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RPS15 ribosomal protein S15 [ Homo sapiens (human) ]

Gene ID: 6209, updated on 12-Oct-2019

Summary

Official Symbol
RPS15provided by HGNC
Official Full Name
ribosomal protein S15provided by HGNC
Primary source
HGNC:HGNC:10388
See related
Ensembl:ENSG00000115268 MIM:180535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIG; S15
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in ovary (RPKM 257.5), spleen (RPKM 201.4) and 25 other tissues See more
Orthologs

Genomic context

See RPS15 in Genome Data Viewer
Location:
19p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (1438364..1440497)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1438363..1440494)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene guanidinoacetate N-methyltransferase Neighboring gene DAZ associated protein 1 Neighboring gene Sharpr-MPRA regulatory region 2129 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene chromosome 19 open reading frame 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111130

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
osteoblast differentiation HDA PubMed 
rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal small subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation IC
Inferred by Curator
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit HDA PubMed 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
membrane HDA PubMed 
nucleoplasm NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
40S ribosomal protein S15
Names
homolog of rat insulinoma
insulinoma protein
small ribosomal subunit protein uS19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017014.1 RefSeqGene

    Range
    5001..7134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018.4NP_001009.1  40S ribosomal protein S15 isoform 2

    See identical proteins and their annotated locations for NP_001009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5' UTR and use of an alternate start codon compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BG253776, BU602036, J02984
    Consensus CDS
    CCDS12067.1
    UniProtKB/Swiss-Prot
    P62841
    Related
    ENSP00000467466.3, ENST00000592588.6
    Conserved Domains (1) summary
    PTZ00096
    Location:1143
    PTZ00096; 40S ribosomal protein S15; Provisional
  2. NM_001308226.1NP_001295155.1  40S ribosomal protein S15 isoform 1

    See identical proteins and their annotated locations for NP_001295155.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BE798984, BG253776, BG705752, BM558707
    Consensus CDS
    CCDS77210.1
    UniProtKB/TrEMBL
    K7ELC2
    Related
    ENSP00000466010.1, ENST00000593052.5
    Conserved Domains (1) summary
    PTZ00096
    Location:12150
    PTZ00096; 40S ribosomal protein S15; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    1438364..1440497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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