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BDKRB1 bradykinin receptor B1 [ Homo sapiens (human) ]

Gene ID: 623, updated on 19-Jul-2021

Summary

Official Symbol
BDKRB1provided by HGNC
Official Full Name
bradykinin receptor B1provided by HGNC
Primary source
HGNC:HGNC:1029
See related
Ensembl:ENSG00000100739 MIM:600337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B1R; BKR1; B1BKR; BKB1R; BRADYB1
Summary
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. [provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Biased expression in gall bladder (RPKM 7.4), urinary bladder (RPKM 5.2) and 12 other tissues See more
Orthologs
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Genomic context

See BDKRB1 in Genome Data Viewer
Location:
14q32.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (96256210..96264763)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96722547..96731100)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene chromosome 14 open reading frame 132 Neighboring gene bradykinin receptor B2 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 1 Neighboring gene autophagy related 2B Neighboring gene Sharpr-MPRA regulatory region 11883 Neighboring gene GSK3B interacting protein Neighboring gene RNA, U2 small nuclear 33, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: BDKRB2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables bradykinin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
B1 bradykinin receptor
Names
BK-1 receptor
bradykinin B1 receptor
bradykinin receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000710.4NP_000701.2  B1 bradykinin receptor

    See identical proteins and their annotated locations for NP_000701.2

    Status: REVIEWED

    Source sequence(s)
    AJ238044, AL355102, CB130642
    Consensus CDS
    CCDS9943.1
    UniProtKB/Swiss-Prot
    P46663
    Related
    ENSP00000216629.6, ENST00000216629.11
    Conserved Domains (1) summary
    cd15380
    Location:38323
    7tmA_BK-1; bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001386007.1NP_001372936.1  B1 bradykinin receptor

    Status: REVIEWED

    Source sequence(s)
    AL355102
    Related
    ENSP00000479276.1, ENST00000611804.1
    Conserved Domains (1) summary
    cd15380
    Location:38323
    7tmA_BK-1; bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    96256210..96264763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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