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Selenop selenoprotein P [ Mus musculus (house mouse) ]

Gene ID: 20363, updated on 26-Sep-2022

Summary

Official Symbol
Selenopprovided by MGI
Official Full Name
selenoprotein Pprovided by MGI
Primary source
MGI:MGI:894288
See related
Ensembl:ENSMUSG00000064373 AllianceGenome:MGI:894288
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Se-P; selp; Sepp1; D15Ucla1
Summary
This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in mouse), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants differing in 5' non-coding region have been described for this gene. Expression of these variants varies in different tissues and developmental stages (PMID:23064117). [provided by RefSeq, Feb 2017]
Expression
Broad expression in liver E18 (RPKM 1163.6), liver adult (RPKM 814.0) and 18 other tissues See more
Orthologs
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Genomic context

See Selenop in Genome Data Viewer
Location:
15 A1; 15 1.84 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (3300249..3309992)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (3270767..3280510)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene predicted gene, 30057 Neighboring gene coiled-coil domain containing 152 Neighboring gene predicted gene, 41254 Neighboring gene growth hormone receptor Neighboring gene Ghr downstream L1 promoter region

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables selenium binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables selenium binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
selenoprotein P
Names
plasma selenoprotein P
seP
selenoprotein P, plasma, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042613.2NP_001036078.1  selenoprotein P precursor

    See identical proteins and their annotated locations for NP_001036078.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as Sepp1b) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues. Variant Sepp1b is specifically localized to the hippocampus in the brain, and is a specific target for regulation by miR-7 microRNA (PMID:23064117).
    Source sequence(s)
    AA153204, AK002450, CK627189
    Consensus CDS
    CCDS27357.1
    UniProtKB/Swiss-Prot
    P70274, Q9Z2T7
    Related
    ENSMUSP00000081004.6, ENSMUST00000082424.12
    Conserved Domains (2) summary
    pfam04592
    Location:23241
    SelP_N; Selenoprotein P, N terminal region
    pfam04593
    Location:256380
    SelP_C; Selenoprotein P, C terminal region
  2. NM_001042614.2NP_001036079.1  selenoprotein P precursor

    See identical proteins and their annotated locations for NP_001036079.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as Sepp1c) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues.
    Source sequence(s)
    AA153204, AI892015, AK002450
    Consensus CDS
    CCDS27357.1
    UniProtKB/Swiss-Prot
    P70274, Q9Z2T7
    Conserved Domains (2) summary
    pfam04592
    Location:23241
    SelP_N; Selenoprotein P, N terminal region
    pfam04593
    Location:256380
    SelP_C; Selenoprotein P, C terminal region
  3. NM_009155.4NP_033181.3  selenoprotein P precursor

    See identical proteins and their annotated locations for NP_033181.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues.
    Source sequence(s)
    AA153204, AK002450, CB231357
    Consensus CDS
    CCDS27357.1
    UniProtKB/Swiss-Prot
    P70274, Q9Z2T7
    Related
    ENSMUSP00000124305.3, ENSMUST00000159216.10
    Conserved Domains (2) summary
    pfam04592
    Location:23241
    SelP_N; Selenoprotein P, N terminal region
    pfam04593
    Location:256380
    SelP_C; Selenoprotein P, C terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    3300249..3309992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)