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MYO1G myosin IG [ Homo sapiens (human) ]

Gene ID: 64005, updated on 18-Aug-2020

Summary

Official Symbol
MYO1Gprovided by HGNC
Official Full Name
myosin IGprovided by HGNC
Primary source
HGNC:HGNC:13880
See related
Ensembl:ENSG00000136286 MIM:600642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HA2; MHAG; HLA-HA2
Summary
MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]
Expression
Biased expression in bone marrow (RPKM 19.0), spleen (RPKM 14.5) and 9 other tissues See more
Orthologs

Genomic context

See MYO1G in Genome Data Viewer
Location:
7p13
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (44962662..44979105, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45002260..45018704, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375262 Neighboring gene mitochondrial ribosomal protein S23 pseudogene 1 Neighboring gene uncharacterized LOC102723334 Neighboring gene small nucleolar RNA host gene 15 Neighboring gene small nucleolar RNA, H/ACA box 9 Neighboring gene CCM2 scaffold protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of myosin IG (MYO1G) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142104

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-3,4-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell meandering migration IEA
Inferred from Electronic Annotation
more info
 
T cell mediated immunity ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell gliding IEA
Inferred from Electronic Annotation
more info
 
cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
vesicle transport along actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
filopodium IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
leading edge membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myosin complex IEA
Inferred from Electronic Annotation
more info
 
phagocytic cup ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-Ig
Names
minor histocompatibility antigen HA-2
myosin-Ig

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033054.3NP_149043.2  unconventional myosin-Ig

    See identical proteins and their annotated locations for NP_149043.2

    Status: VALIDATED

    Source sequence(s)
    AA651942, AC004847, BC117241
    Consensus CDS
    CCDS34629.1
    UniProtKB/Swiss-Prot
    B0I1T2
    Related
    ENSP00000258787.7, ENST00000258787.12
    Conserved Domains (3) summary
    smart00242
    Location:4706
    MYSc; Myosin. Large ATPases
    cd01378
    Location:23694
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:815980
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    44962662..44979105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012503.1XP_016867992.1  unconventional myosin-Ig isoform X1

  2. XM_017012504.2XP_016867993.1  unconventional myosin-Ig isoform X2

RNA

  1. XR_926943.2 RNA Sequence

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