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RPS9 ribosomal protein S9 [ Homo sapiens (human) ]

Gene ID: 6203, updated on 5-Jul-2020

Summary

Official Symbol
RPS9provided by HGNC
Official Full Name
ribosomal protein S9provided by HGNC
Primary source
HGNC:HGNC:10442
See related
Ensembl:ENSG00000170889 MIM:603631
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S9
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 603.9), bone marrow (RPKM 379.2) and 25 other tissues See more
Orthologs

Genomic context

See RPS9 in Genome Data Viewer
Location:
19q13.42
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (54200557..54207647)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54704608..54711515)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268246 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene tRNA splicing endonuclease subunit 34 Neighboring gene leukocyte immunoglobulin like receptor B3 Neighboring gene LSM14A, SCD6 homolog A (S. cerevisiae) pseudogene Neighboring gene uncharacterized LOC107985279

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S9 (RPS9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S9 (RPS9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S9 (RPS9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S9 (RPS9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translational fidelity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
 
translation IC
Inferred by Curator
more info
PubMed 
translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit HDA PubMed 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
ribosome NAS
Non-traceable Author Statement
more info
PubMed 
small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
40S ribosomal protein S9
Names
small ribosomal subunit protein uS4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013.4NP_001004.2  40S ribosomal protein S9 isoform a

    See identical proteins and their annotated locations for NP_001004.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 2, 3, and 4, encodes isoform a.
    Source sequence(s)
    AB055775, BC007410, U14971
    Consensus CDS
    CCDS12884.1
    UniProtKB/Swiss-Prot
    P46781
    UniProtKB/TrEMBL
    A0A024R4M0
    Related
    ENSP00000302896.4, ENST00000302907.9
    Conserved Domains (1) summary
    PTZ00155
    Location:11177
    PTZ00155; 40S ribosomal protein S9; Provisional
  2. NM_001321701.2NP_001308630.1  40S ribosomal protein S9 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1, 3, and 4, encodes isoform a.
    Source sequence(s)
    BC050660, CD389050
    Consensus CDS
    CCDS12884.1
    UniProtKB/Swiss-Prot
    P46781
    UniProtKB/TrEMBL
    A0A024R4M0
    Conserved Domains (1) summary
    PTZ00155
    Location:11177
    PTZ00155; 40S ribosomal protein S9; Provisional
  3. NM_001321702.2NP_001308631.1  40S ribosomal protein S9 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 2, and 4, encodes isoform a.
    Source sequence(s)
    AC245052, BC050660, BM313608, CD389050
    Consensus CDS
    CCDS12884.1
    UniProtKB/Swiss-Prot
    P46781
    UniProtKB/TrEMBL
    A0A024R4M0
    Related
    ENSP00000375632.1, ENST00000391752.5
    Conserved Domains (1) summary
    PTZ00155
    Location:11177
    PTZ00155; 40S ribosomal protein S9; Provisional
  4. NM_001321704.2NP_001308633.1  40S ribosomal protein S9 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1, 2, and 3, encodes isoform a.
    Source sequence(s)
    BC050660, BQ069656, CD389050
    Consensus CDS
    CCDS12884.1
    UniProtKB/Swiss-Prot
    P46781
    UniProtKB/TrEMBL
    A0A024R4M0
    Conserved Domains (1) summary
    PTZ00155
    Location:11177
    PTZ00155; 40S ribosomal protein S9; Provisional
  5. NM_001321705.2NP_001308634.1  40S ribosomal protein S9 isoform b

    Status: REVIEWED

    Source sequence(s)
    AW163829, BC050660, CD389050
    Conserved Domains (1) summary
    PTZ00155
    Location:11136
    PTZ00155; 40S ribosomal protein S9; Provisional
  6. NM_001321706.2NP_001308635.1  40S ribosomal protein S9 isoform c

    Status: REVIEWED

    Source sequence(s)
    BC050660, CD389050
    Consensus CDS
    CCDS82397.1
    UniProtKB/TrEMBL
    A8MXK4
    Related
    ENSP00000375631.3, ENST00000391751.7
    Conserved Domains (1) summary
    PTZ00155
    Location:1176
    PTZ00155; 40S ribosomal protein S9; Provisional

RNA

  1. NR_135762.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BC050660, BG911482, CD389050
    Related
    ENST00000436445.5
  2. NR_135763.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BC050660, BG753945, CD389050

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    54200557..54207647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027112.1XP_016882601.1  40S ribosomal protein S9 isoform X1

    UniProtKB/TrEMBL
    A8MXK4
    Conserved Domains (1) summary
    PTZ00155
    Location:1176
    PTZ00155; 40S ribosomal protein S9; Provisional

RNA

  1. XR_430207.2 RNA Sequence

  2. XR_002958341.1 RNA Sequence

    Related
    ENST00000495002.5
  3. XR_001753734.1 RNA Sequence

    Related
    ENST00000445961.5

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    175657..182446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NW_003571056.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NW_003571057.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NW_003571058.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NW_003571059.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    175830..182618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p13 ALT_REF_LOCI_8

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p13 ALT_REF_LOCI_9

    Range
    175840..182629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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