U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pdlim2 PDZ and LIM domain 2 [ Mus musculus (house mouse) ]

Gene ID: 213019, updated on 4-May-2024

Summary

Official Symbol
Pdlim2provided by MGI
Official Full Name
PDZ and LIM domain 2provided by MGI
Primary source
MGI:MGI:2384850
See related
Ensembl:ENSMUSG00000022090 AllianceGenome:MGI:2384850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Slim; 4732462F18Rik
Summary
Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in actin cytoskeleton organization; heart development; and muscle structure development. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of filamentous actin. Predicted to be active in Z disc; adherens junction; and stress fiber. Predicted to colocalize with cortical actin cytoskeleton. Orthologous to human PDLIM2 (PDZ and LIM domain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 101.4), small intestine adult (RPKM 50.1) and 16 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pdlim2 in Genome Data Viewer
Location:
14 D2; 14 36.26 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70401667..70415140, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70162621..70177672, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9930012K11 gene Neighboring gene cell cycle activator and apoptosis regulator 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70553578-70553761 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70559515-70559758 Neighboring gene STARR-positive B cell enhancer ABC_E7331 Neighboring gene sorbin and SH3 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E10833 Neighboring gene predicted gene, 26908 Neighboring gene protein phosphatase 3, catalytic subunit, gamma isoform Neighboring gene predicted gene, 33790

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC37634

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables filamin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables muscle alpha-actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables muscle alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables myosin heavy chain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in muscle structure development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of filamentous actin IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
PDZ and LIM domain protein 2
Names
PDZ-LIM protein mystique
STAT-interacting LIM protein
mystique

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253736.1NP_001240665.1  PDZ and LIM domain protein 2

    See identical proteins and their annotated locations for NP_001240665.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC151836, BE634101, BY072232, DV646822
    Consensus CDS
    CCDS27248.1
    UniProtKB/Swiss-Prot
    Q8R1G6
    Related
    ENSMUSP00000116200.2, ENSMUST00000153735.8
    Conserved Domains (3) summary
    cd09449
    Location:283335
    LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
    cd00992
    Location:980
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:198252
    DUF4749; Domain of unknown function (DUF4749)
  2. NM_145978.2NP_666090.1  PDZ and LIM domain protein 2

    See identical proteins and their annotated locations for NP_666090.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AC151836
    Consensus CDS
    CCDS27248.1
    UniProtKB/Swiss-Prot
    Q8R1G6
    Related
    ENSMUSP00000022681.5, ENSMUST00000022681.11
    Conserved Domains (3) summary
    cd09449
    Location:283335
    LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
    cd00992
    Location:980
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:198252
    DUF4749; Domain of unknown function (DUF4749)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70401667..70415140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247711.2XP_030103571.1  PDZ and LIM domain protein 2 isoform X3

    Conserved Domains (3) summary
    cd09449
    Location:246298
    LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
    cd00992
    Location:980
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:153215
    DUF4749; Domain of unknown function (DUF4749)
  2. XM_030247710.2XP_030103570.1  PDZ and LIM domain protein 2 isoform X2

    Conserved Domains (3) summary
    cd09449
    Location:282334
    LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
    cd00992
    Location:980
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:190251
    DUF4749; Domain of unknown function (DUF4749)
  3. XM_036158534.1XP_036014427.1  PDZ and LIM domain protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8R1G6
    Conserved Domains (3) summary
    cd09449
    Location:283335
    LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
    cd00992
    Location:980
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:198252
    DUF4749; Domain of unknown function (DUF4749)
  4. XM_006518783.5XP_006518846.1  PDZ and LIM domain protein 2 isoform X4

    Conserved Domains (2) summary
    cd09449
    Location:224276
    LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
    pfam15936
    Location:141193
    DUF4749; Domain of unknown function (DUF4749)