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MLST8 MTOR associated protein, LST8 homolog [ Homo sapiens (human) ]

Gene ID: 64223, updated on 5-Aug-2022

Summary

Official Symbol
MLST8provided by HGNC
Official Full Name
MTOR associated protein, LST8 homologprovided by HGNC
Primary source
HGNC:HGNC:24825
See related
Ensembl:ENSG00000167965 MIM:612190; AllianceGenome:HGNC:24825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GBL; LST8; POP3; WAT1; GbetaL
Summary
Enables protein serine/threonine kinase activator activity. Involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 10.4), brain (RPKM 8.7) and 25 other tissues See more
Orthologs
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Genomic context

See MLST8 in Genome Data Viewer
Location:
16p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2205454..2209453)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2227913..2231910)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2255455..2259454)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 60 Neighboring gene small nucleolar RNA host gene 19 Neighboring gene TNF receptor associated factor 7 Neighboring gene CASK interacting protein 1 Neighboring gene Sharpr-MPRA regulatory region 11897 Neighboring gene Sharpr-MPRA regulatory region 5944 Neighboring gene BRICHOS domain containing 5 Neighboring gene phosphoglycolate phosphatase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111011

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to DNA damage stimulus IC
Inferred by Curator
more info
PubMed 
involved_in cellular response to hypoxia IC
Inferred by Curator
more info
PubMed 
involved_in cellular response to nutrient levels IC
Inferred by Curator
more info
PubMed 
involved_in cellular response to osmotic stress IC
Inferred by Curator
more info
PubMed 
involved_in cytoskeleton organization IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of apoptotic process IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of autophagy IC
Inferred by Curator
more info
PubMed 
involved_in phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell growth IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of glycolytic process IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of lipid biosynthetic process IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of pentose-phosphate shunt IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of TORC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of TORC1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of TORC2 complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
target of rapamycin complex subunit LST8
Names
TORC subunit LST8
gable
mammalian lethal with SEC13 protein 8
protein GbetaL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199173.3NP_001186102.1  target of rapamycin complex subunit LST8 isoform a

    See identical proteins and their annotated locations for NP_001186102.1

    Status: VALIDATED

    Source sequence(s)
    AC009065, AK021536, AK098762
    Consensus CDS
    CCDS10462.2
    UniProtKB/Swiss-Prot
    Q9BVC4, Q9UJV6
    Related
    ENSP00000457870.1, ENST00000564088.5
    Conserved Domains (2) summary
    cd00200
    Location:14297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4783
    7WD40; WD40 repeat [structural motif]
  2. NM_001199174.3NP_001186103.1  target of rapamycin complex subunit LST8 isoform a

    See identical proteins and their annotated locations for NP_001186103.1

    Status: VALIDATED

    Source sequence(s)
    AC009065
    Consensus CDS
    CCDS10462.2
    UniProtKB/Swiss-Prot
    Q9BVC4, Q9UJV6
    Related
    ENSP00000380313.1, ENST00000397124.5
    Conserved Domains (2) summary
    cd00200
    Location:14297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4783
    7WD40; WD40 repeat [structural motif]
  3. NM_001199175.3NP_001186104.1  target of rapamycin complex subunit LST8 isoform b

    See identical proteins and their annotated locations for NP_001186104.1

    Status: VALIDATED

    Source sequence(s)
    AC009065, AK021536, AK098762, BC088354
    Consensus CDS
    CCDS58409.1
    UniProtKB/Swiss-Prot
    Q9BVC4
    Related
    ENSP00000371888.4, ENST00000382450.8
    Conserved Domains (3) summary
    COG2319
    Location:10319
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:14296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4682
    7WD40; WD40 repeat [structural motif]
  4. NM_001352057.2NP_001338986.1  target of rapamycin complex subunit LST8 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC009065
    Related
    ENSP00000456944.1, ENST00000562352.5
    Conserved Domains (2) summary
    cd00200
    Location:14303
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4789
    7WD40; WD40 repeat [structural motif]
  5. NM_001352059.2NP_001338988.1  target of rapamycin complex subunit LST8 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC009065
    Conserved Domains (2) summary
    sd00039
    Location:2361
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5231
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. NM_001352060.2NP_001338989.1  target of rapamycin complex subunit LST8 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC009065, AY223837
    Related
    ENST00000568542.5
    Conserved Domains (2) summary
    sd00039
    Location:2361
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5231
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. NM_022372.6NP_071767.3  target of rapamycin complex subunit LST8 isoform a

    See identical proteins and their annotated locations for NP_071767.3

    Status: VALIDATED

    Source sequence(s)
    AC009065, BC001313
    Consensus CDS
    CCDS10462.2
    UniProtKB/Swiss-Prot
    Q9BVC4, Q9UJV6
    Related
    ENSP00000456405.1, ENST00000569417.6
    Conserved Domains (2) summary
    cd00200
    Location:14297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4783
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_147904.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009065
  2. NR_147905.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009065
  3. NR_147906.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009065
    Related
    ENST00000301724.14
  4. NR_147907.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009065, AK022227
    Related
    ENST00000566835.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    2205454..2209453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255475.4XP_005255532.3  target of rapamycin complex subunit LST8 isoform X1

  2. XM_047434466.1XP_047290422.1  target of rapamycin complex subunit LST8 isoform X2

  3. XM_005255479.3XP_005255536.1  target of rapamycin complex subunit LST8 isoform X3

    See identical proteins and their annotated locations for XP_005255536.1

    Conserved Domains (2) summary
    cd00200
    Location:14303
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4789
    7WD40; WD40 repeat [structural motif]
  4. XM_047434467.1XP_047290423.1  target of rapamycin complex subunit LST8 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    2227913..2231910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)