BDKRB2 bradykinin receptor B2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BDKRB2provided by HGNC
Official Full Name: bradykinin receptor B2provided by HGNC
Primary source: HGNC:HGNC:1030
See related: Ensembl:ENSG00000168398 MIM:113503; AllianceGenome:HGNC:1030
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: B2R; BK2; BK-2; BKR2; BRB2
Summary: This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020]
Expression: Broad expression in urinary bladder (RPKM 13.5), gall bladder (RPKM 13.3) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q32.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (96204839..96244164)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (90436088..90475413)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (96671176..96710501)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Function and structure of bradykinin receptor 2 for drug discovery.
Title: Function and structure of bradykinin receptor 2 for drug discovery.
The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.
Title: The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.
Cryo-EM structures of human bradykinin receptor-Gq proteins complexes.
Title: Cryo-EM structures of human bradykinin receptor-G(q) proteins complexes.
ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors.
Title: ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors.
Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children.
Title: Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children.
Association of Variants Near the Bradykinin Receptor B2 Gene With Angioedema in Patients Taking ACE Inhibitors.
Title: Association of Variants Near the Bradykinin Receptor B(2) Gene With Angioedema in Patients Taking ACE Inhibitors.
Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene.
Title: Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene.
BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma.
Title: BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma.
Down-regulation of B2R contributes to preeclampsia by inhibiting human trophoblast cell invasion and angiogenesis.
Title: Down-regulation of B2R contributes to preeclampsia by inhibiting human trophoblast cell invasion and angiogenesis.
Bradykinin stimulates prostaglandin E2 release in human skeletal muscular fibroblasts.
Title: Bradykinin stimulates prostaglandin E(2) release in human skeletal muscular fibroblasts.

Submit: New GeneRIF Correction See all GeneRIFs (168)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat-induced upregulation of bradykinin receptor B2 (BDKRB2) in primary human brain microvascular endothelial cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC150944P1 (e-PCR)
- UniSTS:271125

NoName (e-PCR)
- UniSTS:482082

RH70880 (e-PCR)
- UniSTS:47187

NoName (e-PCR)
- UniSTS:481672

NoName (e-PCR)
- UniSTS:486806

Homology

Homologs of the BDKRB2 gene: The BDKRB2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 311 organisms have orthologs with human gene BDKRB2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables bradykinin receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables bradykinin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol phospholipase C activity	TAS Traceable Author Statement more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables type 1 angiotensin receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in arachidonic acid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in blood circulation	NAS Non-traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	IC Inferred by Curator more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	TAS Traceable Author Statement more info	PubMed
involved_in regulation of vascular permeability	IC Inferred by Curator more info	PubMed
involved_in regulation of vasoconstriction	IC Inferred by Curator more info	PubMed
involved_in response to salt stress	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle contraction	IC Inferred by Curator more info	PubMed
involved_in transmembrane receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: B2 bradykinin receptor

Names: BK-2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000623.4 → NP_000614.1 B2 bradykinin receptor

See identical proteins and their annotated locations for NP_000614.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AL355102

Consensus CDS

CCDS9942.1

UniProtKB/Swiss-Prot

P30411

Conserved Domains (1) summary

cd15381
Location:58 → 343

7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001379692.1 → NP_001366621.1 B2 bradykinin receptor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AL355102

Consensus CDS

CCDS9942.1

UniProtKB/Swiss-Prot

P30411

Related

ENSP00000450482.1, ENST00000554311.2

Conserved Domains (1) summary

cd15381
Location:58 → 343

7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors