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Mlst8 MTOR associated protein, LST8 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 56716, updated on 3-Feb-2019

Summary

Official Symbol
Mlst8provided by MGI
Official Full Name
MTOR associated protein, LST8 homolog (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1929514
See related
Ensembl:ENSMUSG00000024142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gbl; AA409454; AI505104; AI851821; 0610033N12Rik
Expression
Ubiquitous expression in thymus adult (RPKM 14.9), large intestine adult (RPKM 14.2) and 28 other tissues See more
Orthologs

Genomic context

See Mlst8 in Genome Data Viewer
Location:
17; 17 A3.3
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (24473550..24479114, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (24610496..24616023, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4833447I15 gene Neighboring gene phosphoglycolate phosphatase Neighboring gene BRICHOS domain containing 5 Neighboring gene CASK interacting protein 1 Neighboring gene TNF receptor-associated factor 7 Neighboring gene RAB26, member RAS oncogene family, opposite strand

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TORC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
TORC1 complex ISO
Inferred from Sequence Orthology
more info
PubMed 
TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TORC2 complex ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
target of rapamycin complex subunit LST8
Names
TORC subunit LST8
mammalian lethal with SEC13 protein 8
protein GbetaL
transducin (beta)-like 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252463.1NP_001239392.1  target of rapamycin complex subunit LST8 isoform 1

    See identical proteins and their annotated locations for NP_001239392.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the longer isoform (1).
    Source sequence(s)
    AC154237, AK002751, AK040100
    Consensus CDS
    CCDS28484.1
    UniProtKB/Swiss-Prot
    Q9DCJ1
    Related
    ENSMUSP00000157301.1, ENSMUST00000234335.1
    Conserved Domains (3) summary
    COG2319
    Location:10305
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:14297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4783
    7WD40; WD40 repeat [structural motif]
  2. NM_001252464.1NP_001239393.1  target of rapamycin complex subunit LST8 isoform 1

    See identical proteins and their annotated locations for NP_001239393.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the longer isoform (1).
    Source sequence(s)
    AC154237, AK040100, AK083731, CF750475
    Consensus CDS
    CCDS28484.1
    UniProtKB/Swiss-Prot
    Q9DCJ1
    Related
    ENSMUSP00000136287.1, ENSMUST00000179163.2
    Conserved Domains (3) summary
    COG2319
    Location:10305
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:14297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4783
    7WD40; WD40 repeat [structural motif]
  3. NM_001252465.1NP_001239394.1  target of rapamycin complex subunit LST8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two internal exons and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154237, AK040100, BM947104
    UniProtKB/Swiss-Prot
    Q9DCJ1
    Related
    ENSMUSP00000157225.1, ENSMUST00000234543.1
    Conserved Domains (3) summary
    COG2319
    Location:1257
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2361
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:5231
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_019988.5NP_064372.2  target of rapamycin complex subunit LST8 isoform 1

    See identical proteins and their annotated locations for NP_064372.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the longer isoform (1).
    Source sequence(s)
    AC154237, AK040100
    Consensus CDS
    CCDS28484.1
    UniProtKB/Swiss-Prot
    Q9DCJ1
    Related
    ENSMUSP00000065004.6, ENSMUST00000070888.13
    Conserved Domains (3) summary
    COG2319
    Location:10305
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:14297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4783
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    24473550..24479114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317587.1XP_017173076.1  target of rapamycin complex subunit LST8 isoform X1

  2. XM_006524679.3XP_006524742.1  target of rapamycin complex subunit LST8 isoform X3

    Conserved Domains (3) summary
    COG2319
    Location:10319
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:14296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4682
    7WD40; WD40 repeat [structural motif]
  3. XM_006524678.2XP_006524741.1  target of rapamycin complex subunit LST8 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:10321
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:14298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4682
    7WD40; WD40 repeat [structural motif]
  4. XM_017317586.1XP_017173075.1  target of rapamycin complex subunit LST8 isoform X1

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