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C8orf58 chromosome 8 open reading frame 58 [ Homo sapiens (human) ]

Gene ID: 541565, updated on 25-Jan-2022

Summary

Official Symbol
C8orf58provided by HGNC
Official Full Name
chromosome 8 open reading frame 58provided by HGNC
Primary source
HGNC:HGNC:32233
See related
Ensembl:ENSG00000241852 AllianceGenome:HGNC:32233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 9.0), placenta (RPKM 8.5) and 23 other tissues See more
Orthologs
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Genomic context

See C8orf58 in Genome Data Viewer
Location:
8p21.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (22599599..22604142)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22457112..22461655)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene sorbin and SH3 domain containing 3 Neighboring gene PDZ and LIM domain 2 Neighboring gene uncharacterized LOC107986876 Neighboring gene cell cycle and apoptosis regulator 2 Neighboring gene bridging integrator 3 Neighboring gene BIN3 intronic transcript 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PDLIM2

Homology

Clone Names

  • FLJ34715

General protein information

Preferred Names
uncharacterized protein C8orf58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013842.3NP_001013864.1  uncharacterized protein C8orf58 isoform 1

    See identical proteins and their annotated locations for NP_001013864.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC037459, AI380311, DC328974
    Consensus CDS
    CCDS34862.1
    UniProtKB/Swiss-Prot
    Q8NAV2
    Related
    ENSP00000289989.5, ENST00000289989.10
    Conserved Domains (1) summary
    pfam15552
    Location:73364
    DUF4657; Domain of unknown function (DUF4657)
  2. NM_001198827.2NP_001185756.1  uncharacterized protein C8orf58 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC037459, AI380311, DC328974
    Consensus CDS
    CCDS75708.1
    UniProtKB/TrEMBL
    A0A087WX44
    Related
    ENSP00000480712.1, ENST00000614574.4
    Conserved Domains (1) summary
    pfam15552
    Location:73293
    DUF4657; Domain of unknown function (DUF4657)
  3. NM_173686.3NP_775957.2  uncharacterized protein C8orf58 isoform 2

    See identical proteins and their annotated locations for NP_775957.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC037459, AI380311, AK092034, AK295405
    Consensus CDS
    CCDS56527.1
    UniProtKB/Swiss-Prot
    Q8NAV2
    Related
    ENSP00000386265.3, ENST00000409586.7
    Conserved Domains (1) summary
    pfam15552
    Location:73356
    DUF4657; Domain of unknown function (DUF4657)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    22599599..22604142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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