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Sdf2l1 stromal cell-derived factor 2-like 1 [ Mus musculus (house mouse) ]

Gene ID: 64136, updated on 4-Feb-2026
Official Symbol
Sdf2l1provided by MGI
Official Full Name
stromal cell-derived factor 2-like 1provided by MGI
Primary source
MGI:MGI:2149842
See related
Ensembl:ENSMUSG00000022769 AllianceGenome:MGI:2149842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ATPase binding activity; misfolded protein binding activity; and protein-folding chaperone binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to act upstream of or within ERAD pathway; cellular response to misfolded protein; and regulation of apoptotic process. Part of endoplasmic reticulum chaperone complex. Is expressed in ventricular layer. Orthologous to human SDF2L1 (stromal cell derived factor 2 like 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in ovary adult (RPKM 56.1), colon adult (RPKM 48.1) and 28 other tissues See more
Orthologs
all
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See Sdf2l1 in Genome Data Viewer
Location:
16 A3; 16 10.62 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16948002..16950247, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17130138..17132383, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2610318N02 gene Neighboring gene STARR-positive B cell enhancer ABC_E9927 Neighboring gene microRNA 130b Neighboring gene microRNA 301b Neighboring gene STARR-positive B cell enhancer ABC_E7429 Neighboring gene STARR-positive B cell enhancer ABC_E214 Neighboring gene Rps20 pseudogene Neighboring gene coiled-coil domain containing 116 Neighboring gene STARR-positive B cell enhancer ABC_E4157 Neighboring gene YdjC homolog (bacterial)

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. Shirotani K, et al. J Biol Chem, 2001 Jun 15. PMID 11278416
  2. Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family. Fukuda S, et al. Biochem Biophys Res Commun, 2001 Jan 12. PMID 11162531
  3. Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism. Sasako T, et al. Nat Commun, 2019 Feb 27. PMID 30814508, Free PMC Article
  4. SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells. Tiwari A, et al. J Cell Sci, 2013 May 1. PMID 23444373
  5. Mice without macroH2A histone variants. Pehrson JR, et al. Mol Cell Biol, 2014 Dec. PMID 25312643, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding IEA
Inferred from Electronic Annotation
more info
  
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables misfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within ERAD pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within cellular response to misfolded protein ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein refolding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein refolding ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of endoplasmic reticulum chaperone complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of protein folding chaperone complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein folding chaperone complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
stromal cell-derived factor 2-like protein 1
Names
SDF2-like protein 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022324.3 → NP_071719.1  stromal cell-derived factor 2-like protein 1 precursor

    See identical proteins and their annotated locations for NP_071719.1

    Status: VALIDATED

    Source sequence(s)
    BC053425, BY253823
    Consensus CDS
    CCDS37270.1
    UniProtKB/Swiss-Prot
    Q9ESP1, Q9ESP2
    Related
    ENSMUSP00000023453.8, ENSMUST00000023453.10
    Conserved Domains (2) summary
    smart00472
    Location:95 → 150
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cl19745
    Location:159 → 201
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    16948002..16950247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESP1.2 GenPept UniProtKB/Swiss-Prot:Q9ESP1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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