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Myo1g myosin IG [ Mus musculus (house mouse) ]

Gene ID: 246177, updated on 28-Oct-2024

Summary

Official Symbol
Myo1gprovided by MGI
Official Full Name
myosin IGprovided by MGI
Primary source
MGI:MGI:1927091
See related
Ensembl:ENSMUSG00000020437 AllianceGenome:MGI:1927091
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E430002D17Rik
Summary
Enables phosphatidylinositol-3,4,5-trisphosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in Fc-gamma receptor signaling pathway involved in phagocytosis and T cell mediated immunity. Acts upstream of or within several processes, including T cell meandering migration; cell gliding; and phagocytosis. Located in several cellular components, including lamellipodium; microvillus; and phagocytic cup. Orthologous to human MYO1G (myosin IG). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in spleen adult (RPKM 76.0), thymus adult (RPKM 51.7) and 6 other tissues See more
Orthologs
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Genomic context

See Myo1g in Genome Data Viewer
Location:
11 A1; 11 4.3 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6456548..6470960, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6506548..6520960, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11469 Neighboring gene purine rich element binding protein B Neighboring gene STARR-positive B cell enhancer ABC_E2980 Neighboring gene STARR-seq mESC enhancer starr_28469 Neighboring gene small nucleolar RNA host gene 15 Neighboring gene small nucleolar RNA, H/ACA box 9 Neighboring gene predicted gene, 24000

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
PubMed 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in leading edge membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
unconventional myosin-Ig
Names
myosin 1G
myosin-Ig

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178440.4NP_848534.2  unconventional myosin-Ig

    See identical proteins and their annotated locations for NP_848534.2

    Status: VALIDATED

    Source sequence(s)
    AK030825, AK152797, AK171505
    Consensus CDS
    CCDS24421.1
    UniProtKB/Swiss-Prot
    Q5SUA5, Q8BIT8, Q8BJ17, Q8BJ65, Q8R019, Q91ZI1
    Related
    ENSMUSP00000003459.4, ENSMUST00000003459.4
    Conserved Domains (3) summary
    smart00242
    Location:10712
    MYSc; Myosin. Large ATPases
    cd01378
    Location:29700
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8211015
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    6456548..6470960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514702.1XP_006514765.1  unconventional myosin-Ig isoform X2

    Conserved Domains (2) summary
    cd01378
    Location:1606
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:727898
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  2. XM_006514700.1XP_006514763.1  unconventional myosin-Ig isoform X1

    Conserved Domains (2) summary
    cd01378
    Location:52715
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8361007
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RNA

  1. XR_380967.2 RNA Sequence