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Ccl24 chemokine (C-C motif) ligand 24 [ Mus musculus (house mouse) ]

Gene ID: 56221, updated on 25-Jan-2022

Summary

Official Symbol
Ccl24provided by MGI
Official Full Name
chemokine (C-C motif) ligand 24provided by MGI
Primary source
MGI:MGI:1928953
See related
Ensembl:ENSMUSG00000004814 AllianceGenome:MGI:1928953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CKb-6; MPIF-2; Scya24
Summary
Enables cytokine activity. Involved in positive regulation of angiogenesis and positive regulation of inflammatory response. Acts upstream of or within chemotaxis and positive regulation of eosinophil migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in asthma and rhinitis. Orthologous to human CCL24 (C-C motif chemokine ligand 24). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in mammary gland adult (RPKM 5.0), liver E18 (RPKM 4.5) and 19 other tissues See more
Orthologs
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Genomic context

See Ccl24 in Genome Data Viewer
Location:
5; 5 G2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135598789..135601977, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135569935..135573123, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (136045807..136048913, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein 1 Neighboring gene predicted gene, 52790 Neighboring gene chemokine (C-C motif) ligand 26 Neighboring gene rhomboid domain containing 2 Neighboring gene predicted gene 15607 Neighboring gene predicted gene, 40345 Neighboring gene cytochrome p450 oxidoreductase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables CCR3 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to interferon-gamma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to interleukin-1 IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to tumor necrosis factor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in eosinophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in eosinophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lymphocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in monocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of eosinophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
C-C motif chemokine 24
Names
CC chemokine CCL24
eosinophil chemotactic protein 2
eotaxin-2
small-inducible cytokine A24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356630.1NP_001343559.1  C-C motif chemokine 24 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC083858, BC065389
    Consensus CDS
    CCDS19742.1
    Related
    ENSMUSP00000144002.2, ENSMUST00000201401.2
    Conserved Domains (1) summary
    cd00272
    Location:3390
    Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...
  2. NM_019577.5NP_062523.1  C-C motif chemokine 24 precursor

    See identical proteins and their annotated locations for NP_062523.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC083858, AK009718, BC065389, BX524006
    Consensus CDS
    CCDS19742.1
    UniProtKB/Swiss-Prot
    Q9JKC0
    UniProtKB/TrEMBL
    Q3U0A4
    Related
    ENSMUSP00000004936.7, ENSMUST00000004936.10
    Conserved Domains (1) summary
    cd00272
    Location:3390
    Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    135598789..135601977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504444.3XP_006504507.1  C-C motif chemokine 24 isoform X1

    See identical proteins and their annotated locations for XP_006504507.1

    UniProtKB/Swiss-Prot
    Q9JKC0
    UniProtKB/TrEMBL
    Q3U0A4
    Conserved Domains (1) summary
    cd00272
    Location:3390
    Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...
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