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GOLPH3 golgi phosphoprotein 3 [ Homo sapiens (human) ]

Gene ID: 64083, updated on 24-Nov-2020

Summary

Official Symbol
GOLPH3provided by HGNC
Official Full Name
golgi phosphoprotein 3provided by HGNC
Primary source
HGNC:HGNC:15452
See related
Ensembl:ENSG00000113384 MIM:612207
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GOPP1; GPP34; MIDAS; Vps74
Summary
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in gall bladder (RPKM 38.1), prostate (RPKM 32.0) and 25 other tissues See more
Orthologs

Genomic context

See GOLPH3 in Genome Data Viewer
Location:
5p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (32124711..32174319, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (32124817..32174425, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 2 Neighboring gene microRNA 4279 Neighboring gene uncharacterized LOC105374711 Neighboring gene MTMR12 eExon liver enhancer Neighboring gene ribosomal protein L27 pseudogene 10 Neighboring gene myotubularin related protein 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of golgi phosphoprotein 3 (GOLPH3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with golgi phosphoprotein 3 (GOLPH3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90675

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol-4-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi ribbon formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi vesicle budding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi vesicle budding IMP
Inferred from Mutant Phenotype
more info
PubMed 
asymmetric Golgi ribbon formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion molecule production IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to rapamycin IMP
Inferred from Mutant Phenotype
more info
PubMed 
gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycoprotein biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein retention in Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrion organization IDA
Inferred from Direct Assay
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi cisterna IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi cisterna IDA
Inferred from Direct Assay
more info
PubMed 
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endosome IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Golgi phosphoprotein 3
Names
coat protein GPP34
coat-protein
golgi peripheral membrane protein 1, 34 kDa
golgi protein
golgi-associated protein
mitochondrial DNA absence factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022130.4NP_071413.1  Golgi phosphoprotein 3

    See identical proteins and their annotated locations for NP_071413.1

    Status: REVIEWED

    Source sequence(s)
    AC025178, AC025181
    Consensus CDS
    CCDS3896.1
    UniProtKB/Swiss-Prot
    Q9H4A6
    Related
    ENSP00000265070.6, ENST00000265070.7
    Conserved Domains (1) summary
    pfam05719
    Location:62278
    GPP34; Golgi phosphoprotein 3 (GPP34)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    32124711..32174319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009686.2XP_016865175.1  Golgi phosphoprotein 3 isoform X1

    Conserved Domains (1) summary
    pfam05719
    Location:2179
    GPP34; Golgi phosphoprotein 3 (GPP34)
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