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SDF2L1 stromal cell derived factor 2 like 1 [ Homo sapiens (human) ]

Gene ID: 23753, updated on 7-Jun-2020

Summary

Official Symbol
SDF2L1provided by HGNC
Official Full Name
stromal cell derived factor 2 like 1provided by HGNC
Primary source
HGNC:HGNC:10676
See related
Ensembl:ENSG00000128228 MIM:607551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in colon (RPKM 15.5), stomach (RPKM 14.1) and 25 other tissues See more
Orthologs

Genomic context

See SDF2L1 in Genome Data Viewer
Location:
22q11.21
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (21642302..21644299)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21996542..21998588)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene YdjC chitooligosaccharide deacetylase homolog Neighboring gene coiled-coil domain containing 116 Neighboring gene microRNA 301b Neighboring gene microRNA 130b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with stromal cell-derived factor 2-like 1 (SDF2L1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with SDF2L1 PubMed
env HIV-1 gp160 is identified to have a physical interaction with stromal cell-derived factor 2-like 1 (SDF2L1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IEA
Inferred from Electronic Annotation
more info
 
chaperone binding IEA
Inferred from Electronic Annotation
more info
 
dolichyl-phosphate-mannose-protein mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
misfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ER-associated misfolded protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum chaperone complex IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
stromal cell-derived factor 2-like protein 1
Names
PWP1-interacting protein 8
SDF2-like 1
SDF2-like protein 1
dihydropyrimidinase-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022044.3NP_071327.2  stromal cell-derived factor 2-like protein 1 precursor

    See identical proteins and their annotated locations for NP_071327.2

    Status: VALIDATED

    Source sequence(s)
    AY359118
    Consensus CDS
    CCDS13792.1
    UniProtKB/Swiss-Prot
    Q9HCN8
    Related
    ENSP00000248958.4, ENST00000248958.5
    Conserved Domains (1) summary
    cl25703
    Location:53200
    PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    21642302..21644299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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