8IVQ8
  5. XM_054374851.1XP_054230826.1  exportin-4 isoform X3

    UniProtKB/TrEMBL
    Q8IVQ8
  6. XM_054374855.1XP_054230830.1  exportin-4 isoform X3

    UniProtKB/TrEMBL
    Q8IVQ8
  7. XM_054374853.1XP_054230828.1  exportin-4 isoform X3

    UniProtKB/TrEMBL
    Q8IVQ8
  8. XM_054374850.1XP_054230825.1  exportin-4 isoform X2

    UniProtKB/TrEMBL
    Q8IVQ8
  9. XM_054374858.1XP_054230833.1  exportin-4 isoform X6

    UniProtKB/TrEMBL
    Q8IVQ8
  10. XM_054374857.1XP_054230832.1  exportin-4 isoform X5

    UniProtKB/TrEMBL
    Q8IVQ8
  11. XM_054374859.1XP_054230834.1  exportin-4 isoform X7