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BDKRB1 bradykinin receptor B1 [ Homo sapiens (human) ]

Gene ID: 623, updated on 1-Jul-2018
Official Symbol
BDKRB1provided by HGNC
Official Full Name
bradykinin receptor B1provided by HGNC
Primary source
HGNC:HGNC:1029
See related
Ensembl:ENSG00000100739 MIM:600337; Vega:OTTHUMG00000171412
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B1R; BKR1; B1BKR; BKB1R; BDKRB2; BRADYB1
Summary
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Biased expression in gall bladder (RPKM 7.4), urinary bladder (RPKM 5.2) and 12 other tissues See more
Orthologs
See BDKRB1 in Genome Data Viewer
Location:
14q32.2
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (96256210..96264763)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96721641..96735304)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene chromosome 14 open reading frame 132 Neighboring gene bradykinin receptor B2 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 1 Neighboring gene autophagy related 2B Neighboring gene GSK3B interacting protein Neighboring gene RNA, U2 small nuclear 33, pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: BDKRB2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
bradykinin receptor activity IEA
Inferred from Electronic Annotation
more info
 
peptide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cell migration IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
protein kinase C-activating G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
B1 bradykinin receptor
Names
BK-1 receptor
bradykinin B1 receptor
bradykinin receptor 1
bradykinin receptor B2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000710.3NP_000701.2  B1 bradykinin receptor

    See identical proteins and their annotated locations for NP_000701.2

    Status: REVIEWED

    Source sequence(s)
    AJ238044, AL355102, CB130642
    Consensus CDS
    CCDS9943.1
    UniProtKB/Swiss-Prot
    P46663
    Related
    ENSP00000216629.6, OTTHUMP00000245974, ENST00000216629.10, OTTHUMT00000413300
    Conserved Domains (1) summary
    cd15380
    Location:38323
    7tmA_BK-1; bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    96256210..96264763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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