Format

Send to:

Choose Destination

PDLIM2 PDZ and LIM domain 2 [ Homo sapiens (human) ]

Gene ID: 64236, updated on 12-Jan-2019

Summary

Official Symbol
PDLIM2provided by HGNC
Official Full Name
PDZ and LIM domain 2provided by HGNC
Primary source
HGNC:HGNC:13992
See related
Ensembl:ENSG00000120913 MIM:609722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLIM; MYSTIQUE
Summary
This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Expression
Broad expression in spleen (RPKM 22.4), lung (RPKM 9.5) and 21 other tissues See more
Orthologs

Genomic context

See PDLIM2 in Genome Data Viewer
Location:
8p21.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (22578741..22598025)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22435805..22455538)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 3 catalytic subunit gamma Neighboring gene BTF3 pseudogene 3 Neighboring gene sorbin and SH3 domain containing 3 Neighboring gene proline-rich proteoglycan 2-like Neighboring gene chromosome 8 open reading frame 58 Neighboring gene cell cycle and apoptosis regulator 2 Neighboring gene bridging integrator 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34715

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PDZ and LIM domain protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030435.2 RefSeqGene

    Range
    5001..20558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001368120.1NP_001355049.1  PDZ and LIM domain protein 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC037459
  2. NM_021630.6NP_067643.3  PDZ and LIM domain protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC037459
    Consensus CDS
    CCDS6032.2
    UniProtKB/Swiss-Prot
    Q96JY6
    Related
    ENSP00000312634.7, ENST00000308354.11
    Conserved Domains (3) summary
    cd09449
    Location:536588
    LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
    cd00992
    Location:259330
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:462505
    DUF4749; Domain of unknown function (DUF4749)
  3. NM_176871.4NP_789847.1  PDZ and LIM domain protein 2 isoform 1

    See identical proteins and their annotated locations for NP_789847.1

    Status: REVIEWED

    Source sequence(s)
    AC037459
    Consensus CDS
    CCDS34860.1
    UniProtKB/Swiss-Prot
    Q96JY6
    Related
    ENSP00000265810.4, ENST00000265810.8
    Conserved Domains (3) summary
    cd09449
    Location:286342
    LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
    cd00992
    Location:980
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:212255
    DUF4749; Domain of unknown function (DUF4749)
  4. NM_198042.4NP_932159.1  PDZ and LIM domain protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC037459
    Consensus CDS
    CCDS34861.1
    UniProtKB/Swiss-Prot
    Q96JY6
    Related
    ENSP00000386868.1, ENST00000409141.5
    Conserved Domains (2) summary
    cd00992
    Location:980
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:212257
    DUF4749; Domain of unknown function (DUF4749)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    22578741..22598025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center