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RPS15 ribosomal protein S15 [ Homo sapiens (human) ]

Gene ID: 6209, updated on 3-Nov-2024

Summary

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Official Symbol
RPS15provided by HGNC
Official Full Name
ribosomal protein S15provided by HGNC
Primary source
HGNC:HGNC:10388
See related
Ensembl:ENSG00000115268 MIM:180535; AllianceGenome:HGNC:10388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIG; S15; uS19
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in ovary (RPKM 257.5), spleen (RPKM 201.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See RPS15 in Genome Data Viewer
Location:
19p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1438396..1440495)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1408393..1410492)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1438395..1440494)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9708 Neighboring gene guanidinoacetate N-methyltransferase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9710 Neighboring gene DAZ associated protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1415933-1416526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1416527-1417121 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1423502-1424380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1424381-1425259 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1434260-1434763 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1438140-1439010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1440750-1441618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9713 Neighboring gene Sharpr-MPRA regulatory region 2129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1452009-1452642 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1452643-1453274 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1453275-1453907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1453908-1454539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1456369-1456885 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9720 Neighboring gene chromosome 19 open reading frame 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1478399-1478899 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1482223-1482834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9723 Neighboring gene proprotein convertase subtilisin/kexin type 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RPS15 mutations rewire RNA translation in chronic lymphocytic leukemia. Ntoufa S, et al. Blood Adv, 2021 Jul 13. PMID 34251413, Free PMC Article
  2. Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes. Shiga K, et al. Proc Natl Acad Sci U S A, 1990 May. PMID 2159154, Free PMC Article
  3. The functional role of the C-terminal tail of the human ribosomal protein uS19. Bulygin K, et al. Biochim Biophys Acta Gene Regul Mech, 2020 Mar. PMID 31991215
  4. mRNA regions where 80S ribosomes pause during translation elongation in vivo interact with protein uS19, a component of the decoding site. Babaylova ES, et al. Nucleic Acids Res, 2020 Jan 24. PMID 31802126, Free PMC Article
  5. Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia. Bretones G, et al. Blood, 2018 Nov 29. PMID 30181176, Free PMC Article

See all (190) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The value of RPS15 and MRPS27 in ischemic stroke.
    Title: The value of RPS15 and MRPS27 in ischemic stroke.
  2. RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m[6]A modification.
    Title: RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m(6)A modification.
  3. The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation.
    Title: The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation.
  4. RPS15 mutations rewire RNA translation in chronic lymphocytic leukemia.
    Title: RPS15 mutations rewire RNA translation in chronic lymphocytic leukemia.
  5. Findings suggest that the C-terminal tail of uS19 plays a key role in the accommodation of aa-tRNA at the A site.
    Title: The functional role of the C-terminal tail of the human ribosomal protein uS19.
  6. our findings demonstrate that the human ribosomal protein uS19 interacts with mRNAs during translation elongation and highlight the regions of mRNAs where ribosome pausing occurs, bringing new structural and functional insights into eukaryotic translation in vivo.
    Title: mRNA regions where 80S ribosomes pause during translation elongation in vivo interact with protein uS19, a component of the decoding site.
  7. Quantitative mass spectrometry analyses suggest that RPS15 variants may induce additional alterations in the translational machinery, as well as a metabolic shift at the proteome level in HEK293T and MEC-1 cells. These results indicate that chronic lymphocytic leukemia-related RPS15 mutations might act following patterns known for other ribosomal diseases.
    Title: Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia.
  8. we provide novel insights into the heterogeneous genomic landscape of relapsing chronic lymphocytic leukemia and report recurrent mutations in a "hotspot" region of RPS15
    Title: Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations.
  9. Study shows that ribosomal protein s15 is a key pathogenic LRRK2 substrate in Drosophila and human neuron Parkinson's disease models.
    Title: Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.
  10. RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network but employ different mechanisms to do so.
    Title: Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC111130

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables MDM2/MDM4 family protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin ligase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast differentiation HDA PubMed 
involved_in positive regulation of signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal small subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit HDA PubMed 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS19
Names
40S ribosomal protein S15
homolog of rat insulinoma
insulinoma protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017014.1 RefSeqGene

    Range
    5033..7132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018.5 → NP_001009.1  small ribosomal subunit protein uS19 isoform 2

    See identical proteins and their annotated locations for NP_001009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5' UTR and use of an alternate start codon compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC027307
    Consensus CDS
    CCDS12067.1
    UniProtKB/Swiss-Prot
    A5D8V9, P11174, P62841, Q3KRA1, Q9UDC2
    UniProtKB/TrEMBL
    K7EQJ5
    Related
    ENSP00000467466.3, ENST00000592588.7
    Conserved Domains (1) summary
    PTZ00096
    Location:1 → 143
    PTZ00096; 40S ribosomal protein S15; Provisional

  2. NM_001308226.2 → NP_001295155.1  small ribosomal subunit protein uS19 isoform 1

    See identical proteins and their annotated locations for NP_001295155.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC027307
    Consensus CDS
    CCDS77210.1
    UniProtKB/TrEMBL
    K7ELC2, K7EQJ5
    Related
    ENSP00000466010.1, ENST00000593052.5
    Conserved Domains (1) summary
    PTZ00096
    Location:12 → 150
    PTZ00096; 40S ribosomal protein S15; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    1438396..1440495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    1408393..1410492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62841.2 GenPept UniProtKB/Swiss-Prot:P62841

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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