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BDKRB2 bradykinin receptor B2 [ Homo sapiens (human) ]

Gene ID: 624, updated on 8-Jul-2018
Official Symbol
BDKRB2provided by HGNC
Official Full Name
bradykinin receptor B2provided by HGNC
Primary source
HGNC:HGNC:1030
See related
Ensembl:ENSG00000168398 MIM:113503; Vega:OTTHUMG00000171408
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B2R; BK2; BK-2; BKR2; BRB2
Summary
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in urinary bladder (RPKM 13.5), gall bladder (RPKM 13.3) and 16 other tissues See more
Orthologs
See BDKRB2 in Genome Data Viewer
Location:
14q32.2
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (96204798..96244329)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96671016..96710666)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene TCL1 upstream neural differentiation-associated RNA Neighboring gene chromosome 14 open reading frame 132 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 1 Neighboring gene bradykinin receptor B1 Neighboring gene autophagy related 2B

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of bradykinin receptor B2 (BDKRB2) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: BDKRB1

Homology

Clone Names

  • DKFZp686O088

Gene Ontology Provided by GOA

Function Evidence Code Pubs
bradykinin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol phospholipase C activity TAS
Traceable Author Statement
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
type 1 angiotensin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
B2 bradykinin receptor
Names
BK-2 receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000623.3NP_000614.1  B2 bradykinin receptor

    See identical proteins and their annotated locations for NP_000614.1

    Status: REVIEWED

    Source sequence(s)
    AL355102, DA096163, DC422332
    Consensus CDS
    CCDS9942.1
    UniProtKB/Swiss-Prot
    P30411
    Related
    ENSP00000450482.1, OTTHUMP00000245971, ENST00000554311.1, OTTHUMT00000413294
    Conserved Domains (1) summary
    pfam00001
    Location:74332
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    96204798..96244329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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