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Rps15 ribosomal protein S15 [ Mus musculus (house mouse) ]

Gene ID: 20054, updated on 5-Feb-2023

Summary

Official Symbol
Rps15provided by MGI
Official Full Name
ribosomal protein S15provided by MGI
Primary source
MGI:MGI:98117
See related
Ensembl:ENSMUSG00000063457 AllianceGenome:MGI:98117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
rig
Summary
Predicted to enable MDM2/MDM4 family protein binding activity and ubiquitin ligase inhibitor activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in positive regulation of signal transduction by p53 class mediator and ribosome biogenesis. Predicted to be located in cytosolic ribosome and nucleoplasm. Predicted to be part of cytosolic small ribosomal subunit. Orthologous to human RPS15 (ribosomal protein S15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 713.3), liver E14 (RPKM 562.9) and 28 other tissues See more
Orthologs
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Genomic context

See Rps15 in Genome Data Viewer
Location:
10; 10 C1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80128265..80129948)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80292431..80294114)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene guanidinoacetate methyltransferase Neighboring gene DAZ associated protein 1 Neighboring gene microRNA 6911 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene RIKEN cDNA 2310011J03 gene Neighboring gene proprotein convertase subtilisin/kexin type 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MDM2/MDM4 family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin ligase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ribosomal small subunit assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal small subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
 
part_of small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310726.1NP_001297655.1  40S ribosomal protein S15 isoform 2

    See identical proteins and their annotated locations for NP_001297655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC140229
    Consensus CDS
    CCDS78858.1
    UniProtKB/TrEMBL
    D3YTQ9
    Related
    ENSMUSP00000100997.2, ENSMUST00000062674.7
    Conserved Domains (1) summary
    cl00350
    Location:1116
    Ribosomal_S19; Ribosomal protein S19
  2. NM_009091.2NP_033117.1  40S ribosomal protein S15 isoform 1

    See identical proteins and their annotated locations for NP_033117.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA027738, AV569793
    Consensus CDS
    CCDS35978.1
    UniProtKB/Swiss-Prot
    P62843, Q52KC9
    UniProtKB/TrEMBL
    A0A6P5QJN7, A0A8C6GLM9
    Related
    ENSMUSP00000069004.8, ENSMUST00000068408.14
    Conserved Domains (1) summary
    PTZ00096
    Location:1143
    PTZ00096; 40S ribosomal protein S15; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80128265..80129948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)