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Bdkrb1 bradykinin receptor, beta 1 [ Mus musculus (house mouse) ]

Gene ID: 12061, updated on 12-May-2024

Summary

Official Symbol
Bdkrb1provided by MGI
Official Full Name
bradykinin receptor, beta 1provided by MGI
Primary source
MGI:MGI:88144
See related
Ensembl:ENSMUSG00000041347 AllianceGenome:MGI:88144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B1R; BKR1; B1BKR; Bdkrb; BRADYB1
Summary
Enables peptide binding activity. Acts upstream of or within response to lipopolysaccharide. Predicted to be located in membrane and neuron projection. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in end stage renal disease; hypertension; and pulmonary fibrosis. Orthologous to human BDKRB1 (bradykinin receptor B1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
12 E; 12 55.81 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (105570350..105571770)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (105604091..105605511)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AU015791 Neighboring gene predicted gene, 40565 Neighboring gene STARR-seq mESC enhancer starr_33182 Neighboring gene bradykinin receptor, beta 2 Neighboring gene STARR-positive B cell enhancer ABC_E4041 Neighboring gene autophagy related 2B Neighboring gene STARR-seq mESC enhancer starr_33186 Neighboring gene STARR-seq mESC enhancer starr_33187 Neighboring gene STARR-positive B cell enhancer ABC_E5352 Neighboring gene GSK3B interacting protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables bradykinin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables bradykinin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
B1 bradykinin receptor
Names
BK-1 receptor
kinin B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007539.3NP_031565.1  B1 bradykinin receptor

    See identical proteins and their annotated locations for NP_031565.1

    Status: VALIDATED

    Source sequence(s)
    AC068459
    Consensus CDS
    CCDS26155.1
    UniProtKB/Swiss-Prot
    Q61125, Q9Z1F4
    UniProtKB/TrEMBL
    Q0VBD7, S4R1G8
    Related
    ENSMUSP00000045335.5, ENSMUST00000041229.5
    Conserved Domains (1) summary
    pfam00001
    Location:77319
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    105570350..105571770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)