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CCL24 C-C motif chemokine ligand 24 [ Homo sapiens (human) ]

Gene ID: 6369, updated on 26-Oct-2022

Summary

Official Symbol
CCL24provided by HGNC
Official Full Name
C-C motif chemokine ligand 24provided by HGNC
Primary source
HGNC:HGNC:10623
See related
Ensembl:ENSG00000106178 MIM:602495; AllianceGenome:HGNC:10623
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ckb-6; MPIF2; MPIF-2; SCYA24
Summary
This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. This protein also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. Finally, the protein is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2020]
Expression
Biased expression in small intestine (RPKM 18.6), colon (RPKM 9.1) and 8 other tissues See more
Orthologs
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Genomic context

See CCL24 in Genome Data Viewer
Location:
7q11.23
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (75810825..75823372, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (77097889..77110477, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (75440143..75452690, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein 1 Neighboring gene Sharpr-MPRA regulatory region 13243 Neighboring gene Sharpr-MPRA regulatory region 12151 Neighboring gene C-C motif chemokine ligand 26 Neighboring gene THO complex 4 pseudogene Neighboring gene Sharpr-MPRA regulatory region 1050

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Treatment of human primary monocyte-derived macrophages with HIV-1 Nef upregulates expression and release of CCL24/eotaxin-2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables CCR3 chemokine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to interleukin-1 IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to tumor necrosis factor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in eosinophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in eosinophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lymphocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in monocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of eosinophil migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
C-C motif chemokine 24
Names
CK-beta-6
chemokine (C-C motif) ligand 24
eosinophil chemotactic protein 2
eotaxin-2
myeloid progenitor inhibitory factor 2
small inducible cytokine subfamily A (Cys-Cys), member 24
small-inducible cytokine A24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371193.1NP_001358122.1  C-C motif chemokine 24 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC005102, AK312216
    Consensus CDS
    CCDS34670.1
    UniProtKB/Swiss-Prot
    B2R5K2
    Related
    ENSP00000400533.1, ENST00000416943.1
    Conserved Domains (1) summary
    cd00272
    Location:3390
    Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...
  2. NM_002991.3NP_002982.2  C-C motif chemokine 24 precursor

    See identical proteins and their annotated locations for NP_002982.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC005102
    Consensus CDS
    CCDS34670.1
    UniProtKB/Swiss-Prot
    B2R5K2, O00175
    Related
    ENSP00000222902.2, ENST00000222902.7
    Conserved Domains (1) summary
    cd00272
    Location:3390
    Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    75810825..75823372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516460.3XP_011514762.1  C-C motif chemokine 24 isoform X1

    See identical proteins and their annotated locations for XP_011514762.1

    UniProtKB/Swiss-Prot
    B2R5K2, O00175
    Conserved Domains (1) summary
    cd00272
    Location:3390
    Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    77097889..77110477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)