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MLST8 MTOR associated protein, LST8 homolog [ Homo sapiens (human) ]

Gene ID: 64223, updated on 24-Nov-2020

Summary

Official Symbol
MLST8provided by HGNC
Official Full Name
MTOR associated protein, LST8 homologprovided by HGNC
Primary source
HGNC:HGNC:24825
See related
Ensembl:ENSG00000167965 MIM:612190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GBL; LST8; POP3; WAT1; GbetaL
Expression
Ubiquitous expression in testis (RPKM 10.4), brain (RPKM 8.7) and 25 other tissues See more
Orthologs

Genomic context

See MLST8 in Genome Data Viewer
Location:
16p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2204628..2209453)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2255178..2259418)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 60 Neighboring gene small nucleolar RNA host gene 19 Neighboring gene TNF receptor associated factor 7 Neighboring gene CASK interacting protein 1 Neighboring gene Sharpr-MPRA regulatory region 11897 Neighboring gene Sharpr-MPRA regulatory region 5944 Neighboring gene BRICHOS domain containing 5 Neighboring gene phosphoglycolate phosphatase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111011

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase B activity TAS
Traceable Author Statement
more info
 
cell cycle arrest TAS
Traceable Author Statement
more info
 
positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of macroautophagy TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TORC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TORC2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
target of rapamycin complex subunit LST8
Names
TORC subunit LST8
gable
mammalian lethal with SEC13 protein 8
protein GbetaL

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199173.3NP_001186102.1  target of rapamycin complex subunit LST8 isoform a

    See identical proteins and their annotated locations for NP_001186102.1

    Status: VALIDATED

    Source sequence(s)
    AC009065, AK021536, AK098762
    Consensus CDS
    CCDS10462.2
    UniProtKB/Swiss-Prot
    Q9BVC4
    Related
    ENSP00000457870.1, ENST00000564088.5
    Conserved Domains (2) summary
    cd00200
    Location:14297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4783
    7WD40; WD40 repeat [structural motif]
  2. NM_001199174.3NP_001186103.1  target of rapamycin complex subunit LST8 isoform a

    See identical proteins and their annotated locations for NP_001186103.1

    Status: VALIDATED

    Source sequence(s)
    AC009065
    Consensus CDS
    CCDS10462.2
    UniProtKB/Swiss-Prot
    Q9BVC4
    Related
    ENSP00000380313.1, ENST00000397124.5
    Conserved Domains (2) summary
    cd00200
    Location:14297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4783
    7WD40; WD40 repeat [structural motif]
  3. NM_001199175.3NP_001186104.1  target of rapamycin complex subunit LST8 isoform b

    See identical proteins and their annotated locations for NP_001186104.1

    Status: VALIDATED

    Source sequence(s)
    AC009065, AK021536, AK098762, BC088354
    Consensus CDS
    CCDS58409.1
    UniProtKB/Swiss-Prot
    Q9BVC4
    Related
    ENSP00000371888.4, ENST00000382450.8
    Conserved Domains (3) summary
    COG2319
    Location:10319
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:14296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4682
    7WD40; WD40 repeat [structural motif]
  4. NM_001352057.2NP_001338986.1  target of rapamycin complex subunit LST8 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC009065
    Related
    ENSP00000456944.1, ENST00000562352.5
    Conserved Domains (2) summary
    cd00200
    Location:14303
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4789
    7WD40; WD40 repeat [structural motif]
  5. NM_001352059.2NP_001338988.1  target of rapamycin complex subunit LST8 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC009065
    Conserved Domains (2) summary
    sd00039
    Location:2361
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5231
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. NM_001352060.2NP_001338989.1  target of rapamycin complex subunit LST8 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC009065, AY223837
    Related
    ENST00000568542.5
    Conserved Domains (2) summary
    sd00039
    Location:2361
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5231
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. NM_022372.6NP_071767.3  target of rapamycin complex subunit LST8 isoform a

    See identical proteins and their annotated locations for NP_071767.3

    Status: VALIDATED

    Source sequence(s)
    AC009065, BC001313
    Consensus CDS
    CCDS10462.2
    UniProtKB/Swiss-Prot
    Q9BVC4
    Related
    ENSP00000456405.1, ENST00000569417.6
    Conserved Domains (2) summary
    cd00200
    Location:14297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4783
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_147904.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009065
  2. NR_147905.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009065
  3. NR_147906.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009065
    Related
    ENST00000301724.14
  4. NR_147907.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009065, AK022227
    Related
    ENST00000566835.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2204628..2209453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450377.1XP_024306145.1  target of rapamycin complex subunit LST8 isoform X2

    Conserved Domains (2) summary
    cd00200
    Location:14303
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4789
    7WD40; WD40 repeat [structural motif]
  2. XM_024450378.1XP_024306146.1  target of rapamycin complex subunit LST8 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:2361
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5231
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_017023548.1XP_016879037.1  target of rapamycin complex subunit LST8 isoform X3

    UniProtKB/Swiss-Prot
    Q9BVC4
    Conserved Domains (2) summary
    sd00039
    Location:2361
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5231
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_005255479.2XP_005255536.1  target of rapamycin complex subunit LST8 isoform X2

    See identical proteins and their annotated locations for XP_005255536.1

    Conserved Domains (2) summary
    cd00200
    Location:14303
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4789
    7WD40; WD40 repeat [structural motif]
  5. XM_017023551.1XP_016879040.1  target of rapamycin complex subunit LST8 isoform X5

  6. XM_017023549.1XP_016879038.1  target of rapamycin complex subunit LST8 isoform X3

    UniProtKB/Swiss-Prot
    Q9BVC4
    Conserved Domains (2) summary
    sd00039
    Location:2361
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5231
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_017023552.1XP_016879041.1  target of rapamycin complex subunit LST8 isoform X6

  8. XM_017023550.1XP_016879039.1  target of rapamycin complex subunit LST8 isoform X4

  9. XM_005255475.3XP_005255532.2  target of rapamycin complex subunit LST8 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:17330
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:33322
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:66108
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_001751962.2 RNA Sequence

  2. XR_243294.4 RNA Sequence

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