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SRSF5 serine and arginine rich splicing factor 5 [ Homo sapiens (human) ]

Gene ID: 6430, updated on 5-Sep-2021

Summary

Official Symbol
SRSF5provided by HGNC
Official Full Name
serine and arginine rich splicing factor 5provided by HGNC
Primary source
HGNC:HGNC:10787
See related
Ensembl:ENSG00000100650 MIM:600914
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRS; SFRS5; SRP40
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 175.0), skin (RPKM 153.9) and 25 other tissues See more
Orthologs
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Genomic context

See SRSF5 in Genome Data Viewer
Location:
14q24.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (69767112..69772005)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (70233859..70238722)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 177 Neighboring gene sushi domain containing 6 Neighboring gene Sharpr-MPRA regulatory region 8327 Neighboring gene uncharacterized LOC100289511 Neighboring gene solute carrier family 10 member 1 Neighboring gene Sharpr-MPRA regulatory region 10266 Neighboring gene uncharacterized LOC100506358

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env The bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates HIV-1 rev, env, vpu, and nef gene expression PubMed
Nef nef The bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates HIV-1 rev, env, vpu, and nef gene expression PubMed
Pr55(Gag) gag Human CRM1 and SRp40 increase the amount of unspliced HIV-1 RNA and have a more-than-additive effect on HIV-1 titers in mouse cells PubMed
gag SR proteins, particularly SRp40 and SRp55, increase HIV-1 Gag translation from unspliced viral RNA. The second RNA recognition motif and the arginine-serine (RS) domain are determinants of SR protein activity PubMed
Rev rev SF2/ASF and SRp40 interact with a purine-rich motif within the HIV-1 exon 5, and this interaction activates splicing at an upstream 3' splice site and binding of the 5' splice site to U1 snRNP, which are required for splicing of HIV-1 rev and nef mRNAs PubMed
Vpu vpu The bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates HIV-1 rev, env, vpu, and nef gene expression PubMed
capsid gag Human CRM1 and SRp40 have a more-than-additive effect on HIV-1 CA production in mouse cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase B binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing TAS
Traceable Author Statement
more info
PubMed 
involved_in mRNA splice site selection TAS
Traceable Author Statement
more info
PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
serine/arginine-rich splicing factor 5
Names
SR splicing factor 5
delayed-early protein HRS
pre-mRNA-splicing factor SRP40
splicing factor, arginine/serine-rich 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039465.2NP_001034554.1  serine/arginine-rich splicing factor 5

    See identical proteins and their annotated locations for NP_001034554.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA640719, BC018823, BU928782
    Consensus CDS
    CCDS32109.1
    UniProtKB/Swiss-Prot
    Q13243
    UniProtKB/TrEMBL
    A0A024R6D8
    Related
    ENSP00000377892.2, ENST00000394366.6
    Conserved Domains (2) summary
    cd12595
    Location:574
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
  2. NM_001320214.2NP_001307143.1  serine/arginine-rich splicing factor 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL157789, BC040209, DC307911
    Consensus CDS
    CCDS32109.1
    UniProtKB/Swiss-Prot
    Q13243
    UniProtKB/TrEMBL
    A0A024R6D8
    Related
    ENSP00000451088.1, ENST00000557154.6
    Conserved Domains (2) summary
    cd12595
    Location:574
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
  3. NM_006925.5NP_008856.2  serine/arginine-rich splicing factor 5

    See identical proteins and their annotated locations for NP_008856.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL157789, BX407495, DR761538
    Consensus CDS
    CCDS32109.1
    UniProtKB/Swiss-Prot
    Q13243
    UniProtKB/TrEMBL
    A0A024R6D8
    Related
    ENSP00000451391.1, ENST00000553635.5
    Conserved Domains (2) summary
    cd12595
    Location:574
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    69767112..69772005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267999.2XP_005268056.1  serine/arginine-rich splicing factor 5 isoform X1

    See identical proteins and their annotated locations for XP_005268056.1

    Conserved Domains (2) summary
    cd12595
    Location:574
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
  2. XM_011537077.3XP_011535379.1  serine/arginine-rich splicing factor 5 isoform X2

    See identical proteins and their annotated locations for XP_011535379.1

    Conserved Domains (2) summary
    cd12337
    Location:566
    RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    cd12600
    Location:75145
    RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
  3. XM_005268000.2XP_005268057.1  serine/arginine-rich splicing factor 5 isoform X1

    See identical proteins and their annotated locations for XP_005268057.1

    Conserved Domains (2) summary
    cd12595
    Location:574
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
  4. XM_017021593.2XP_016877082.1  serine/arginine-rich splicing factor 5 isoform X1

    Related
    ENST00000556587.5
    Conserved Domains (2) summary
    cd12595
    Location:574
    RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    cd12765
    Location:99179
    RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
  5. XM_017021594.2XP_016877083.1  serine/arginine-rich splicing factor 5 isoform X3

    UniProtKB/TrEMBL
    Q86U32
    Conserved Domains (1) summary
    cl17169
    Location:151
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_943505.2 RNA Sequence

    Related
    ENST00000555547.5
  2. XR_001750510.2 RNA Sequence

  3. XR_001750508.2 RNA Sequence

  4. XR_001750513.2 RNA Sequence

  5. XR_943506.2 RNA Sequence

  6. XR_001750514.2 RNA Sequence

  7. XR_001750509.1 RNA Sequence

  8. XR_001750512.1 RNA Sequence

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