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SELENOP selenoprotein P [ Homo sapiens (human) ]

Gene ID: 6414, updated on 27-Sep-2020

Summary

Official Symbol
SELENOPprovided by HGNC
Official Full Name
selenoprotein Pprovided by HGNC
Primary source
HGNC:HGNC:10751
See related
Ensembl:ENSG00000250722 MIM:601484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SeP; SELP; SEPP; SEPP1
Summary
This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018]
Expression
Broad expression in liver (RPKM 1192.8), small intestine (RPKM 1057.6) and 22 other tissues See more
Orthologs

Genomic context

See SELENOP in Genome Data Viewer
Location:
5p12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (42799880..42811892, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (42799982..42812024, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 35 pseudogene Neighboring gene growth hormone receptor Neighboring gene SERPINE1 mRNA binding protein 1 pseudogene 6 Neighboring gene GHR downstream promoter region module B Neighboring gene coiled-coil domain containing 152 Neighboring gene PRELI domain containing 3B pseudogene 4 Neighboring gene peptidylprolyl isomerase A pseudogene 77

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of selenoprotein P (SEPP1) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
selenium binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
brain development IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
platelet degranulation TAS
Traceable Author Statement
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress TAS
Traceable Author Statement
more info
 
selenium compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sexual reproduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
platelet dense granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
selenoprotein P
Names
selenoprotein P, plasma, 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085486.3NP_001078955.1  selenoprotein P isoform 1 precursor

    See identical proteins and their annotated locations for NP_001078955.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as Sepp1c) contains an additional 5' non-coding exon, and thus has a different and longer 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    HM005482
    Consensus CDS
    CCDS43311.1
    UniProtKB/Swiss-Prot
    P49908
    Related
    ENSP00000427671.1, ENST00000511224.5
    Conserved Domains (2) summary
    pfam04592
    Location:23243
    SelP_N; Selenoprotein P, N terminal region
    pfam04593
    Location:251381
    SelP_C; Selenoprotein P, C terminal region
  2. NM_001093726.3NP_001087195.1  selenoprotein P isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as Sepp1b) contains an additional 5' coding exon compared to variant 1. It initiates translation from an in-frame, upstream start codon, which results in an isoform (2) with a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL599162, BC040075, HM005482
    UniProtKB/Swiss-Prot
    P49908
    Conserved Domains (2) summary
    pfam04592
    Location:53273
    SelP_N; Selenoprotein P, N terminal region
    pfam04593
    Location:281411
    SelP_C; Selenoprotein P, C terminal region
  3. NM_005410.4NP_005401.3  selenoprotein P isoform 1 precursor

    See identical proteins and their annotated locations for NP_005401.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript and encodes isoform 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC040075, DA288385, HM005482
    Consensus CDS
    CCDS43311.1
    UniProtKB/Swiss-Prot
    P49908
    Related
    ENSP00000420939.1, ENST00000514985.6
    Conserved Domains (2) summary
    pfam04592
    Location:23243
    SelP_N; Selenoprotein P, N terminal region
    pfam04593
    Location:251381
    SelP_C; Selenoprotein P, C terminal region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    42799880..42811892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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