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NCAPG non-SMC condensin I complex subunit G [ Homo sapiens (human) ]

Gene ID: 64151, updated on 17-Jun-2019

Summary

Official Symbol
NCAPGprovided by HGNC
Official Full Name
non-SMC condensin I complex subunit Gprovided by HGNC
Primary source
HGNC:HGNC:24304
See related
Ensembl:ENSG00000109805 MIM:606280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAPG; CHCG; YCG1; NY-MEL-3
Summary
This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression
Broad expression in bone marrow (RPKM 7.5), lymph node (RPKM 7.1) and 21 other tissues See more
Orthologs

Genomic context

See NCAPG in Genome Data Viewer
Location:
4p15.31
Exon count:
21
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (17810813..17844865)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (17812436..17846488)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 28 Neighboring gene family with sequence similarity 184 member B Neighboring gene DDB1 and CUL4 associated factor 16 Neighboring gene ligand dependent nuclear receptor corepressor like Neighboring gene keratin 18 pseudogene 63 Neighboring gene uncharacterized LOC107986220

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog

Pathways from BioSystems

  • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora B signaling, organism-specific biosystem
    Aurora B signaling
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Condensation of Prometaphase Chromosomes, organism-specific biosystem (from REACTOME)
    Condensation of Prometaphase Chromosomes, organism-specific biosystemThe condensin I complex is evolutionarily conserved and consists of five subunits: two SMC (structural maintenance of chromosomes) family subunits, SMC2 and SMC4, and three non-SMC subunits, NCAPD2, ...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12450, MGC126525

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic chromosome condensation IDA
Inferred from Direct Assay
more info
PubMed 
mitotic chromosome condensation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
condensed chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
condensed chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
condensin complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
condensin complex subunit 3
Names
XCAP-G homolog
chromosome condensation protein G
chromosome-associated protein G
condensin subunit CAP-G
melanoma antigen NY-MEL-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022346.5NP_071741.2  condensin complex subunit 3

    See identical proteins and their annotated locations for NP_071741.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AC005768, AF331796, BG398543, DB451361
    Consensus CDS
    CCDS3424.1
    UniProtKB/Swiss-Prot
    Q9BPX3
    Related
    ENSP00000251496.2, ENST00000251496.7
    Conserved Domains (3) summary
    pfam12719
    Location:559853
    Cnd3; Nuclear condensing complex subunits, C-term domain
    pfam13646
    Location:103204
    HEAT_2; HEAT repeats
    sd00044
    Location:208234
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_073124.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005768, BC143383, BG398543, DB451361

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    17810813..17844865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008543.2XP_016864032.1  condensin complex subunit 3 isoform X1

  2. XM_011513876.3XP_011512178.1  condensin complex subunit 3 isoform X3

    Conserved Domains (1) summary
    pfam12719
    Location:330624
    Cnd3; Nuclear condensing complex subunits, C-term domain
  3. XM_017008544.2XP_016864033.1  condensin complex subunit 3 isoform X2

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