U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

C8orf58 chromosome 8 open reading frame 58 [ Homo sapiens (human) ]

Gene ID: 541565, updated on 1-Mar-2024

Summary

Official Symbol
C8orf58provided by HGNC
Official Full Name
chromosome 8 open reading frame 58provided by HGNC
Primary source
HGNC:HGNC:32233
See related
Ensembl:ENSG00000241852 AllianceGenome:HGNC:32233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 9.0), placenta (RPKM 8.5) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See C8orf58 in Genome Data Viewer
Location:
8p21.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22599599..22604142)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22873482..22878025)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22457112..22461655)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22406579-22407079 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22408405-22409369 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22409593-22410470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22410471-22411346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22413914-22414436 Neighboring gene sorbin and SH3 domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18990 Neighboring gene Sharpr-MPRA regulatory region 12029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22421349-22422242 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22429393-22430084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22430085-22430775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22431841-22432559 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22435755-22436448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22439222-22439914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22442189-22442858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22447071-22448071 Neighboring gene PDZ and LIM domain 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22454615-22455362 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22455363-22456110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22458799-22459676 Neighboring gene uncharacterized LOC107986876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27082 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22462104-22462604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19003 Neighboring gene cell cycle and apoptosis regulator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22483969-22484602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22485870-22486503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22486504-22487136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22488646-22489180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22489181-22489715 Neighboring gene bridging integrator 3 Neighboring gene BIN3 intronic transcript 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
uncharacterized protein C8orf58

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013842.3NP_001013864.1  uncharacterized protein C8orf58 isoform 1

    See identical proteins and their annotated locations for NP_001013864.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC037459, AI380311, DC328974
    Consensus CDS
    CCDS34862.1
    UniProtKB/Swiss-Prot
    B4DI44, Q8NAV2
    Related
    ENSP00000289989.5, ENST00000289989.10
    Conserved Domains (1) summary
    pfam15552
    Location:73364
    DUF4657; Domain of unknown function (DUF4657)
  2. NM_001198827.2NP_001185756.1  uncharacterized protein C8orf58 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC037459, AI380311, DC328974
    Consensus CDS
    CCDS75708.1
    UniProtKB/TrEMBL
    A0A087WX44, H7C1D1
    Related
    ENSP00000480712.1, ENST00000614574.4
    Conserved Domains (1) summary
    pfam15552
    Location:73293
    DUF4657; Domain of unknown function (DUF4657)
  3. NM_173686.3NP_775957.2  uncharacterized protein C8orf58 isoform 2

    See identical proteins and their annotated locations for NP_775957.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC037459, AI380311, AK092034, AK295405
    Consensus CDS
    CCDS56527.1
    UniProtKB/Swiss-Prot
    Q8NAV2
    Related
    ENSP00000386265.3, ENST00000409586.7
    Conserved Domains (1) summary
    pfam15552
    Location:73356
    DUF4657; Domain of unknown function (DUF4657)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    22599599..22604142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    22873482..22878025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)